In vivo proton magnetic resonance spectroscopy of intraventricular tumours of the brain

Abstract

The aim of this study was to assess the usefulness of proton MR spectroscopy in the diagnosis of intraventricular tumours. Fifty-two intraventricular tumours pertaining to 16 different tumour types were derived from our database. All cases had single-voxel proton MR spectroscopy performed at TE at both 30 and 136 ms at 1.5 T. The Mann-Whitney U test was used to search for the most discriminative datapoints each tumour type. Characteristic trends were found for some groups: high Glx and Ala in meningiomas (p < 0.001 and p < 0.01, respectively), high mobile lipids in metastasis (p < 0.001), high Cho in PNET (p < 0.001), high mI + Gly in ependymoma (p < 0.001), high NAC (p < 0.01) in the absence of the normal brain parenchyma pattern in colloid cysts, and high mI/Gly and Ala in central neurocytoma. Proton MR spectroscopy provides additional metabolic information that could be useful in the diagnosis of intraventricular brain tumors.

In vivo MRS study of intraventricular tumors

“…The presence of Gly in CNCs was more consistently observed in the present study, including other CNCs studies from Kim et al (11), Yeh et al (15), Krishnamurthy et al (12), and Majos et al (3). High Cho/Cr surpassing gliomas seems to be the most consistent feature of neurocytomas across all the reports.…”

Proton Magnetic Resonance Spectroscopy of the Central Nervous System

“…Rijpkema et al found significantly increased Glx levels for oligodendrogliomas when compared to that of astrocytomas [97] using short TE 1 H-MRS. Additionally, in a study by Majos et al, ependymomas differentiated well from the other glial tumors by showing prominent peaks of mI+Gly and Taurine at long TE spectra [98].…”

The Outline of Prognosis and New Advances in Diagnosis of Oral Squamous Cell Carcinoma (OSCC): Review of the Literature

“…MR spectroscopy analyzes molecules such as hydrogen ions or protons. Proton spectroscopy is more commonly used [91,92]. There are several different metabolites, or products of metabolism, that can be measured to differentiate between tumour types.…”

“…Human brain contains hundreds of metabolites, but the proton MRS can only detect a few of them as the least millimolar concentrations are necessary for the metabolites to be detected. The major brain metabolites detected are choline (Cho), creatine (Cr), N-acetyl aspartate (NAA), lactate, myoinositol, glutamine and glutamate, lipids, and the amino acids leucine and alanine [91]. The frequency of these metabolites is measured in units called parts per million (ppm) and plotted on a graph as peaks of varying heights.…”