In vivo pharmacodynamic and pharmacokinetic interactions of<i>Hibiscus sabdariffa</i>calyces extracts with simvastatin

Showande, Segun Johnson; Adegbolagun, Olayemi Modupe; Igbinoba, Sharon Iyobor; Fakeye, Titilayo O.

doi:10.1111/jcpt.12629

Cited by 18 publications

(11 citation statements)

References 29 publications

(48 reference statements)

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“…Anthocyanin and quercetin were the components in Hibiscus sabdariffa extract responsible for the antihypertensive effect [2, 5, 9, 10]. However, several studies have found that coadministration of Hibiscus sabdariffa extract with conventional drugs such as acetaminophen, chloroquine, hydrochlorothiazide, simvastatin, and ciprofloxacin produces interactions and influences the efficacy of the primary drug [2, 11–14]…”

Section: Introductionmentioning

confidence: 99%

Effects of Hibiscus Sabdariffa Calyces Aqueous Extract on the Antihypertensive Potency of Captopril in the Two-Kidney-One-Clip Rat Hypertension Model

Nurfaradilla

Saputri

Harahap

2019

Evidence-Based Complementary and Alternative Medicine

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Hibiscus sabdariffa aqueous extract (HS) is often used as complementary therapy for hypertension. However, some studies have shown that coadministration with a conventional antihypertensive drug can affect drug potency. We compared the effects of HS plus captopril (CAP) coadministration to HS and CAP administration alone on blood pressure and renin-angiotensin-aldosterone system (RAAS) biomarkers in the rat two-kidney-one-clip (2K1C) model of hypertension. Male Sprague Dawley rats were randomly divided into seven groups (n=6/group), a normal control (SHAM) group, and six 2K1C groups. In 2K1C animals, hypertension was induced using a stainless microclip (inner diameter of 0.20 mm). Four weeks after 2K1C surgery, blood pressure was significantly higher than in the SHAM group. Then, model rats were randomly divided into negative control (2K1C, no treatment), positive control (4.5 mg captopril/200 g body weight [BW] orally [p.o.]), HS alone (30 mg/200 g BW; p.o.), and 3 co-treatment groups receiving HS (15, 30, or 60 mg/200 g BW; p.o.) plus 4.5 mg/200 g BW captopril. The treatments were performed for two weeks. Blood pressure was significantly reduced by all the drug treatments to near the level of SHAM controls. Plasma renin level, serum angiotensin converting enzyme (ACE) activity, and plasma angiotensin II level were also significantly elevated in the 2K1C group compared to the SHAM group. Both serum ACE activity and plasma angiotensin II level were significantly reduced to near SHAM group levels by all the drug treatments. Hibiscus sabdariffa aqueous extract alone can reduce blood pressure. This extract appears could be used as a supplement with captopril but may not provide any additional benefit.

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Section: Introductionmentioning

confidence: 99%

Effects of Hibiscus Sabdariffa Calyces Aqueous Extract on the Antihypertensive Potency of Captopril in the Two-Kidney-One-Clip Rat Hypertension Model

Nurfaradilla

Saputri

Harahap

2019

Evidence-Based Complementary and Alternative Medicine

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“…Another security risk is herb – drug interactions. Showande et al (Showande, Adegbolagun, Igbinoba, & Fakeye, ) showed that H. sabdariffa beverage and simvastatin coadministration might reduce the absorption, peak plasma concentration, and clearance of simvastatin; additionally, other studies have reported the adverse reactions of H. sabdariffa combined with hydrochlorothiazide and acetaminophen (Hopkins et al, ). Thus, H. sabdariffa safety warrants further investigation.…”

Section: Discussionmentioning

confidence: 99%

Effect of Hibiscus sabdariffa (Roselle) supplementation in regulating blood lipids among patients with metabolic syndrome and related disorders: A systematic review and meta‐analysis

Zhang

Yue

Wang³

et al. 2019

Phytotherapy Research

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This study aimed to assess the efficacy of Hibiscus sabdariffa (Roselle) in regulating blood lipids among patients with metabolic syndrome and related disorders. PubMed, the Cochrane Library, Embase, Web of Science, and Clinical Trials were searched to identify the randomised controlled trials meeting the inclusion criteria. Study selection, data extraction, and risk assessment were performed according to Cochrane handbook; available data were analysed using STATA 15.0 software. Eventually, nine trials involving 503 participants were included in this meta-analysis. The results showed that compared with the control group, H. sabdariffa supplementation could reduce total cholesterol (WMD = −14.66; 95% CI [−18.22, −11.10]; p = .000; I 2 = 46.9%) and low-density lipoprotein cholesterol (WMD = −9.46; 95% CI [−14.93, −3.99]; p = .001; I 2 = 50.1%) but could not effectively reduce triglyceride (WMD = −0.77; 95% CI [−7.87, 6.33]; p = 0.832; I 2 = 0%). Meanwhile, there were no serious adverse reactions reported in the included studies. To summarise, current evidence suggests that the benefits of H. sabdariffa supplementation to patients with metabolic diseases are associated with its cholesterol-lowering effects; however, more high-quality clinical trials are needed to confirm these results. K E Y W O R D Sblood lipids, dyslipidemia, Hibiscus sabdariffa, meta-analysis, metabolic syndrome

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“…Previous herb-drug pharmacokinetic interaction studies on Hibiscus sabdariffa aqueous extract showed similar observation. Coadministration of the extract could increase the clearance of acetaminophen, reduce the AUC and Cmax of chloroquine, and increase the clearance as well as reduce the AUC of simvastatin [4,7,8]. However, the coadministration of Hibiscus sabdariffa aqueous extract with captopril does not influence the antihypertensive potency of captopril or its effects on biomarkers of the renin-angiotensin-aldosterone system (RAAS).…”

Section: Effect Of Coadministration Of H Sabdariffa L Aqueousmentioning

confidence: 99%

“…Hibiscus sabdariffa L. (Malvaceae) is an herbaceous shrub grown in tropical areas such as India, Malaysia, Africa, Australia, Florida, the Philippines, and Indonesia [1]. Beverages made from H. sabdariffa L. (variously referred to as "sour tea" or "hibiscus tea") are consumed in many regions of the world and extracts have been used as traditional medicines in numerous cultures [2][3][4]. e consumption of hibiscus tea is growing in popularity owing to accumulating evidence that it can safely reduce blood pressure and serum cholesterol, two major risk factors for cardiovascular disease [3].…”

Section: Introductionmentioning

confidence: 99%

“…e consumption of hibiscus tea is growing in popularity owing to accumulating evidence that it can safely reduce blood pressure and serum cholesterol, two major risk factors for cardiovascular disease [3]. Furthermore, benefits against cancer, excess weight, liver disease, infertility, and diabetes have been proposed [1,4]. A survey by Showande et al [5] on staff and students at the University of Ibadan in Africa found that some respondents often consume sour tea with pharmaceuticals such as antibiotics, antihypertensives, antipsychotics, antihyperlipidemics, and antiretrovirals.…”

Section: Introductionmentioning

confidence: 99%

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Pharmacokinetic Herb-Drug Interaction between Hibiscus sabdariffa Calyces Aqueous Extract and Captopril in Rats

Nurfaradilla

Saputri

Harahap

2020

Evidence-Based Complementary and Alternative Medicine

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Hibiscus sabdariffa L. (Malvaceae) is a traditional medicinal herb widely consumed as a beverage (“hibiscus tea”), and its global popularity is expanding due to health benefits such as blood pressure and cholesterol control. Previous studies showed that Hibiscus sabdariffa is coadministered with antihypertensives and antihyperlipidemics, thus predisposing herb-drug interactions. We investigated the pharmacokinetic interaction between H. sabdariffa L. aqueous extract and captopril, a frequently prescribed antihypertensive. In this study, chemical profile of H. sabdariffa L. aqueous extract was identified using HPLC system equipped with a DAD detector at 360 nm and 520 nm. The male Sprague Dawley rats were divided into two groups of six rats. Group I received a single dose of captopril suspension (4.5 mg/200 g body weight (BW) orally (p.o.)) while group II received H. sabdariffa L. aqueous extract (60 mg/200 g BW; p.o.) daily for two weeks prior to the same captopril dose. Multiple blood samples were collected at predetermined times after captopril administration and the plasma concentration was analyzed using ultrahigh-pressure liquid chromatography-tandem mass spectrometry. Chemical profiling of the H. sabdariffa L. aqueous extract showed that the extract contains chlorogenic acid, myricetin 3-arabinogalactoside, 5-O-caffeoylshikimic acid, quercetin 3-rutinoside, delphinidin 3-sambubioside, and cyanidin 3-sambubioside. Ingestion of the extract significantly reduced the captopril area under the curve (AUC)0−t (0.1745 (0.1254–0.2429)), AUC0−∞ (0.1734 (0.1232–0.2442))], and peak plasma concentration (0.2119 (0.1337–0.3359)) (geometric mean ratio of the coadministration group to the captopril group (90% CI)). The geometric mean ratios were falling outside the 90% CI of 0.8–1.25 bioequivalent range. Conversely, H. sabdariffa L. extract increased the apparent total body clearance (Cl/F, 0.0257 ± 0.0115 vs. 0.1418 ± 0.0338 mL/h·kg) and the apparent volume of distribution (Vd/F, 0.0541 ± 0.0226 vs. 0.3205 ± 0.0790 mL/kg). This study indicated that coadministration of H. sabdariffa L. aqueous extract could change the pharmacokinetic profile of captopril; therefore, its coadministration should be avoided.

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In vivo pharmacodynamic and pharmacokinetic interactions ofHibiscus sabdariffacalyces extracts with simvastatin

Cited by 18 publications

References 29 publications

Effects of Hibiscus Sabdariffa Calyces Aqueous Extract on the Antihypertensive Potency of Captopril in the Two-Kidney-One-Clip Rat Hypertension Model

Effects of Hibiscus Sabdariffa Calyces Aqueous Extract on the Antihypertensive Potency of Captopril in the Two-Kidney-One-Clip Rat Hypertension Model

Effect of Hibiscus sabdariffa (Roselle) supplementation in regulating blood lipids among patients with metabolic syndrome and related disorders: A systematic review and meta‐analysis

Pharmacokinetic Herb-Drug Interaction between Hibiscus sabdariffa Calyces Aqueous Extract and Captopril in Rats

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