Effect of Hibiscus sabdariffa (Roselle) supplementation in regulating blood lipids among patients with metabolic syndrome and related disorders: A systematic review and meta‐analysis

Abstract

This study aimed to assess the efficacy of Hibiscus sabdariffa (Roselle) in regulating blood lipids among patients with metabolic syndrome and related disorders. PubMed, the Cochrane Library, Embase, Web of Science, and Clinical Trials were searched to identify the randomised controlled trials meeting the inclusion criteria. Study selection, data extraction, and risk assessment were performed according to Cochrane handbook; available data were analysed using STATA 15.0 software. Eventually, nine trials involving 503 participants were included in this meta-analysis. The results showed that compared with the control group, H. sabdariffa supplementation could reduce total cholesterol (WMD = −14.66; 95% CI [−18.22, −11.10]; p = .000; I 2 = 46.9%) and low-density lipoprotein cholesterol (WMD = −9.46; 95% CI [−14.93, −3.99]; p = .001; I 2 = 50.1%) but could not effectively reduce triglyceride (WMD = −0.77; 95% CI [−7.87, 6.33]; p = 0.832; I 2 = 0%). Meanwhile, there were no serious adverse reactions reported in the included studies. To summarise, current evidence suggests that the benefits of H. sabdariffa supplementation to patients with metabolic diseases are associated with its cholesterol-lowering effects; however, more high-quality clinical trials are needed to confirm these results. K E Y W O R D Sblood lipids, dyslipidemia, Hibiscus sabdariffa, meta-analysis, metabolic syndrome

Effect of sour tea supplementation on liver enzymes, lipid profile, blood pressure, and antioxidant status in patients with non‐alcoholic fatty liver disease: A double‐blind randomized controlled clinical trial

“…They have showed that sour tea can reduce cholesterol biosynthesis by inhibiting 3-hydroxy-3-methylglutarylcoenzyme A (HMG-CoA) reductase, which catalyzes the conversion of HMG-CoA to mevalonic acid, a necessary step in cholesterol biosynthesis, and can suppress TG synthesis (Duangjai et al, 2011;Yang et al, 2010). Sour tea flavonoids have a strong anti-oxidative activity on the liver, and they can affect the metabolism and production of lipids (Najafpour Boushehri et al, 2020;Zhang et al, 2019).…”

Phytonutrient supplements and metabolic biomarkers of cardiovascular disease: An umbrella review of meta‐analyses of clinical trials

“…Thirteen of these studies were excluded because they included an abstract ( N = 5) or a protocol ( N = 1) only, were not published in English ( N = 1), had inappropriate exposures ( N = 2) or outcomes ( N = 1), or did not provide updated data ( N = 2). As a result, 50 systematic reviews and meta‐analyses were included in the final analysis (Figure 1; Amir Shaghaghi et al, 2013; Askari et al, 2019; Azhdari et al, 2019; Chen et al, 2020; Fatahi et al, 2019; Ghaedi et al, 2019; Ghaedi et al, 2020; Glisic et al, 2018; Gui et al, 2016; Hadi et al, 2018, 2020; Hadi, Pourmasoumi, Mohammadi, et al, 2019; Hadi, Pourmasoumi, Najafgholizadeh, et al, 2019; Hallajzadeh et al, 2020; Hamedifard et al, 2019; Han et al, 2019; Hasani et al, 2019; Hemati et al, 2020; Hernández‐García et al, 2019; Heshmat‐Ghahdarijani et al, 2020; Karimian et al, 2019; Khorshidi et al, 2020; Li et al, 2014, 2015, 2020; Maierean et al, 2017; Mansour‐Ghanaei et al, 2018; Mohammadi, Hadi, et al, 2019; Mohammadi, Ramezani‐Jolfaie, et al, 2019; Ostadmohammadi et al, 2019; Pourmasoumi et al, 2018, 2020; Rahmani et al, 2019; Rahmani et al, 2020; Ricci et al, 2010; Ried, 2016; Rocha et al, 2019; Sahebkar, 2014; Sahebkar, Simental‐Mendía, et al, 2016; Sahebkar, Soranna, et al, 2016; Salehi‐Sahlabadi et al, 2020; Serban et al, 2015; Shekarchizadeh‐Esfahani et al, 2020; Taku et al, 2010; Ursoniu et al, 2018; Zhang et al, 2020; Zhang, Yuan, et al, 2016; Zhang, Liu, et al, 2016; Zhu et al, 2017; Ziaei et al, 2020).…”

Targeting dyslipidemia by herbal medicines: A systematic review of meta-analyses

“…Simultaneous increment of health problems led into the attraction of global attention. Atherosclerosis, cardiovascular complications, pancreas disorders, and fatty liver are avowed as the concurrent disease with DLP (Zhang et al, 2020). Likewise, DLP is associated with metabolic syndrome (Mets) and its components such as obesity and diabetes (Tabatabaei-Malazy et al, 2015).…”

“…Diverse approaches are recommended to manage DLP; such as lifestyle modifications, diet intervention, and pharmacotherapy options (Shekarchizadeh-Esfahani et al, 2020). The more efforts do for the management of DLP, the less beneficial results the patients receive (Zhang et al, 2020). Despite the worldwide use of lipid-lowering agents, their long-term efficacy is still questionable (Shekarchizadeh-Esfahani et al, 2020).…”

“…Although, hibiscus sabdariffa reduces TC and LDL-C, unexpectedly, it declines the HDL-C serum level too. It may be induced by different genotypes that play role in lipid metabolism (Zhang et al, 2020). Sour tea controls the production of cholesterols and TG by restricting HMG-CoA reductase and stirring discharge of hormones that play role in cholesterol metabolism (Najafpour Boushehri et al, 2020).…”