In vivo PET imaging with [18F]FDG to explain improved glucose uptake in an apolipoprotein A-I treated mouse model of diabetes

Cochran, Blake J.; Ryder, William J.; Tang, Shoufeng; Reilhac, Anthonin; Arthur, Andrew; Charil, Arnaud; Hamze, Hasar; Barter, Philip J.; Kritharides, Leonard; Meikle, Steven R.; Grégoire, Marie‐Claude; Rye, Kerry‐Anne

doi:10.1007/s00125-016-3993-5

Cited by 29 publications

(22 citation statements)

References 40 publications

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“…The LC proportionally affected the precision of the MRGlu value, but not the relative difference between the two groups. PET allows simultaneous measurements of radiotracer uptake and tissue kinetics in multiple organs [ 50 – 52 ]. However, we did not compare skeletal muscle due to higher background activity after intraperitoneal 18 F-FDG injection.…”

Section: Discussionmentioning

confidence: 99%

Longitudinal evaluation of myocardial glucose metabolism and contractile function in obese type 2 diabetic db/db mice using small-animal dynamic 18F-FDG PET and echocardiography

Liu

et al. 2017

Oncotarget

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The aim was to evaluate sequential changes of myocardial glucose utilization and LV systolic function in db/db mice.Eight db/db and eight wild-type mice underwent plasma substrate analysis and dynamic 18F-FDG PET at week 8 (W8), W10, W12, W14, and W16. 18F-FDG uptake constant Ki and the rate of myocardial glucose uptake (MRGlu) were derived via Patlak graphic analysis. Another 8 db/db and 8 wild-type mice received echocardiography at W8, W12, and W16 and LV structure and function were measured.The db/db mice showed increased weights and glucose levels as they aged. The index of homeostasis model assessment-estimated insulin resistance, insulin, and free fatty acid concentrations were higher in db/db mice compared with wild-type. MRGlu of db/db mice across all time points was markedly higher than that of wild-type. An age-dependent elevation of MRGlu was observed in db/db mice. Ki and MRGlu of db/db mice showed negative correlation with triglyceride levels. When two groups were pooled together, Ki and MRGlu were significantly proportional to glucose levels. No significant difference in LV structure and function was noted between db/db and control mice.In conclusion, we demonstrated altered myocardial glucose utilization preceding the onset of LV systolic dysfunction in db/db mice.

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Section: Discussionmentioning

confidence: 99%

Longitudinal evaluation of myocardial glucose metabolism and contractile function in obese type 2 diabetic db/db mice using small-animal dynamic 18F-FDG PET and echocardiography

Liu

et al. 2017

Oncotarget

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“…This has been described as the major atheroprotective effect of apoA-I 1 . Other beneficial effects of the apoA-I protein, including its anti-thrombotic and anti-oxidant functions, and a positive influence of apoA-I/HDL on glucose control, with potential implications in the prevention and treatment of diabetes, have also been demonstrated 2 – 6 . These features of the apoA-I protein have spurred large interests in exploring the translational medicine potential in cardiovascular disease and diabetes 7 , 8 .…”

Section: Introductionmentioning

confidence: 99%

Synchrotron radiation circular dichroism spectroscopy reveals structural divergences in HDL-bound apoA-I variants

Giudice

Nilsson

Domingo-Espín

et al. 2017

Sci Rep

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Apolipoprotein A-I (apoA-I) in high-density lipoprotein (HDL) provides cardiovascular protection. Synchrotron radiation circular dichroism (SRCD) spectroscopy was used to analyze the dynamic solution structure of the apoA-I protein in the apo- and HDL-states and the protein structure conversion in HDL formation. Wild-type apoA-I protein was compared to human variants that either are protective (R173C, Milano) or lead to increased risk for ischaemic heart disease (A164S). Comparable secondary structure distributions in the HDL particles, including significant levels of beta strand/turn, were observed. ApoA-I Milano in HDL displayed larger size heterogeneity, increased protein flexibility, and an altered lipid-binding profile, whereas the apoA-I A164S in HDL showed decrease thermal stability, potentially linking the intrinsic HDL propensities of the variants to disease risk.

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“…Both HDLs and apoA-I increase the synthesis and secretion of insulin in pancreatic beta cells (112,113). They also enhance glucose uptake by skeletal muscle (114)(115)(116), and thus improve insulin sensitivity. An increase in either, or both, of these HDL functions in people treated with a CETP inhibitor could explain the improvement in glycemic control and decreased risk of developing diabetes that was observed in these studies.…”

Section: Reveal Trial With Anacetrapibmentioning

confidence: 99%

Cholesteryl ester transfer protein and its inhibitors

Shrestha

Guiney

et al. 2018

Journal of Lipid Research

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In vivo PET imaging with [18F]FDG to explain improved glucose uptake in an apolipoprotein A-I treated mouse model of diabetes

Cited by 29 publications

References 40 publications

Longitudinal evaluation of myocardial glucose metabolism and contractile function in obese type 2 diabetic db/db mice using small-animal dynamic 18F-FDG PET and echocardiography

Longitudinal evaluation of myocardial glucose metabolism and contractile function in obese type 2 diabetic db/db mice using small-animal dynamic 18F-FDG PET and echocardiography

Synchrotron radiation circular dichroism spectroscopy reveals structural divergences in HDL-bound apoA-I variants

Cholesteryl ester transfer protein and its inhibitors

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