In vivo osteogenesis of plasma sprayed ternary-ion doped hydroxyapatite coatings on Ti6Al4V for orthopaedic applications

Ratha, Itishree; Datta, Pradyot; Reger, N.; Das, Himanka; Balla, Vamsi Krishna; Devi, K. Bavya; Roy, Mousumi; Nandi, Samit Kumar; Kundu, Biswanath

doi:10.1016/j.ceramint.2022.01.004

Cited by 19 publications

(8 citation statements)

References 68 publications

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“…The SBF immersion test has the ability to classify various alternative biomaterials quickly and cheaply 45 . The success of this type of assay can be verified in other studies [46][47][48][49][50][51] , being considered the most appropriate in vitro method to investigate the bioactivity of materials whose aim is to promote bone bonding and regeneration 49 .…”

Section: Resultsmentioning

confidence: 79%

Influence of Reactive Sputtering-Deposited Nb2O5 Coating On the Ti-6Al-4V Alloy Surfaces: Biomineralization, Antibacterial Activity, and Cell Viability Tests

Nascimento,

Teixeira,

Obata

et al. 2023

Mat. Res.

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Biomedical engineering has been constantly looking for the development of new materials that have bioactive surfaces and that are responsible for new bone formation, induce osteoblast differentiation and present antibacterial properties. Here, we present innovative and applied research to evaluate the influence of niobium pentoxide thin films (Nb 2 O 5 ) deposited on the surface of a Ti-6Al-4V alloy via the reactive sputtering technique on antibacterial activity, on the cellular proliferation of MC3T3 cells and on biomineralization capacity. Results demonstrated the reactive sputtering technique improved the cell viability, the osteogenic performance of cells involved in the osseointegration process, the ability to delay bacterial proliferation within the first six hours of contact with S. aureus as well as the capacity to promote rapid amorphous apatite formation in vitro. These findings confirm the great potential of the Ti-6Al-4V alloy functionalized with Nb 2 O 5 for future applications in implantable devices.

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Section: Resultsmentioning

confidence: 79%

Influence of Reactive Sputtering-Deposited Nb2O5 Coating On the Ti-6Al-4V Alloy Surfaces: Biomineralization, Antibacterial Activity, and Cell Viability Tests

Nascimento,

Teixeira,

Obata

et al. 2023

Mat. Res.

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“…PLA/HA, 188 Ti/HA, 200 Zr/HA 200 Wear-resistant In bone joint replacement, the material should resist friction and not elicit wear particles into the body Graphene/HA, 201 CNT/HA, 16 CNT/Al 2 O 3 , 202 CNT/TiO 2 , 202 ND, 203 CNT/ferrogel 204 Al 2 O 3 /HA 6Al-4V implant could not fill the bone gap even after 2 months. 230 Despite the clinical success, being brittle, synthetic HA exhibits inferior mechanical and tribological properties as compared to bone, especially showing very poor surface mechanical properties such as low fracture toughness, bending strength, bonding strength, tensile strength, and wear resistance. HA-modified biomaterials surfaces are also susceptible to bacterial colonization.…”

Section: Wettabilitymentioning

confidence: 99%

“…Bioglass incorporation deteriorated adhesion strength due to the induction of viscosity and brittleness. 423 Very recently, Ratha et al 230 performed an in vivo investigation of multi-material (Sr 2+ , Zn 2+ , F − with HA and Sr 2+ , Zn 2+ , Ag + with HA)-reinforced HA composite coatings deposited using the plasma spray technique. After observations for 2 months (in a rabbit model), ∼60% bone growth was observed as compared to bare titanium, whereas only ∼40% bone growth was observed in HA coatings.…”

Section: Challenges and Future Scope Of Workmentioning

confidence: 99%

Bioactive surface modifications through thermally sprayed hydroxyapatite composite coatings: a review of selective reinforcements

et al. 2022

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“…Many parameters involved in this method, which can potentially affect the microstructure of coatings. Plasma spray was highly irregular in form, but it can stimulate osteoblast differentiation in vitro and support osteogenesis in vivo ( Ratha et al, 2022 ; Udduttula et al, 2022 ). Liu et al proposed a novel vapor-induced poreforming atmospheric plasma spraying to prepare bioactive porous HA coating with the potential to promote osteoblast attachment and differentiation ( Liu et al, 2020b ).…”

Section: Strategies Of Surface Topology Modificationmentioning

confidence: 99%

Effect of microtopography on osseointegration of implantable biomaterials and its modification strategies

Zhang

Fan

Xing

et al. 2022

Front. Bioeng. Biotechnol.

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Orthopedic implants are widely used for the treatment of bone defects caused by injury, infection, tumor and congenital diseases. However, poor osseointegration and implant failures still occur frequently due to the lack of direct contact between the implant and the bone. In order to improve the biointegration of implants with the host bone, surface modification is of particular interest and requirement in the development of implant materials. Implant surfaces that mimic the inherent surface roughness and hydrophilicity of native bone have been shown to provide osteogenic cells with topographic cues to promote tissue regeneration and new bone formation. A growing number of studies have shown that cell attachment, proliferation and differentiation are sensitive to these implant surface microtopography. This review is to provide a summary of the latest science of surface modified bone implants, focusing on how surface microtopography modulates osteoblast differentiation in vitro and osseointegration in vivo, signaling pathways in the process and types of surface modifications. The aim is to systematically provide comprehensive reference information for better fabrication of orthopedic implants.

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In vivo osteogenesis of plasma sprayed ternary-ion doped hydroxyapatite coatings on Ti6Al4V for orthopaedic applications

Cited by 19 publications

References 68 publications

Influence of Reactive Sputtering-Deposited Nb2O5 Coating On the Ti-6Al-4V Alloy Surfaces: Biomineralization, Antibacterial Activity, and Cell Viability Tests

Influence of Reactive Sputtering-Deposited Nb2O5 Coating On the Ti-6Al-4V Alloy Surfaces: Biomineralization, Antibacterial Activity, and Cell Viability Tests

Bioactive surface modifications through thermally sprayed hydroxyapatite composite coatings: a review of selective reinforcements

Effect of microtopography on osseointegration of implantable biomaterials and its modification strategies

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