In vivo observation of living cancer cells in the esophagus, stomach, and colon using catheter-type contact endoscope, “Endo-Cytoscopy system”

Inoue, Haruhiro; Kazawa, Tamae; Sato, Yoshitaka; Satodate, Hitoshi; Sasajima, Keita; Kudo, Shin‐ei; Shiokawa, Akira

doi:10.1016/j.giec.2004.03.013

Cited by 100 publications

(78 citation statements)

References 3 publications

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“…In some cases, follicular gastritis may be observed, especially in children and young adults (474), as well as major lesions, e.g., ulcers, polyps, tumors. However, recent progress has been made to magnify the gastric mucosal abnormalities with narrow band imaging (260), endocytoscopy (231), and confocal laser endomicroscopy (257). This last technique enabled detection of H. pylori by surface microscopy imaging of living tissue during ongoing endoscopy for the first time.…”

Section: Invasive Testsmentioning

confidence: 99%

Helicobacter pyloriDetection and Antimicrobial Susceptibility Testing

2007

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SUMMARY The discovery of Helicobacter pylori in 1982 was the starting point of a revolution concerning the concepts and management of gastroduodenal diseases. It is now well accepted that the most common stomach disease, peptic ulcer disease, is an infectious disease, and all consensus conferences agree that the causative agent, H. pylori, must be treated with antibiotics. Furthermore, the concept emerged that this bacterium could be the trigger of various malignant diseases of the stomach, and it is now a model for chronic bacterial infections causing cancer. Most of the many different techniques involved in diagnosis of H. pylori infection are performed in clinical microbiology laboratories. The aim of this article is to review the current status of these methods and their application, highlighting the important progress which has been made in the past decade. Both invasive and noninvasive techniques will be reviewed.

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Section: Invasive Testsmentioning

confidence: 99%

Helicobacter pyloriDetection and Antimicrobial Susceptibility Testing

2007

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“…Any endoscope with a 3.7-mm working channel may serve as a mother endoscope, which then allows the insertion of the baby scope 'Endo-Cytoscope'. Under topical pharyngeal anesthesia, a therapeutic endoscope (GIF-1T, Olympus) is fi rst introduced to the upper gastrointestinal tract [5,6] . In case of assessment of the colon, a colonoscope is introduced into the site.…”

Section: Endocytoscopymentioning

confidence: 99%

Novel Endoscopic Imaging Techniques toward in vivo Observation of Living Cancer Cells in the Gastrointestinal Tract

Inoue

Kudo

Shiokawa

2004

Dig Dis

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Recent advances in endoscopic imaging technology have enabled the visualization of cellular-level microstructures of early-stage cancer and its precursors. Chromoendoscopy, magnifying endoscopy, endoscopic optical coherent tomography (EOCT) spectroscopy, and various combinations of these technologies, are all important for the recognition of small and unclear lesions. In order to observe cancer cells in vivo two types of ultra-high magnifying endoscope – ‘laser-scanning confocal laser-scanning endoscopy series’ and ‘contact endoscopy series’ – that have a maximum of >1,000 times magnifying power have been developed. The use of these endoscopes has allowed the generation of high quality images of both living cancer cells and normal cells in the gastrointestinal tract. In particular, clear images of cells and their nuclei, equivalent to the high quality that is possible with conventional cytology, have been produced. These novel imaging technologies may make in vivo histological diagnosis by virtual histology possible.

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“…Recent advances in endoscopic diagnostic techniques such as magnifying endoscopy [3][4][5] have allowed ultra-microcarcinomas of 1 mm to be detected 6 , and prognoses have thereby been changed to a large degree by the early diagnoses of esophageal cancer.…”

Section: Discussionmentioning

confidence: 99%

“…However, it is often dif cult to differentiate these lesions in a biopsy. In addition, recent advances in diagnostic techniques using magnifying endoscopes and endoscopes [3][4][5] has also de ned ultra-microcarcinomas of 1 mm 6 . These factors and that esophageal cancer is a possible causal factor in elderly cases of dysphagia make early detection even more important.…”

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confidence: 99%

An Immunohistological Study on Intraepithelial Lesions in Esophagus

Yamazaki

Saito

Mori

et al. 2009

Showa Univ J Med Sci

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IntroductionEsophageal epithelial lesions are important early indicators of esophageal cancer. Esophageal epithelial lesions include inflammatory reactive IR lesions and neoplastic lesions. Abstract : Esophageal epithelial lesions are important features with respect to the early diagnosis of esophageal cancer. Such lesions include in ammatory reactive lesions in ammatory reactions, IR and neoplastic lesions. However, while neoplastic lesions are also classi ed from low-grade intraepithelial neoplasia LN to high-grade intraepithelial neoplasia HN , it is often difficult to differentiate esophageal epithelial lesions in a biopsy. Therefore, this study analyzed cases of endoscopic mucosal resection EMR and dissection by immunostaining for p53, MIB-1, glucose transporter-1 GLUT-1 , and cytokeratin CK in addition to cytohistological grading to establish lesions trends for classi cation. This study included 50 lesions of EMR performed at our hospital from 2004 to 2007, as well as 31 cases who underwent a pathological autopsy at our hospital during the period between 2006 and 2007. Tissue diagnoses by HE staining classi ed the specimens into ve groups: normal, IR, LN, HN, and squamous cell cancer SCC . This study undertook further comparison by immunostaining for p53, Ki-67 staining, GLUT-1 and CKs 17 and 14. All immunostaining revealed a signi cant difference between IR and LN grade of lesions. Speci cally, GLUT-1 staining revealed a signi cant difference between LN and HN lesions, while CK17 staining differentiated signi cantly between HN and SCC. The ndings indicated that pathological diagnoses of esophageal lesions should include GLUT-1, CK17, and CK14 immunostaining to differentiate LN and HN lesions.

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In vivo observation of living cancer cells in the esophagus, stomach, and colon using catheter-type contact endoscope, “Endo-Cytoscopy system”

Cited by 100 publications

References 3 publications

Helicobacter pyloriDetection and Antimicrobial Susceptibility Testing

Helicobacter pyloriDetection and Antimicrobial Susceptibility Testing

Novel Endoscopic Imaging Techniques toward in vivo Observation of Living Cancer Cells in the Gastrointestinal Tract

An Immunohistological Study on Intraepithelial Lesions in Esophagus

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