In vivo multifunctional fluorescence imaging using liposome-coated lanthanide nanoparticles in near-infrared-II/IIa/IIb windows

Yang, Junying; He, Shuqing; Hu, Zhenhua; Zhang, Zeyu; Cao, Chuanxiang; Cheng, Zhen; Fang, Chihua; Hui, Hui

doi:10.1016/j.nantod.2021.101120

Cited by 57 publications

(45 citation statements)

References 53 publications

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“…The in vivo half-life of Nd-RENPs in the liver was calculated as 15.8 h (Fig. 4b), which is signi cant short than the similar nanoprobes reported previously [9,25,39] and close to that reported by Yang and co-workers [40]. In addition, the pharmacokinetic results presented in Fig.…”

Section: In Vivo Pharmacokinetics Of Nd-renpssupporting

confidence: 77%

Rational Designed Rapid Liver Clearance Rare-earth Core-shell Nanoprobe for Dual-Modal Breast Cancer Imaging in the Second Near-Infrared Window

Wei

Duan²,

Huang³

et al. 2021

Preprint

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BackgroundFluorescence imaging as the beacon for optical navigation has wildly developed in preclinical studies due to its prominent advantages, including noninvasiveness and superior temporal resolution. However, the traditional optical methods based on ultraviolet (UV, 200-400 nm) and visible light (Vis, 400-650 nm) limited by their low penetration, signal-to-noise ratio, and high background auto-fluorescence interference. Therefore, the development of near-infrared-II (NIR-II 1000-1700 nm) nanoprobe attracted significant attentions toward in vivo imaging. Regrettably, most of the NIR-II fluorescence probes, especially for inorganic NPs, were hardly excreted from the reticuloendothelial system (RES), yielding the anonymous long-term circulatory safety issue. ResultsHere, we develop a facile strategy for the fabrication of Nd3+-doped rare-earth core-shell nanoparticles (Nd-RENPs), NaGdF4:5%Nd@NaLuF4, with strong emission in the NIR-II window. What’s more, the Nd-RENPs could be quickly eliminated from the hepatobiliary pathway, reducing the potential risk with the long-term retention in the RES. Further, the Nd-RENPs are successfully utilized for NIR-II in vivo imaging and magnetic resonance imaging (MRI) contrast agents, enabling the precise detection of breast cancer. ConclusionsThe rational designed Nd-RENPs nanoprobes manifest rapid-clearance property revealing the potential application toward the noninvasive preoperative imaging of tumor lesions and real-time intra-operative supervision.

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Section: In Vivo Pharmacokinetics Of Nd-renpssupporting

confidence: 77%

Rational Designed Rapid Liver Clearance Rare-earth Core-shell Nanoprobe for Dual-Modal Breast Cancer Imaging in the Second Near-Infrared Window

Wei

Duan²,

Huang³

et al. 2021

Preprint

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“…The NIR-II fluorescence quantum yield of the IR1061@HSA nanoparticles was measured following the procedure described previously [ 38 ]. Briefly, IR26 was used as a reference fluorophore (QY = 0.5%).…”

Section: Methodsmentioning

confidence: 99%

“…Different concentrations of IR26 solutions and IR1061@HSA nanoparticles dispersions with an OD < 0.1 at 808 nm were prepared, and then the absorbance at 808 nm and the fluorescent intensity values were measured. The quantum yield was calculated according to the previously reported equation [ 38 ].…”

Section: Methodsmentioning

confidence: 99%

J-aggregates albumin-based NIR-II fluorescent dye nanoparticles for cancer phototheranostics

Liu

et al. 2022

Materials Today Bio

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“…Inorganic nanoparticles such as singlewalled carbon nanotubes, quantum dots, and rare-earth nanocrystals have been utilized as very promising imaging nanoprobes for preclinical diagnosis and prognosis. [1][2][3] However, such nanoparticles are emission "always on" probes that continuously yield unspecific signals regardless of whether they reach the target locations. [4] In vivo imaging with common inorganic probes usually suffers from poor detection precision resulting from weak target-tobackground ratio.…”

Section: Introductionmentioning

confidence: 99%

Aggregation‐Induced Phosphorescent Imaging in the Second Near‐Infrared Window

Chang

Zhu

et al. 2021

Advanced Optical Materials

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In vivo multifunctional fluorescence imaging using liposome-coated lanthanide nanoparticles in near-infrared-II/IIa/IIb windows

Cited by 57 publications

References 53 publications

Rational Designed Rapid Liver Clearance Rare-earth Core-shell Nanoprobe for Dual-Modal Breast Cancer Imaging in the Second Near-Infrared Window

Rational Designed Rapid Liver Clearance Rare-earth Core-shell Nanoprobe for Dual-Modal Breast Cancer Imaging in the Second Near-Infrared Window

J-aggregates albumin-based NIR-II fluorescent dye nanoparticles for cancer phototheranostics

Aggregation‐Induced Phosphorescent Imaging in the Second Near‐Infrared Window

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