In vivo Lipid Peroxidation Responses of Tissues in Lead-Treated Swiss Mice.

Abstract

A single intraperitoneal injection of lead acetate (200 mg/kg body weight) increased the lipid peroxidation potential (LPP) measured as thiobarbituric acid-reactive substance (TBA-RS) in different tissues of Swiss mice. All the tissues taken for experimentation, generated significantly higher amount of TBA-RS in lead-treated mice when compared with the respective control value. However, none of the tissues could correspond to the control value after the lapse of four weeks posttreatment. Possibilities of differential responsiveness of tissues to generate lipid peroxides in leadtreated mice have been discussed.

Motor behavior and brain enzymatic changes after acute lead intoxication on different strains of mice

“…Lead accumulation has been suggested to generate lipid peroxidation and therefore to affect antioxidant enzymes, including catalase (Somashekaraiah et al, 1992;Acharya and Acharya, 1997). The results obtained in the present study confirm previous data (De Gennaro, 1987;Somashekaraiah et al, 1992;Valenzuela et al, 1989) that have demonstrated the effect of acute lead acetate administration on brain catalase activity.…”

Lead Acetate Induced Cytotoxicity in Male Germinal Cells of Swiss Mice.

“…This is in agreement with our previous findings 14) . Conceptually, reactive oxygen radicals are detrimental to the organ and therefore, are regularly being scavenged by a variety of endogenous antioxidants and quenchers including vitamins, enzymes, tripeptides etc 15) .…”

Cumulative Exposure to Lead in Relation to Cognitive Function in Older Women

“…Chiefly, lead can damage and eventually kill neurons through its oxidative toxicity, whereby lead both induces oxidative stress (Acharya and Acharya 1997; Adonaylo and Oteiza 1999b) and impedes responses to oxidative stress (Adonaylo and Oteiza 1999a; Ercal et al 1996) in the brain. Oxidative stress, in turn, appears to be integral to the pathogenesis of cognitive decline and dementia (Andersen 2004; Markesbery and Lovell 2007).…”