Motor behavior and brain enzymatic changes after acute lead intoxication on different strains of mice

Correa, Mercè; Roig-Navarro, A.F.; Aragón, Carlos M.G.

doi:10.1016/j.lfs.2003.08.042

Cited by 32 publications

(17 citation statements)

References 29 publications

(42 reference statements)

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“…Consistent with previous studies involving peripheral administration of ethanol in mice (Aragon et al, 1992a;Aragon and Amit, 1993;Correa et al, 1999aCorrea et al, , b, 2000Correa et al, , 2001Correa et al, , 2004aSanchis-Segura et al, 1999a-c;Pastor et al, 2002), the present studies suggest that the metabolism of ethanol into acetaldehyde is involved in the locomotor stimulant effects of ethanol. In experiment 3, the locomotor effects of intranigral ethanol were blocked by peripheral administration of sodium azide, a catalase inhibitor that acts to reduce brain ethanol metabolism Correa et al, 2004b).…”

Section: Role Of Ethanol Metabolismsupporting

confidence: 92%

“…Nevertheless, some acetaldehyde can be directly formed in the brain through the actions of catalase (Aragon et al, 1992b;Reddy et al, 1995;Zimatkin and Lindros, 1996;Hamby-Mason et al, 1997;Eysseric et al, 1997;Zimatkin et al, 1998). The notion that ethanol metabolism in the brain is important for some of the behavioral effects of ethanol is supported by the reports that manipulations of catalase activity exert a powerful effect on ethanol-induced behavior (Aragon et al, 1992a;Aragon and Amit, 1993;Correa et al, 1999aCorrea et al, , b, 2000Correa et al, , 2001Correa et al, , 2004aSanchis-Segura et al, 1999a-c;Pastor et al, 2002). Additional support is provided by studies showing behavioral effects of acetaldehyde after central administration (Myers and Veale, 1969;Brown et al, 1978Brown et al, , 1979Brown et al, , 1980Smith et al, 1984;Arizzi et al, 2003;Correa et al, 2003b, c;Rodd-Henricks et al, 2002;Rodd et al, 2005).…”

Section: Role Of Ethanol Metabolismmentioning

confidence: 99%

“…Mice lacking catalase have lower levels of ethanol-induced locomotion than control animals (Aragon et al, 1992a;Aragon and Amit, 1993), and across several pharmacological manipulations there is a high positive correlation between ethanol-induced locomotor activity and brain catalase activity (Correa et al, , b, 2000(Correa et al, , 2001(Correa et al, , 2004aSanchis-Segura et al, 1999a-c;Pastor et al, 2002). Because catalase has been strongly implicated in ethanol metabolism in the brain (Aragon et al, 1991(Aragon et al, , 1992bGill et al, 1992), it is reasonable to suggest that this enzyme may regulate the motor effects of ethanol through a mechanism tied to the rate of cerebral acetaldehyde production (Aragon et al, 1989(Aragon et al, , 1991(Aragon et al, , 1992b.…”

Section: Introductionmentioning

confidence: 99%

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Motor Stimulant Effects of Ethanol Injected into the Substantia Nigra Pars Reticulata: Importance of Catalase-Mediated Metabolism and the Role of Acetaldehyde

Arizzi-LaFrance

Correa

Aragón

et al. 2005

Neuropsychopharmacol

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A series of experiments was conducted to investigate the locomotor effects of local injections of ethanol and the ethanol metabolite, acetaldehyde, into substantia nigra pars reticulata (SNr). Infusions of ethanol into SNr resulted in a dose-related increase in locomotor activity, with maximal effects at a dose of 1.4 mmol. Ethanol injected into a control site dorsal to substantia nigra failed to stimulate locomotion, and another inactive site was identified in brainstem areas posterior to substantia nigra. The locomotor effects of intranigral ethanol (1.4 mmol) were reduced by coadministration of 10 mg/kg sodium azide, a catalase inhibitor that acts to reduce the metabolism of ethanol into acetaldehyde in the brain. SNr infusions of acetaldehyde, which is the first metabolite of ethanol, also increased locomotion. Taken together, these results indicate that SNr is one of the sites at which ethanol and acetaldehyde may be acting to induce locomotor activity. These results are consistent with the hypothesis that acetaldehyde is a centrally active metabolite of ethanol, and provide further support for the idea that catalase activity is a critical step in the regulation of ethanol-induced motor activity. These studies have implications for understanding the brain mechanisms involved in mediating the ascending limb of the biphasic dose-response curve for the effect of ethanol on locomotor activity.

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Section: Role Of Ethanol Metabolismsupporting

confidence: 92%

Section: Role Of Ethanol Metabolismmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Motor Stimulant Effects of Ethanol Injected into the Substantia Nigra Pars Reticulata: Importance of Catalase-Mediated Metabolism and the Role of Acetaldehyde

Arizzi-LaFrance

Correa

Aragón

et al. 2005

Neuropsychopharmacol

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“…When released into aquatic media, it causes several morphological, structural, physiological, biochemical and behavioral effects on aquatic organisms (WHO, 1995). A remarkable characteristic of lead poisoning is damage to the central nervous, hematopoitic, renal and immune systems (Correa et al, 2004). Hence, fish contamination by toxic metals has received much attention.…”

Section: Introductionmentioning

confidence: 99%

FT-IR study of the effect of lead and the influence of chelating agents, DMSA and D-Penicillamine, on the biochemical contents of brain tissues of Catla catla fingerlings

2008

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The goal of this study was to investigate the effect of lead and the influence of chelating agents, meso 2, 3-dimercaptosuccinic acid (DMSA) and DPenicillamine, on the biochemical contents of the brain tissues of Catla catla fingerlings by Fourier Transform Infrared Spectroscopy. FT-IR spectra revealed significant differences in absorbance intensities between control and lead-intoxicated brain tissues, reflecting a change in protein and lipid contents in the brain tissues due to lead toxicity. In addition, the administration of chelating agents, DMSA and DPenicillamine, improved the protein and lipid contents in the brain tissues compared to lead-intoxicated tissues. Further, DMSA was more effective in reducing the body burden of lead. The protein secondary structure analysis revealed that lead intoxication causes an alteration in protein profile with a decrease in a-helix and an increase in b-sheet structure of Catla catla brain. In conclusion, the study demonstrated that FT-IR spectroscopy could differentiate the normal and lead-intoxicated brain tissues due to intrinsic differences in intensity.

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“…Correa et al compared motor behavior and enzymatic changes in the brains of outbred Swiss or CD1, and inbred BALB/c, C57BL/J6 or DBA/2 mice after acute lead intoxication [21]. None of the strains differed after exposure to saline or lead.…”

mentioning

confidence: 99%

Strain-Dependent Differences in Locomotor Activity after Local Brain Irradiation with 30 GyE of Carbon Ions

Iwakawa¹,

Takai

Goto³

et al. 2005

Exp. Anim.

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Motor behavior and brain enzymatic changes after acute lead intoxication on different strains of mice

Cited by 32 publications

References 29 publications

Motor Stimulant Effects of Ethanol Injected into the Substantia Nigra Pars Reticulata: Importance of Catalase-Mediated Metabolism and the Role of Acetaldehyde

Motor Stimulant Effects of Ethanol Injected into the Substantia Nigra Pars Reticulata: Importance of Catalase-Mediated Metabolism and the Role of Acetaldehyde

FT-IR study of the effect of lead and the influence of chelating agents, DMSA and D-Penicillamine, on the biochemical contents of brain tissues of Catla catla fingerlings

Strain-Dependent Differences in Locomotor Activity after Local Brain Irradiation with 30 GyE of Carbon Ions

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