In-vivo laxative and toxicological evaluation and in-vitro antitumour effects of <i>Mitracarpus frigidus</i> aerial parts

Fabri, Rodrigo Luiz; Aragão, Danielle Maria de Oliveira; Florêncio, Jônatas Rodrigues; Cardoso, Gabriele Mendes Matos; Souza-Fagundes, Elaine M.; Castañon, Maria Christina Marques Nogueira; Scio, Elita

doi:10.1111/j.2042-7158.2011.01420.x

Cited by 12 publications

(4 citation statements)

References 24 publications

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“…The methanolic extract of aerial parts (MFM) revealed the presence of flavonoids, tannins, alkaloids, terpenes, and quinones and showed antimicrobial, leishmanicidal, cytotoxic, and laxative activities. Moreover, MFM revealed no toxicity signs in rat models [22, 23]. Recently, the pyranonaphthoquinone psychorubrin was firstly isolated from this species [24].…”

Section: Introductionmentioning

confidence: 99%

Chromatographic Fingerprint Analysis and Effects of the Medicinal Plant SpeciesMitracarpus frigiduson AdultSchistosoma mansoniWorms

Fabri

Aragão

Florêncio

et al. 2014

BioMed Research International

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The aims of this work were to evaluate the in vitro and in vivo schistosomicidal properties of the methanolic extract of the aerial parts of Mitracarpus frigidus (MFM) and to determine its HPLC profile. For the in vitro experiment, four pairs of adult worms, obtained from infected mice, were exposed to different concentrations of MFM (100 to 400 μg/mL) for 24 and 48 h and analyzed under an inverted microscope. For the in vivo experiment, mice were inoculated with cercariae and, 20 days after infection, MFM (100 and 300 mg/kg) was administered orally for the following 25 days. Mice were euthanized after 60 days. MFM showed in vitro schistosomicidal activity, exhibiting the opening of the gynaecophoral canal of some male schistosomes, the presence of contorted muscles, vesicles, and the darkening of the paired worms skin. In vivo experiments showed that MFM treatments significantly reduced total worm count, as praziquantel, showing a decrease in liver and spleen weight. Also, a significant reduction in granuloma density was observed. MFM treatment did not cause alterations in the liver function of either infected or noninfected mice. The HPLC chromatogram profile showed the presence of kaempferol-O-rutinoside, rutin, kaempferol, psychorubrin, and ursolic acid.

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Section: Introductionmentioning

confidence: 99%

Chromatographic Fingerprint Analysis and Effects of the Medicinal Plant SpeciesMitracarpus frigiduson AdultSchistosoma mansoniWorms

Fabri

Aragão

Florêncio

et al. 2014

BioMed Research International

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“…Recently, the pyranonaphthoquinone psychorubrin was first isolated from this extract [8]. Moreover, MFM revealed no toxicity signs in rat models [7]…”

Section: Introductionmentioning

confidence: 99%

“…[5] Previous studies showed that the methanolic extract obtained from this plant (MFM) revealed the presence of flavonoids, tannins, alkaloids, terpenes and quinones, and presented antimicrobial, leishmanicidal, cytotoxic and laxative activities. [6,7] Recently, the pyranonaphthoquinone psychorubrin was first isolated from this extract. [8] Moreover, MFM revealed no toxicity signs in rat models.…”

Section: Introductionmentioning

confidence: 99%

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Anti-inflammatory and antioxidative effects of the methanolic extract of the aerial parts of Mitracarpus frigidus in established animal models

Fabri

Garcia

Florêncio

et al. 2013

Journal of Pharmacy and Pharmacology

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Pentacyclic triterpenoids from Mitracarpus frigidus (Willd. ex Roem. & Schult.) K. Shum: in vitro cytotoxic and leishmanicidal and in vivo anti-inflammatory and antioxidative activities

et al. 2014

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In-vivo laxative and toxicological evaluation and in-vitro antitumour effects of Mitracarpus frigidus aerial parts

Abstract: MFM showed significant antitumour activity for leukaemic cells. Moreover, it presented laxative potential and no in-vivo toxicity.

Cited by 12 publications

References 24 publications

Chromatographic Fingerprint Analysis and Effects of the Medicinal Plant SpeciesMitracarpus frigiduson AdultSchistosoma mansoniWorms

Chromatographic Fingerprint Analysis and Effects of the Medicinal Plant SpeciesMitracarpus frigiduson AdultSchistosoma mansoniWorms

Anti-inflammatory and antioxidative effects of the methanolic extract of the aerial parts of Mitracarpus frigidus in established animal models

Pentacyclic triterpenoids from Mitracarpus frigidus (Willd. ex Roem. & Schult.) K. Shum: in vitro cytotoxic and leishmanicidal and in vivo anti-inflammatory and antioxidative activities

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