Anti-inflammatory and antioxidative effects of the methanolic extract of the aerial parts of <i>Mitracarpus frigidus</i> in established animal models

Fabri, Rodrigo Luiz; Garcia, Roberta Alvim; Florêncio, Jônatas Rodrigues; Pinto, Nícolas de Castro Campos; Oliveira, Luiz Gustavo de; Aguiar, Jair Adriano Kopke de; Ribeiro, Antônia; Scio, Elita

doi:10.1111/jphp.12189

Cited by 17 publications

(8 citation statements)

References 46 publications

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“…Edema inhibitory activity was calculated according to the following formula. Percentage inhibition (%)=(ΔV model -ΔV treated )/ΔV model x100 ( 25 ).…”

Section: Methodsmentioning

confidence: 99%

The anti-inflammatory effects of Yunnan Baiyao are involved in regulation of the phospholipase A2/arachidonic acid metabolites pathways in acute inflammation rat model

Ren

Zhang

Chen

et al. 2017

Molecular Medicine Reports

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The traditional Chinese medicine Yunnan Baiyao (YNB) has been reported to possess anti-inflammatory properties, however its mechanism of action remains unclear. It was previously reported that YNB ameliorated depression of arachidonic acid (AA) levels in a rat model of collagen-induced arthritis. In the current study, the capacity of YNB to ameliorate inflammation was compared in carrageenan-induced and AA-induced acute inflammation of the rat paw with celecoxib and mizolastine, respectively (n=24 per group). The capacity of YNB to affect the phospholipase A2 (PLA2)/AA pathway (using reverse transcription-quantitative polymerase chain reaction) and release of inflammatory lipid mediators (by ELISA) were investigated. Celecoxib ameliorated carrageenan-induced paw edema, and mizolastine ameliorated AA-induced rat paw edema. YNB alleviated paw edema and inhibited inflammatory cell infiltration in the two models. YNB inhibited production of 5-LOX AA metabolite leukotriene B4 (LTB4), and suppressed expression of 5-LOX, cytosolic PLA2 (cPLA2), 5-LOX-activating protein, and LTB4 receptor mRNA in the AA-induced inflammation model (P<0.05). YNB Inhibited the production of the COX-2 AA metabolite prostaglandin E2 (PGE2) and suppressed expression of COX-2, cPLA2, PGE2 mRNA in the carrageenan-induced inflammation mode (P<0.05). Taken together, the data suggest that modulation of COX and LOX pathways in AA metabolism represent a novel anti-inflammatory mechanism of YNB.

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“…Edema inhibitory activity was calculated according to the following formula. Percentage inhibition (%)=(ΔV model -ΔV treated )/ΔV model x100 ( 25 ).…”

Section: Methodsmentioning

confidence: 99%

The anti-inflammatory effects of Yunnan Baiyao are involved in regulation of the phospholipase A2/arachidonic acid metabolites pathways in acute inflammation rat model

Ren

Zhang

Chen

et al. 2017

Molecular Medicine Reports

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“…CG-induced paw edema is a well-established in vivo inflammation model, commonly used to evaluate the anti-edematous effect of natural products [22]. When injected, CG-induced inflammatory edema result in a sequential and integrated actions of several inflammatory mediators.…”

Section: Sammentioning

confidence: 99%

An Ethanolic Extract of Boehmeria caudata Aerial Parts Displays Anti-inflammatory and Anti-tumor Activities

Paiva

Nonato

Ruiz

et al. 2020

PMIO

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The tumor microenvironment presents several therapeutic targets, with inflammation being one of them. In search of new drugs, plants have shown to be an effective source of potent anti-inflammatory and anticancer agents. This study aimed to evaluate the antitumoral and inflammatory activities of Boehmeria caudata aerial parts extract. Bioguided in vitro antiproliferative screening showed that phenanthroquinolizidine obtained from the aerial B. caudata ethanolic extract had a straight relationship with activity. Moreover, the orally administered ethanolic extract reduced Ehrlich solid tumor growth and displayed an anti-inflammatory effect in both evaluated experimental models (carrageenan-induced paw edema and croton oil-induced ear edema). These results suggest that the antitumor activity of the ethanolic extract could be explained by antiproliferative effects associated with anti-inflammatory action.

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“…Two sterile pellets of cotton wool weighing 20±1 mg were implanted subcutaneously, one on each side of the abdomen of the animal under light ether anesthesia aseptically (27,28). Two hours after surgery, topical application of the test drugs (Table II) was initiated on the implanted region, once daily for 7 days.…”

Section: Chronic Inflammation: Cotton Pellet-induced Granulomamentioning

confidence: 99%

Development and Evaluation of Curcumin-loaded Elastic Vesicles as an Effective Topical Anti-inflammatory Formulation

et al. 2014

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Abstract. Curcumin has diverse biological activities including antioxidant and anti-inflammatory activity. However, its clinical use for topical application is limited due to its poor aqueous solubility and thus, minimal cutaneous bioavailability. Elastic vesicles (EVs) of curcumin were prepared to improve its cutaneous bioavailability and to use it for topical anti-inflammatory effect. Ex vivo skin permeation and retention studies were performed to check if incorporation of curcumin into EVs could improve its permeation into and retention in the skin. Evaluation of acute and chronic anti-inflammatory effect was done using xylene-induced acute ear edema in mice and cotton pellet-induced chronic inflammation in rats, respectively. A significant improvement in flux (nine times) across murine skin was observed when aqueous dispersion of curcumin (flux−0.46±0.02 μg/h/cm 2 ) was compared with curcumin-loaded EVs (flux−4.14±0.04 μg/h/cm 2 ). Incorporation of these curcumin-loaded EVs into a hydrophilic ointment base resulted in higher skin retention (51.66%) in contrast to free curcumin ointment (1.64%) and a marketed formulation (VICCO® turmeric skin cream). The developed ointment showed an effect similar (p<0.05) to the marketed diclofenac sodium ointment (Omni-gel®) in suppression of acute inflammation in mouse; a significant inhibition (28.8% versus 3.91% for free curcumin) of cotton pellet-induced chronic inflammation was also observed. Thus, curcumin-loaded EVs incorporated in hydrophilic ointment is a promising topical anti-inflammatory formulation.

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Anti-inflammatory and antioxidative effects of the methanolic extract of the aerial parts of Mitracarpus frigidus in established animal models

Cited by 17 publications

References 46 publications

The anti-inflammatory effects of Yunnan Baiyao are involved in regulation of the phospholipase A2/arachidonic acid metabolites pathways in acute inflammation rat model

The anti-inflammatory effects of Yunnan Baiyao are involved in regulation of the phospholipase A2/arachidonic acid metabolites pathways in acute inflammation rat model

An Ethanolic Extract of Boehmeria caudata Aerial Parts Displays Anti-inflammatory and Anti-tumor Activities

Development and Evaluation of Curcumin-loaded Elastic Vesicles as an Effective Topical Anti-inflammatory Formulation

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