In vivo irreversible albumin-binding near-infrared dye conjugate as a naked-eye and fluorescence dual-mode imaging agent for lymph node tumor metastasis diagnosis

An IR820 Dye–Protein Complex for Second Near‐Infrared Window and Photoacoustic Imaging

“…Studies on IR820 and IR820‐labeled bioconjugates have clearly confirmed its value and prospects in NIR‐I imaging and image‐guided drug or photothermal therapy . An IR820‐based agent was recently designed for naked‐eye and NIR I fluorescence dual‐mode imaging …”

A covalent organic framework as a nanocarrier for synergistic phototherapy and immunotherapy

“…1 Relevant data show that 90% of cancer deaths can be ascribed to the tumor's local recurrence and extensive metastasis. [2][3][4] Along with the growing understanding of how cancer interacts with the immune system, immunotherapies have become a hot topic in the field of cancer therapy, which mainly involve stimulating the body's inherent immune system to attack tumor cells. 5,6 The current immunotherapies include cancer vaccination, [7][8][9] immune checkpoint blockade, 10,11 the chimeric antigen receptor for adoptive T-cell transfer (CAR-T), etc.…”

Cancer-specific calcium nanoregulator suppressing the generation and circulation of circulating tumor cell clusters for enhanced anti-metastasis combinational chemotherapy

“…The foot soles of 4T1 tumor-bearing model were used to evaluate the ability of CPDDs to track CTC clusters from the lymphatic circulation. As mentioned in the previous report, 20 μL PBS containing 4T1 cells (1 × 10 6 cells) were injected into the left hind foot soles of female BALB/c mice 22 . When the tumor reached about 200 mm 3 , 50 μL DiR-loaded PDDs and CPDDs (DiR 1 mg/kg) were intratumorally injected.…”