In vivo investigation of thiomer–polyvinylpyrrolidon nanoparticles using magnetic resonance imaging

Albrecht, Karin; Greindl, Melanie; Deutel, Britta; Kremser, Christian; Wolf, Christian; Talasz, Heribert; Stollenwerk, Maria; Debbage, Paul; Bernkop‐Schnürch, Andreas

doi:10.1002/jps.21969

Cited by 7 publications

(2 citation statements)

References 23 publications

(32 reference statements)

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“…The ability of water-soluble polymers carrying pendant −SH groups to exhibit superior adhesion to mucosal surfaces has previously been demonstrated by Bernkop-Schnürch et al and was related to their ability to form covalent disulfide bridges with mucins. More recently, the same group has reported a successful design of thiolated polymer nanoparticles through the complexation of thiol-carrying macromolecules with complementary polymers in aqueous solutions. , These nanoparticles were found to be mucoadhesive and promising for oral delivery of insulin as demonstrated by in vitro and in vivo experiments.…”

Section: Resultsmentioning

confidence: 99%

Thiolated Mucoadhesive and PEGylated Nonmucoadhesive Organosilica Nanoparticles from 3-Mercaptopropyltrimethoxysilane

Mun²,

2011

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A novel approach has been developed to synthesize thiolated sub-100 nm organosilica nanoparticles from 3-mercaptopropyltrimethoxysilane (MPTS) through its self-condensation in dimethylsulfoxide in contact with atmospheric oxygen. The formation of MPTS nanoparticles proceeds through the condensation of methoxysilane groups and simultaneous disulfide bridging caused by partial oxidation of thiol groups. These nanoparticles showed excellent colloidal stability in dilute aqueous dispersions but underwent further self-assembly into chains and necklaces at higher concentrations. They exhibited very good ability to adhere to ocular mucosal surfaces, which can find applications in drug delivery. The thiolated nanoparticles could also be easily modified through PEGylation resulting in a loss of their mucoadhesive properties.

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Section: Resultsmentioning

confidence: 99%

Thiolated Mucoadhesive and PEGylated Nonmucoadhesive Organosilica Nanoparticles from 3-Mercaptopropyltrimethoxysilane

Mun²,

2011

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“…Due to the application of thiolated polyacrylate the condition did not change. However, when the thiolated polyacrylate was prepared with nanoparticles by the addition of poly(vinylpyrrolidone) a systemic uptake of diethylenetriaminepentaacetic acid gadolinium (III) dihydrogen salt was determined [75].…”

Section: Strategies For Oral Drug Delivery With Lipid Nanoparticlesmentioning

confidence: 99%