In vivo inhibition of E. coli growth by a Ru(II)/Pt(II) supramolecule [(tpy)RuCl(dpp)PtCl2](PF6)

Synthesis, Characterization, Crystal Structure, and Biological Studies of a Cadmium(II) Complex with a Tridentate Ligand 4′-Chloro-2,2′:6′,2′′-Terpyridine

“…The free ligand has considerable activity against Staphylococcus pyogenes , Bacillus anthracis, and Pseudomonas aeruginosa (inhibitory zones ≥20 mm) but has moderate activity against Escherichia coli and Streptococcus aureus (inhibitory zones ≤15 mm) [42, 43]. In comparison with free Cltpy ligand, the complex has more activity against Escherichia coli (more inhibitory zones), but it is less active against Staphylococcus pyogenes , Bacillus anthracis, and Streptococcus aureus , [45]. It is should be noticed that the antibacterial activity of Cltpy ligand is higher than standard antibiotic (gentamicin) against Pseudomonas aeruginosa , Streptococcus pyogenes, and Klebsiella pneumonia .…”

“…In vitro activity test was carried out using the growth inhibitory zone (well method) [42–45]. The potency of components was determined against the three Gram-positive bacteria, Streptococcus pyogenes (RITCC 1940), Staphylococcus aureus (RITCC 1885), and Bacillus anthracis (RITCC 1036), and also against the three Gram-negative bacteria, Klebsiella pneumonia (RITCC 1249), Escherichia coli (RITCC 1330), and Pseudomonas aeruginosa (RITCC 1547).…”

Visible light induced antibacterial properties of a Ru(II)–Pt(II) bimetallic complex

“…20 The overnight cultures were prepared by inoculating frozen E. coli JM109 cells into 15 mL of LB media. The overnight cultures were grown for 12-16 hours at 37 °C.…”

DNA interaction studies of tridentate bridged Ru(II)–Pt(II) mixed-metal supramolecules

“…The metal complexes of type [(tpy)RuCl(BL)PtCl 2 ](PF 6 ) (BL = dpp, dpq, and dpb) have been shown to avidly bind with DNA with a half time (s 1/2 ) of 1-2 min and to occupy binding sites consistent with covalent attachment of the cis-Pt II Cl 2 to DNA [14]. Recently, antimicrobial properties of [(tpy)RuCl(dpp)PtCl 2 ](PF 6 ) have also been reported [18]. However, the use of bidentate bridging ligands leads to a mixture of stereoisomers that are difficult to separate and display differences in reactivity with DNA.…”