In vivo Influence of Nicotine on Human Basal and NSAID-induced Gut Barrier Function

Suenaert, Peter; Bulteel, Veerle; Hond, Elly Den; Geypens, Benny; Monsuur, Fred; Luypaerts, Anja; Ghoos, Yvo; Rutgeerts, Paul

doi:10.1080/00365520310000834

Cited by 23 publications

(38 citation statements)

References 42 publications

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“…This effect might also be caused by the intake of Tac itself, as has been described in rats by others and similar to the effect of nonsteroidal anti-inflammatory drugs (NSAIDs) on human intestinal permeability (21,27) and maybe, the augmented colonic permeability contributed to the enhanced absorption of Tac. However, it has to be mentioned that the observed increment of permeability was in the same range as observed in healthy volunteers after intake of non steroidal anti-inflammatory agents, which have not been reported to augment exposure to Tac.…”

Section: Discussionmentioning

confidence: 92%

“…In addition, total bile acid content of the separate stool collections of each was determined with the a-hydroxysteroid dehydrogenase method. 3 H and 14 C were quantified with the use of b-scintillation as previously described (18,19 Recovery of 51 Cr in urine (with normalization for GFR) collected from start to 6 h after standardized oral intake was used to estimate small intestinal paracellular permeability and the recovery in the consequent urine collection from 6 to 24 h after intake, was used to estimate colonic paracellular permeability (21).…”

Section: Nutrient Assimilation Oro-anal Transit and Mucosal Integritymentioning

confidence: 99%

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Cytochrome P450 3A4 and P-glycoprotein Activity and Assimilation of Tacrolimus in Transplant Patients with Persistent Diarrhea

Lemahieu¹,

Maes²,

Verbeke³

et al. 2005

American Journal of Transplantation

111

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Renal transplant recipients suffering from persistent diarrhea have been repeatedly reported to have increased tacrolimus (Tac) trough levels. This study aimed to explore this phenomenon in detail in 15 renal transplant recipients with diarrhea, whose immunosuppression consisted of corticosteroids, mofetil mycophenolate and Tac. Both hepatic and intestinal CYP3A4 and PGP activity, important determinants of Tac bioavailability, were assessed, together with global CYP activity and investigations for gastrointestinal infection, function and morphology. Global CYP, CYP3A4, PGP and trough/dose levels of Tac were compared with diarrhea-free controls. In addition, a pharmacokinetic study of Tac was performed in 11 patients affected by diarrhea versus 9 controls. As expected, diarrhea was associated with increased Tac trough levels. An even stronger, significant increase of dose-normalized Tac levels was observed between 90 and 360 min after Tac intake. Time to peak concentration and drug half-life, however, were not altered. In addition, a concomitant decrease (±50%) of intestinal PGP activity was noticed in patients with diarrhea. For global CYP, CYP3A4 and hepatic PGP activity no such differences were noted. This pattern was not influenced by the specific cause of diarrhea. These data strongly suggest that persistent diarrhea is associated with an increased oral bioavailability of Tac.

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Section: Discussionmentioning

confidence: 92%

Section: Nutrient Assimilation Oro-anal Transit and Mucosal Integritymentioning

confidence: 99%

Cytochrome P450 3A4 and P-glycoprotein Activity and Assimilation of Tacrolimus in Transplant Patients with Persistent Diarrhea

Lemahieu¹,

Maes²,

Verbeke³

et al. 2005

American Journal of Transplantation

111

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“…In addition, this index can also be used in prediction of the recurrence of the disease. The multi-parameter regression analysis of 47 cases of intensive care patients [9,10] demonstrated that the intestinal mucosal permeability is the only index which can predict the development of multi-organ function failure syndrome in critical patients.…”

Section: Discussionmentioning

confidence: 99%

Soluble intercellular adhesion molecule-1, D-lactate and diamine oxidase in patients with inflammatory bowel disease

Song¹,

Lv²,

Zhang³

et al. 2009

WJG

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AIM:To study the levels of serum soluble intercellular adhesion molecule-1 (sICAM-1), plasma D-lactate and diamine oxidase (DAO) in patients with inflammatory bowel disease (IBD), and the potential clinical significance. METHODS:Sixty-nine patients with IBD and 30 healthy controls were included in this study. The concentration of sICAM-1 was detected with enzyme-linked immunosorbent assay, the level of D-lactate and DAO was measured by spectroscopic analysis, and the number of white blood cells (WBC) was determined by routine procedure. RESULTS:The levels of sICAM-l, DAO, and WBC in IBD patients were significantly higher than those in the control group (P < 0.01). sICAM-l in IBD patients was found to be closely related to the levels of DAO and D-lactate (212.94 ± 69.89 vs 6.35 ± 2.35, P = 0.000), DAO 212.94 ± 69.89 vs 8.65 ± 3.54, P = 0.000) and WBC (212.94 ± 69.89 vs 7.40 ± 2.61, P = 0.000), but no significant difference was observed between patients with ulcerative colitis and patients with Crohn's disease. The post-treatment levels of sICAM-l, D-lactate and WBC were significantly lower than before treatment (sICAM-l 206.57 ± 79.21 vs 146.21 ± 64.43, P = 0.000), (D-lactate 1.46 ± 0.94 vs 0.52 ± 0.32, P = 0.000) and (WBC 7.24 ± 0.2.33 vs 5.21 ± 3.21, P = 0.000).CONCLUSION: sICAM-1, D-lactate and DAO are closely related to the specific conditions of IBD, and thus could be used as a major diagnostic index.

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“…8,9 As a result of bacterial localization, the colon is possibly the main source of bacterial endotoxin translocation, and the resulting endotoxinaemia leads to inflammatory reactions. Endotoxin core antibodies (EndoCAb) are able to neutralize endotoxins, 10 and a decrease in the plasma concentration of EndoCAb may indicate an organism's response to endotoxinaemia.…”

Section: J-p Braun S Buhner M Kastrup Et Al Gut Barrier Function Amentioning

confidence: 99%

“…18 -20 Sucralose has been used as a marker of intestinal and colonic permeability. 9 The determination of sucralose from late-collected urine (5 -24 h after administration) describes colonic absorption. 21 Results were evaluated upon completion of patient observations.…”

Section: Protocolmentioning

confidence: 99%

Barrier Function of the Gut and Multiple Organ Dysfunction after Cardiac Surgery

Bühner

Kastrup

et al. 2007

J Int Med Res

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72We studied the influence of sequential involvement of the gastrointestinal (GI) tract on the development of multiple organ dysfunction (MOD) after cardiopulmonary bypass (CPB). One hundred and forty-six patients undergoing elective cardiac surgery were included in this prospective observational study. Standardized oral inert-sugar tests (sucrose, lactulose, mannitol, sucralose) were performed before and after CPB in different patients. Enzyme-linked immunosorbent assay of plasma levels of endotoxin core antibodies (EndoCAb) were performed peri-operatively. The functional mucosal surface was calculated from the amount of mannitol absorbed from the GI tract. Lower urine concentrations of absorbed mannitol were observed preoperatively in patients developing MOD. In binary logistic regression this was an independent parameter. Decreased plasma concentrations of EndoCAb after surgery were seen in every patient, but were more significant in patients developing MOD. A reduced pre-operative functional mucosal surface may predict the early occurrence of MOD after surgery.

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In vivo Influence of Nicotine on Human Basal and NSAID-induced Gut Barrier Function

Cited by 23 publications

References 42 publications

Cytochrome P450 3A4 and P-glycoprotein Activity and Assimilation of Tacrolimus in Transplant Patients with Persistent Diarrhea

Cytochrome P450 3A4 and P-glycoprotein Activity and Assimilation of Tacrolimus in Transplant Patients with Persistent Diarrhea

Soluble intercellular adhesion molecule-1, D-lactate and diamine oxidase in patients with inflammatory bowel disease

Barrier Function of the Gut and Multiple Organ Dysfunction after Cardiac Surgery

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