In vivo-in vitro Correlations with a Commercial Dissolution Simulator I: Methenamine, Nitrofurantoin, and Chlorothiazide

Yau, Martin K.T.; Meyer, Marvin C.

doi:10.1002/jps.2600700913

Cited by 11 publications

(1 citation statement)

References 10 publications

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“…Dissolution‐rate‐limited absorption (Aiache et al ., 1989; Davi et al ., 1989; Hussein & Friedman, 1990; Mojaverian et al ., 1992; Caramella et al ., 1993; Fassihi & Rislel, 1993; Harrison et al ., 1993; Humbert et al ., 1994) in particular has been emphasized in the literature and has shown high in vitro – in vivo correlation (IVIVC). Far fewer studies have emphasized permeation‐rate‐limited absorption in some cases of immediate‐release products (Strum et al ., 1978; Sylvestri & Uda, 1979; Yau & Meyer, 1981; Welling et al ., 1982; Yau & Meyer, 1983; El‐Yazigi & Sawchuk, 1985; Chung & Shim, 1987; Mayer et al ., 1992) where, as this analysis predicts, IVIVC is low. Amidon et al .…”

Section: Introductionmentioning

confidence: 99%

The effect of soybean oil refuse powder used as vehicle on the absorption of oxolinic acid in chickens under fasting and nonfasting conditions and the correlation with in vitro dissolution

Hamamoto

Koike

Machida

2001

Vet Pharm & Therapeutics

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The effect of soybean oil refuse powder (SOR) when used as a vehicle on the absorption of oxolinic acid (OXA) powder in chicken, the dissolution profile of OXA and the correlation between in vivo and in vitro study were examined. To examine in vivo bioavailability, chickens fed or fasted were studied using a 2 x 2 crossover design. The OXA was administered OXA or OXA-SOR (1 : 9) mixture 20 mg OXA/kg. In vitro dissolution rates for OXA and OXA-SOR were measured using the paddle (PD) and the rotatory dialysis cell dissolution (PTSW) methods. Maximum plasma concentration (Cmax) and area under the curve (AUC) were significantly increased by the addition of SOR to OXA. Differences between OXA and OXA-SOR were more remarkable under fasted as compared with fed condition. In vitro dissolution rates of OXA-SOR pH 1.2, 6.5 and 7.2 as determined by the PD and the PTSW methods were increased in the presence of SOR vehicle. Differences between OXA and OXA-SOR in vitro dissolution rates were greater than in vivo bioavailability. Correlation between in vitro release (%) and in vivo absorption (%) showed good linearity (gamma=0.8805-0.9999).

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Section: Introductionmentioning

confidence: 99%

The effect of soybean oil refuse powder used as vehicle on the absorption of oxolinic acid in chickens under fasting and nonfasting conditions and the correlation with in vitro dissolution

Hamamoto

Koike

Machida

2001

Vet Pharm & Therapeutics

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Selected Aliphatic and Aromatic Nitrogen Compounds

Ziegler‐Skylakakis

2023

Patty's Toxicology

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This is an update of a previous chapter. It presents an evaluation of the toxicological potential of a number of aliphatic and aromatic nitrogen compounds, with information on their use, production, and exposure scenarios. These compounds were originally selected on the basis of their use in industry. In general, there has been little new information published in the literature that has significantly altered the previous profile of each compound. The three‐membered ring compounds discussed are ethyleneimine, propylenenimine, and triethylenemelamine. They are alkylating agents and have toxicological properties similar to nitrogen mustards. Six nitrogen mustards and their hydrochlorides are discussed as a group of chemicals. Furthermore, data on representatives of five‐membered ring nitrogen compounds (pyrrolidine, N ‐methyl‐2‐pyrrolidone) and of six‐membered ring compounds (piperidine, piperazine, morpholine, and hexamethylenetetramine) are included. Captan, captafol, and folpet—three N ‐sulfenyl phthalimide fungicides—and benomyl, carbendazim, and thiophanate‐methyl—benzimidazole fungicides—are evaluated as separate groups. Data on 1‐ H ‐benzotriazol are also included in this chapter. The subchapter of each compound or group of compounds includes the physical and chemical properties, information as to use and production, data on the toxicological potential, and standards, regulations, or guidelines of exposure. In addition, data on the environmental impact of each compound or group of compounds are presented and evaluated.

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Aliphatic and Aromatic Nitrogen Compounds

Trochimowicz¹,

Kennedy²,

Krivanek³

2001

Patty's Toxicology

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This chapter covers both aliphatic and aromatic compounds that contain one or more nitrogen atoms in their structures. Only a small number of the nitrogen‐containing compounds that could be considered will be reviewed here based mainly on their uses in industry. Three‐membered rings discussed are ethyleneimine, propyleneimine, and one polyfunctional derivative, triethylenemelamine. Toxicologists, chemists, and biologists have always been interested in ethylenimine and its derivatives because they are reactive, are useful at relatively low doses, and are moderately to highly toxic. Ethylenimines are classic alkylating agents and have toxicological effects similar to nitrogen mustards. Monofunctional derivatives of ethylenimine are less potent in producing the characteristic toxicity of the group than the derivatives that have two or more ethylenimine groups. Finally, polymers of ethylenimine and its derivatives have shown a relatively low order of toxicity. Six simple nitrogen mustards (β‐chloroethylamines) are also covered in this chapter. They are all tertiary amines in which the halogen atom and the amine portion have reactivities similar to the alkyl halides and alkyl amines. They have no significant industrial uses in the United States, but they are used in medicine as “antineoplastic agents” and in treating some nonmalignant diseases. Representative nitrogen‐containing chemicals that have five‐membered rings (pyrrolidine, NMP) and six‐membered rings (piperidine, piperazine, morpholine, and HMTA) are also discussed in this chapter in some detail.

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In vivo-in vitro Correlations with a Commercial Dissolution Simulator I: Methenamine, Nitrofurantoin, and Chlorothiazide

Cited by 11 publications

References 10 publications

The effect of soybean oil refuse powder used as vehicle on the absorption of oxolinic acid in chickens under fasting and nonfasting conditions and the correlation with in vitro dissolution

The effect of soybean oil refuse powder used as vehicle on the absorption of oxolinic acid in chickens under fasting and nonfasting conditions and the correlation with in vitro dissolution

Selected Aliphatic and Aromatic Nitrogen Compounds

Aliphatic and Aromatic Nitrogen Compounds

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