In vivo immunosuppression by synthetic pyrethroid (cypermethrin) pesticide in mice and goats

Tamang, Rakesh; Jha, G.J.; Gupta, M. K.; Chauhan, Himanshu; Tiwary, B.K.

doi:10.1016/0165-2427(88)90116-x

Cited by 38 publications

(26 citation statements)

References 11 publications

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“…In the present study, elevated serum alkaline phosphatase was seen. The findings are in agreement with Tamang et al (1988). Elevated levels of this enzyme are associated with an increase in osteoblastic activity and damage to liver (Falconer and King, 1970).…”

Section: Body Weight and Blood Biochemistrysupporting

confidence: 80%

“…Control chicks received starter mash without any pesticide. An earlier experiment (Tamang et al, 1988) carried out in our laboratory indicated 20-25 ppm as a minimum toxic dose (MTD) of monocrotophos and endosulfan in mice. One-tenth of this MTD was selected as the dose for chronic toxicity in chicks.…”

Section: Pesticide Toxicity and Bone Health Of Chickens 365mentioning

confidence: 99%

“…One-tenth of this MTD was selected as the dose for chronic toxicity in chicks. The MTD of cypermethrin was found to be 200 ppm in mice (Tamang et al, 1988) and one-tenth of this dose was used for evaluating chronic toxicity of fenvalerate in chicks. Other criteria for selection of the dose of endosulfan and monocrotophos were our laboratory experience with toxicological investigation of malathion/organophosphate Kushwah, 1998, 2000), endosulfan/chlorinated hydrocarbon (Pushpanjali et al, 1999;Pushpanjali et al, unpublished data), and available literature (Smith, 1993;Singh et al, 2001).…”

Section: Pesticide Toxicity and Bone Health Of Chickens 365mentioning

confidence: 99%

“…India uses approximately 85,000 tons of pesticides per annum and an 8% increase in pesticide use is expected every year. Currently 400 members of three groups of pesticides (organochlorates, organophosphates and synthetic pyrethroids) are being used in India (Tamang et al, 1988). About 40% of these are organochlorates (such as endosulfan, dicofol, aldrin, dieldrin, lindane, isodrin, heptachlor).…”

Section: Introductionmentioning

confidence: 99%

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Pathophysiological Effects of Chronic Toxicity with Synthetic Pyrethroid, Organophosphate and Chlorinated Pesticides on Bone Health of Broiler Chicks

et al. 2004

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This experiment evaluated effects following chronic toxicity with 20 ppm fenvalerate (synthetic pyrethroid), 2 ppm monocrotophos (organophosphate) and 2 ppm endosulfan (chlorinated hydrocarbon) on bone health of broiler chicks. A total of 120 chicks were divided equally into 4 groups and were fed poultry mash without (control) or mixed with different pesticides for 8 weeks. Body mass, serum calcium and phosphorus levels were unaffected due to pesticides treatment. However, an increase ( p < 0.01) in serum alkaline phosphatase activity was noted and serum total protein decreased ( p < 0.01) in all treated groups. Roentogenography revealed destructive changes in the upper part of the femur in the monocrotophos group. Endosulfan intoxicated chicks had increased numbers of trabeculae in the medullary cavity. Microscopic alterations of the costochondral junction in intoxicated chicks were similar. The zones of proliferating, maturing and degenerating, and calcifying cartilage cells were reduced in width and the metaphysis in treated birds showed a reduced number of cartilage cells and thinner trabeculae. Due to toxicity, the capillary scaffolding of the degenerating cartilage cells was reduced and a larger number of transverse trabeculae could be seen in the metaphysis. Appositional bone growth studied by the tetracyclicline labeling technique indicated decreased active osteons.

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Section: Body Weight and Blood Biochemistrysupporting

confidence: 80%

Section: Pesticide Toxicity and Bone Health Of Chickens 365mentioning

confidence: 99%

Section: Pesticide Toxicity and Bone Health Of Chickens 365mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Pathophysiological Effects of Chronic Toxicity with Synthetic Pyrethroid, Organophosphate and Chlorinated Pesticides on Bone Health of Broiler Chicks

et al. 2004

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“…Several reports have been indicated the inducible stress-like symptoms of pyrethroid insecticides in experimental animals [12][13][14]. Moreover, treatment of different animal models with type II pyrethroids such as deltamethrin, cypermethrin, fenvalerate and supercypermethrin forte, showed many immunosuppressive effects on humoral and cell-mediated immune response [15][16][17][18]. Furthermore, some pyrethroid insecticides have been reported to cause spleen, thymus and lymph node damage as well as mutagenesis and carcinogenesis [19,20].…”

Section: Introductionmentioning

confidence: 99%

Evaluation of the Immunotoxic Effects of Sub-Chronic Doses of Lambda-Cyhalothrin in Murine Model

Ibrahim¹

2016

MOJI

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Lambda-cyhalothrin (LCT) is belonging to type II pyrethroid insecticides and utilized predominantly in Egypt to control a wide range of ectoparasites, including flies, mosquitoes, and cockroaches. Previous studies detected obvious genotoxicity and cytotoxicity of LCT. The current study was done to evaluate the immunological alterations on the levels of humoral and cellular immune responses after exposure to different doses (5, 1, 0.2mg/kg/day) of LCT in rat model. The current data displayed that LCT at dose 5mg/kg suppressed the total serum immunoglobulin concentration, hemagglutination titer, quantitative hemolysis of SRBCs (QHS), the phagocytic function of peritoneal macrophages and blood neutrophils. Moreover, 5mg/kg of LCT decreased the delayed-type hypersensitivity response, the proliferative response of the blood mononuclear cells, induced blood mononuclear cells death and reduced the percentage of CD4+ and CD8 + blood mononuclear cells without affecting CD4/CD8 ratio significantly. LCT at dose 1mg/kg inhibited the total serum immunoglobulin, QHS, the proliferative capacity of blood mononuclear cells, the phagocytic function of peritoneal macrophages and blood neutrophils. No significant differences were observed in all examined parameters in animals exposed to 0.2mg/kg of LCT.In conclusion, LCT exposure induced-immunotoxicity in a rat model at doses 5 and 1mg/kg, while 0.2mg/kg has no adverse effect on the examined immune parameters.Keywords: Lambda-cyhalothrin Evaluation of the Immunotoxic Effects of Sub-Chronic Doses of Lambda-Cyhalothrin in Murine Model 2/8Copyright: ©2016 Ibrahim dose-dependent immunological alterations resulted by LCT. In the current study, doses of 5, 1 and 0.2 mg/kg of LCT were orally administrated to male rats. The oral LD50 value of LCT was estimated to be 79 mg/kg in male rats [22]. The selected doses of LCT were at least 15 times smaller than those recorded for LD50 in male rats and therefore adequate for the search for an immunological no-observed-adverse-effect level (NOAEL). Moreover, recent study reported that 0.6 mg/kg of LCT elicited significant alterations in the level of malondialdehyde (MDA), nitric oxide, pro-inflammatory cytokines and up-regulated NF-κB/ p65 in a rat model [23]. Hence, 0.2 mg/kg of LCT, which considered three times lower than the dose that used in the previous study, could be especially convenient for the immunological NOAEL. Keeping this in view, the main goal of this study was to evaluate the immunotoxic effects of the selected sub-chronic doses of LCT in a rat model. The current study was extended to examine the suitable dose for the assessment of the NOAEL among the selected doses. Material and methods Chemicals AnimalsMale albino Wistar rats (weighting approximately 210-250 g) were obtained from the Egyptian Organization for Serology and Vaccination, Ministry of Health, Cairo, Egypt. For the preparation of complement which utilized in quantitative hemolysis of sheep red blood cells (SRBCs) assay, female guinea pigs (240g) were used. Al...

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Suppression of cellular immune responses in BALB/c mice following oral exposure to permethrin

Blaylock

Abdel-Nasser

McCarty

et al. 1995

Bull. Environ. Contam. Toxicol.

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In vivo immunosuppression by synthetic pyrethroid (cypermethrin) pesticide in mice and goats

Cited by 38 publications

References 11 publications

Pathophysiological Effects of Chronic Toxicity with Synthetic Pyrethroid, Organophosphate and Chlorinated Pesticides on Bone Health of Broiler Chicks

Pathophysiological Effects of Chronic Toxicity with Synthetic Pyrethroid, Organophosphate and Chlorinated Pesticides on Bone Health of Broiler Chicks

Evaluation of the Immunotoxic Effects of Sub-Chronic Doses of Lambda-Cyhalothrin in Murine Model

Suppression of cellular immune responses in BALB/c mice following oral exposure to permethrin

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