In-vivo hypoglycemic and hypolipidemic properties of Tagetes lucida alcoholic extract in streptozotocin-induced hyperglycemic Wistar albino rats

Abdel-Haleem, Samah A.; Ibrahim, Abeer Y.; Fouad, Rasha; Shaffie, Nermeen; Hendawy, Saber F.; Omer, Elsayed A.

doi:10.1016/j.aoas.2017.11.005

Cited by 17 publications

(6 citation statements)

References 46 publications

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“…The hypoglycemic effect observed in both DM- Z and CH-DM- Z groups can also be attributed to the phytochemical content in Z. album extract. Similarly, Abdel-Haleem et al (2017) demonstrated that glucose level in STZ-induced hyperglycemic Wistar albino rats underwent a significant reduction after administration of Tagetes lucida alcoholic extract. Therefore, supplementation of aqueous extract of Monascus fermented rice in STZ and high-cholesterol-diet fed rats for 30 days showed significant reduction of fasting blood glucose level (Rajasekaran et al , 2009).…”

Section: Discussionmentioning

confidence: 84%

Zygophyllum albumaqueous extract reduces glycemia and ameliorates lipid profile and oxidative damage in hypercholesterolemic-diabetic rats

Bahlil

Krouf

Taleb-Dida

2019

NFS

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Purpose This paper aims to study the effects of Zygophyllum album (Za) (Z. album) in hypercholesterolemic-diabetic rats. Design/methodology/approach Male Wistar rats (n = 36) weighing 200 ± 10 g, consumed an experimental diet containing 20 per cent casein were divided into three groups (n = 12). The first group consumed the diet enriched with 1 per cent cholesterol (CH), the second group is rendered diabetic by intraperitoneal injection of streptozotocin (STZ) (35 mg/kg body weight) (D) (DM). The third group is hypercholesterolemic and STZ-induced diabetic (CH-DM); each group was subdivided into two groups (n = 6), non-treated groups (CH, DM and CH-DM) and treated groups supplemented with 1 per cent Z. album lyophilized aqueous extract (CH-Z, DM-Z and CH-DM-Z). Findings In CH-DM group, Z. album decreases glycemia (−15 per cent) and inversely increases insulinemia (+28 per cent) and Homeostasis Model Assessment of Insulin Resistance (+19 per cent). In liver, total cholesterol (TC) and triacyglycerols (TAG) levels were reduced by −57 per cent and −29 per cent, respectively. In plasma, TC concentration was increased by +20 per cent, whereas those of TAG level were lowered by −56 per cent. Lecithin cholesterol acyl transferase and paraoxonase 1 activities were raised by +45 and +59 per cent, respectively. Inversely, thiobarbituric acid reactive substance levels were lowered significantly in liver, heart, kidney and adipose tissue (p < 0.05). Superoxide dismutase activity was enhanced in liver (+54 per cent), heart (+36 per cent), kidney (+45 per cent) and adipose tissue (59 per cent). Liver glutathione peroxidase (GSH-Px) activity was enhanced by +38 per cent and heart activities of GSH-Px, and glutathione reductase (GSSH-Red) were increased by +25 and +18 per cent. In kidney, GSH-Px activity was reduced by −26 per cent; in reverse, GSSH-Red activity was increased by +14 per cent. In adipose tissue, GSH-Px and GSSH-Red activities were augmented by +35 and +15 per cent. Originality/value These results suggest that Z. album aqueous extract has antihyperglycemic and antihyperlipemic actions. Also, Z. album protects against tissue oxidative damage; therefore, it can help to prevent cardiovascular complications of diabetes combined with hypercholesterolemia.

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Section: Discussionmentioning

confidence: 84%

Zygophyllum albumaqueous extract reduces glycemia and ameliorates lipid profile and oxidative damage in hypercholesterolemic-diabetic rats

Bahlil

Krouf

Taleb-Dida

2019

NFS

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“…Several chemical hypoglycemic drugs are used, including insulin, sulfonylureas, metformin, Na+-glucose exchanger inhibitors, meglitinides, GLP-1 agonists, dipeptidyl peptidase-4 inhibitors, insulin analogs and α -glucosidase inhibitors. These drugs have, nevertheless, side effects warranting the search for new hypoglycemic natural compounds with less side effects [ 5 ]. Reproductive dysfunction and male testicular damage are consequences of DM in both humans and animals.…”

Section: Introductionmentioning

confidence: 99%

Chemical Profile of Launaea nudicaulis Ethanolic Extract and Its Antidiabetic Effect in Streptozotocin-Induced Rats

et al. 2021

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Launaea nudicaulis is used in folk medicine worldwide to treat several diseases. The present study aimed to assess the antidiabetic activity of L. nudicaulis ethanolic extract and its effect on diabetic complications in streptozotocin-induced hyperglycemic rats. The extract was orally administrated at 250 and 500 mg/kg/day for 5-weeks and compared to glibenclamide as a reference drug at a dose of 5 mg/kg/day. Administration of the extract exhibited a potential hypoglycemic effect manifested by a significant depletion of serum blood glucose concurrent with a significant elevation in serum insulin secretion. After 5-weeks, extract at 250 and 500 mg/kg/day decreased blood glucose levels by about 53.8 and 68.1%, respectively, compared to the initial values (p ≤ 0.05). The extract at the two dosages prevented weight loss of rats from the 2nd week till the end of the experiment, compared to diabetic control rats. The extract further exhibited marked improvement in diabetic complications including liver, kidney and testis performance, oxidative stress, and relative weight of vital organs, with respect to diabetic control. Histopathological examinations confirmed the previous biochemical analysis, where the extract showed a protective effect on the pancreas, liver, kidney, and testis that degenerated in diabetic control rats. To characterize extract composition, UPLC-ESI–qTOF-MS identified 85 chromatographic peaks belonging to flavonoids, phenolics, acyl glycerols, nitrogenous compounds, and fatty acids, with four novel phenolics reported. The potential anti-diabetic effect warrants its inclusion in further studies and or isolation of the main bioactive agent(s).

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“…Within 24 hours of the last dose, blood was collected from rats on an overnight fasting basis from each group by retro-orbital site, to estimate lipid profiles, glycolated heamoglobin, hematological, liver function, kidney function, and enzyme oxidative parameters. Finally, at the end of the twenty-second day, the animals are dissected to isolate the vital organs (pancreas, liver, and kidney) for histopathological examination [17].…”

Section: Treatment Schedule and Estimation Of Fasting Blood Glucose L...mentioning

confidence: 99%

Untitled

2023

J. Med. Chem. Sci.

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Rourea minor is a medicinal plant with anti-diabetic properties, and it can be found in South and North Asian countries. The study design involves the preparation of an ethanol Rourea minor stem extract; investigation of its oral glucose tolerance test, body weight, blood glucose, hematological, lipid profile, liver and kidney parameters, enzymatic oxidative parameters, and histopathology of the liver, kidney, and pancreas. Streptozotocin (55 mg/kg b.w) was given intraperitoneally in a single dose and was used to cause diabetes in male Wistar rats. Diabetic rats were treated with 200 and 400 mg/kg body weight of Rourea minor stems ethanol extract, and standard Glibenclamide (5 mg/kg b.w/day) for a period of 21 days. Oral administration of Rourea minor stems ethanol extract did not exhibit toxicity and death at a dose of 2000 mg/kg b.w. Rourea minor stems ethanol extract treated diabetic rats significantly (P<0.0001) reduced elevated blood glucose, glycolated heamoglobin, creatinine, urea, low-density lipoproteins, very low-density lipoproteins, alkaline phosphatase, serum glutamic pyruvic transaminase, serum glutamic-oxaloacetic transaminase, glutathione, glutathione reductase, glutathione S-transferase, and malondialdehyde levels when compared with diabetic control rats. The body weight, protein, albumin, hemoglobin, red blood cells, white blood cells, and high-density lipoprotein levels were significantly (P<0.0001) increased in diabetic rats treated with Rourea minor stems ethanol extract, as compared with diabetic control rats. The present study results confirm that Rourea minor stems ethanol extract possesses significant anti-diabetic and anti-oxidant activities in diabetic conditions.

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In-vivo hypoglycemic and hypolipidemic properties of Tagetes lucida alcoholic extract in streptozotocin-induced hyperglycemic Wistar albino rats

Cited by 17 publications

References 46 publications

Zygophyllum albumaqueous extract reduces glycemia and ameliorates lipid profile and oxidative damage in hypercholesterolemic-diabetic rats

Zygophyllum albumaqueous extract reduces glycemia and ameliorates lipid profile and oxidative damage in hypercholesterolemic-diabetic rats

Chemical Profile of Launaea nudicaulis Ethanolic Extract and Its Antidiabetic Effect in Streptozotocin-Induced Rats

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