In vivo high-resolution magnetic resonance elastography of the uterine corpus and cervix

Jiang, Xiaohui; Asbach, Patrick; Streitberger, Kaspar-Josche; Thomas, Anke; Hamm, Bernd; Braun, Jürgen; Sack, Ingolf; Guo, Jing

doi:10.1007/s00330-014-3305-8

Cited by 46 publications

(30 citation statements)

References 35 publications

(41 reference statements)

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“…3D MRE of the uterus in healthy female volunteers showed that the uterine corpus had a higher elasticity but similar viscosity compared to cervix [106]. In this study, it was also found that stiffness of both endometrium and myometrium decreased during the menstrual cycle.…”

Section: Mre Of Uterussupporting

confidence: 65%

Magnetic resonance elastography of abdomen

Venkatesh

Ehman

2014

Abdom Imaging

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Many diseases cause substantial changes in the mechanical properties of tissue and this provides motivation for developing methods to non-invasively assess the stiffness of tissue using imaging technology. Magnetic resonance elastography (MRE) has emerged as a versatile MRI-based technique, based on direct visualization of propagating shear waves in the tissues. The most established clinical application of MRE in the abdomen is in chronic liver disease. MRE is currently regarded as the most accurate non-invasive technique for detection and staging of liver fibrosis. Increasing experience and ongoing research is leading to exploration of applications in other abdominal organs. In this review article, the current use of MRE in liver disease and the potential future applications of this technology in other parts of the abdomen are surveyed.

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Section: Mre Of Uterussupporting

confidence: 65%

Magnetic resonance elastography of abdomen

Venkatesh

Ehman

2014

Abdom Imaging

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“…Jiang et al [257] employed 3D multifrequency MRE to the uterus and analyzed the viscoelasticity of the uterine tissue in healthy volunteers. They observed that the uterine corpus has higher elasticity, but similar viscosity compared with the cervix, in terms of complex shear modulus (uterine corpus = 2.58 ± 0.52 kPa vs. cervix = 2.00 ± 0.34 kPa).…”

Section: Labor Disordersmentioning

confidence: 99%

Why Are Viscosity and Nonlinearity Bound to Make an Impact in Clinical Elastographic Diagnosis?

Rus

Faris

Torres

et al. 2020

Sensors

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The adoption of multiscale approaches by the biomechanical community has caused a major improvement in quality in the mechanical characterization of soft tissues. The recent developments in elastography techniques are enabling in vivo and non-invasive quantification of tissues’ mechanical properties. Elastic changes in a tissue are associated with a broad spectrum of pathologies, which stems from the tissue microstructure, histology and biochemistry. This knowledge is combined with research evidence to provide a powerful diagnostic range of highly prevalent pathologies, from birth and labor disorders (prematurity, induction failures, etc.), to solid tumors (e.g., prostate, cervix, breast, melanoma) and liver fibrosis, just to name a few. This review aims to elucidate the potential of viscous and nonlinear elastic parameters as conceivable diagnostic mechanical biomarkers. First, by providing an insight into the classic role of soft tissue microstructure in linear elasticity; secondly, by understanding how viscosity and nonlinearity could enhance the current diagnosis in elastography; and finally, by compounding preliminary investigations of those elastography parameters within different technologies. In conclusion, evidence of the diagnostic capability of elastic parameters beyond linear stiffness is gaining momentum as a result of the technological and imaging developments in the field of biomechanics.

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“…Miklos et al in a study performed on 24 patients under small compressions, and a range of frequencies from 0.1 to 100 Hz [ 27 ] concluded that normal cervical tissue exhibited values of complex modulus over the same range. Finally, Jiang et al applied 3D multifrequency MR elastography (3DMMRE) to study the viscoelasticity of the uterus and cervix, showing sensitivity to structural and functional changes of the endometrium and myometrium during the menstrual cycle [ 28 ].…”

Section: Introductionmentioning

confidence: 99%

Performance Study of a Torsional Wave Sensor and Cervical Tissue Characterization

Callejas

Gómez

Melchor

et al. 2017

Sensors

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A novel torsional wave sensor designed to characterize mechanical properties of soft tissues is presented in this work. Elastography is a widely used technique since the 1990s to map tissue stiffness. Moreover, quantitative elastography uses the velocity of shear waves to achieve the shear stiffness. This technique exhibits significant limitations caused by the difficulty of the separation between longitudinal and shear waves and the pressure applied while measuring. To overcome these drawbacks, the proposed torsional wave sensor can isolate a pure shear wave, avoiding the possibility of multiple wave interference. It comprises a rotational actuator disk and a piezoceramic receiver ring circumferentially aligned. Both allow the transmission of shear waves that interact with the tissue before being received. Experimental tests are performed using tissue mimicking phantoms and cervical tissues. One contribution is a sensor sensitivity study that has been conducted to evaluate the robustness of the new proposed torsional wave elastography (TWE) technique. The variables object of the study are both the applied pressure and the angle of incidence sensor–phantom. The other contribution consists of a cervical tissue characterization. To this end, three rheological models have fit the experimental data and a static independent testing method has been performed. The proposed methodology permits the reconstruction of the mechanical constants from the propagated shear wave, providing a proof of principle and warranting further studies to confirm the validity of the results.

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In vivo high-resolution magnetic resonance elastography of the uterine corpus and cervix

Abstract: MR elastography provided for the first time spatially resolved viscoelasticity maps of uterus. Uterine corpus had a higher elasticity, but similar viscosity compared with cervix. The stiffness of both endometrium and myometrium decreases during the menstrual cycle.

Cited by 46 publications

References 35 publications

Magnetic resonance elastography of abdomen

Magnetic resonance elastography of abdomen

Why Are Viscosity and Nonlinearity Bound to Make an Impact in Clinical Elastographic Diagnosis?

Performance Study of a Torsional Wave Sensor and Cervical Tissue Characterization

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