In vivo expression of a new hepatitis B virus protein encoded by a spliced RNA

Soussan, Patrick Ben; Garreau, Florianne; Zylberberg, Hervé; Ferray, Cyrille; Bréchot, Christian; Kremsdorf, Dina

doi:10.1172/jci8098

Cited by 138 publications

(126 citation statements)

References 23 publications

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“…A new HBV protein, referred to as HBSP, is encoded by one of the spliced RNAs of HBV (Soussan et al, 2000) (Figure 6). This protein is translated from the AUG of polymerase and because of splicing, is endowed in its C-terminal moiety with a sequence that differs from that of other viral proteins.…”

Section: Hbv-related Hcc D Kremsdorf Et Almentioning

confidence: 99%

“…In vivo, HBSP protein has been detected in liver biopsy specimens from patients with active chronic hepatitis. In addition, antibodies directed against this protein have been found in the serum of approximately 45% of patients with chronic hepatitis (Soussan et al, 2000(Soussan et al, , 2003. In vitro, HBSP expression induces apoptosis without cell-cycle block (Soussan et al, 2000).…”

Section: Hbv-related Hcc D Kremsdorf Et Almentioning

confidence: 99%

“…In addition, antibodies directed against this protein have been found in the serum of approximately 45% of patients with chronic hepatitis (Soussan et al, 2000(Soussan et al, , 2003. In vitro, HBSP expression induces apoptosis without cell-cycle block (Soussan et al, 2000). More recently, HBSP protein expression was correlated with viral replication and with the onset of hepatic fibrosis (Soussan et al, 2003).…”

Section: Hbv-related Hcc D Kremsdorf Et Almentioning

confidence: 99%

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Hepatitis B virus-related hepatocellular carcinoma: paradigms for viral-related human carcinogenesis

et al. 2006

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As discussed in detail in other chapters of this review, chronic hepatitis B (HBV) infection is a major risk factor for hepatocellular carcinoma (HCC). Most HCCs complicate the evolution of an active or inactive cirrhosis. However, some tumors occur on livers with minimal histological changes; the prevalence of such cases varies from one geographical region to the other, being much higher in the southern half of Africa (around 40% of HCCs) than in Asia, America and Europe, where at least 90% of HCCs are associated with the cirrhosis. This heterogeneity is probably a reflection of different environmental and genetic factors. This review will summarize the current knowledge on the mechanisms involved in HBVrelated liver carcinogenesis. It will show in particular how viruses can be viewed as tools to discover and dissect new cellular pathways involved in cancer development and emphasize the potential synergistic effects between HBV and hepatitis C virus, as well as between viral infections and other environmental factors, such as alcohol.

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Section: Hbv-related Hcc D Kremsdorf Et Almentioning

confidence: 99%

Section: Hbv-related Hcc D Kremsdorf Et Almentioning

confidence: 99%

Section: Hbv-related Hcc D Kremsdorf Et Almentioning

confidence: 99%

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Hepatitis B virus-related hepatocellular carcinoma: paradigms for viral-related human carcinogenesis

et al. 2006

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“…HBV belongs to the family Hepadnaviridae with a 3.2 kb partially double-stranded circular DNA genome, which encodes four overlapped open reading frames (ORF) including polymerase, core protein, surface antigen, and HBx. HBSP is a splice-generated protein during HBV natural infection and was shown to induce apoptosis (2,3). It contains the first 46 amino acids of the viral polymerase and 47 new amino acids created by splicing (3).…”

Section: Introductionmentioning

confidence: 99%

“…HBSP is a splice-generated protein during HBV natural infection and was shown to induce apoptosis (2,3). It contains the first 46 amino acids of the viral polymerase and 47 new amino acids created by splicing (3). Viral hepatitis is characterized by diffused inflammatory reaction and associated with cell damage and death (4), during which apoptosis plays an important role (5-7).…”

Section: Introductionmentioning

confidence: 99%

The spliced variant of hepatitis B virus protein, HBSP, interacts with Bcl‐2/Bcl‐xl in vitro and induces apoptosis in HepG2 cells

et al. 2008

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SummaryWe have recently reported that the naturally occurring spliced variant of Hepatitis B virus protein, HBSP, displayed proapoptotic activity through its BH3 domain. To investigate whether the BH3 domain in HBSP interacted with Bcl-2 family of proteins, HBSP and Bcl-2 family of proteins were cloned and expressed in our mammalian two-hybrid system. Interaction assays were carried out in HepG2 cells and measured by the activity of the reporter gene product luciferase. Our results indicated that HBSP interacted with Bcl-2/Bcl-xl in vitro and induced apoptosis in HepG2 cells.

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Viral Hepatitis

Rizzetto¹,

Zoulim²

2007

Textbook of Hepatology

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In vivo expression of a new hepatitis B virus protein encoded by a spliced RNA

Cited by 138 publications

References 23 publications

Hepatitis B virus-related hepatocellular carcinoma: paradigms for viral-related human carcinogenesis

Hepatitis B virus-related hepatocellular carcinoma: paradigms for viral-related human carcinogenesis

The spliced variant of hepatitis B virus protein, HBSP, interacts with Bcl‐2/Bcl‐xl in vitro and induces apoptosis in HepG2 cells

Viral Hepatitis

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