In vivo evidence of the targeting of cartilaginous tissue by pyridinium functionalized nanoparticles

Morlieras, Jessica; Chezal, Jean‐Michel; Miot-Noirault, E.; Vidal, Aurélien; Besse, Sophie; Kryza, David; Truillet, Charles; Mignot, A.; Antoine, Rodolphe; Dugourd, Philippe; Rédini, Françoise; Sancey, Lucie; Lux, François; Perriat, Pascal; Janier, Marc; Tillement, Olivier

doi:10.1039/c3cc39106j

Cited by 8 publications

(6 citation statements)

References 14 publications

(18 reference statements)

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“…2 In our study, since GBNs were not yet designed to specifically target HNCSS tumor cells, we preferred to use intra-tumoral injections to better control the local concentration of GBNs, even though an homogeneous distribution of GBNs in the tumor cannot be certain, leading to treatment variability, which may explain the variability in the GBN + 10 Gy group. Three recently published studies by Morlieras et al [41][42][43] reported GBNs functionalized with 3 different ligands targeting tumors rich in melanin, proteoglycans or αvβ3.…”

Section: Discussionmentioning

confidence: 99%

Combining ultrasmall gadolinium-based nanoparticles with photon irradiation overcomes radioresistance of head and neck squamous cell carcinoma

Miladi

Aloy

Armandy

et al. 2015

Nanomedicine: Nanotechnology, Biology and Medicine

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Section: Discussionmentioning

confidence: 99%

Combining ultrasmall gadolinium-based nanoparticles with photon irradiation overcomes radioresistance of head and neck squamous cell carcinoma

Miladi

Aloy

Armandy

et al. 2015

Nanomedicine: Nanotechnology, Biology and Medicine

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“…Such deconvolution approaches with ESI-MS measurements were found to be well-adapted for solving mass distributions of polydisperse gold nanoclusters 51,[160][161][162][163][164][165] as well as for ultrasmall Gd-based silica NPs. [166][167][168][169][170][171][172][173]…”

Section: Mass Spectrometry For Polydisperse Nanoclusters Multiplicative Correlation Algorithmmentioning

confidence: 99%

The emergence of mass spectrometry for characterizing nanomaterials. Atomically precise nanoclusters and beyond

et al. 2021

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“…The nebulisation was performed with 100 MBq/3 mL of 99m Tc-DTPA and 60 MBq/3 mL of 111 In-SRP suspension. The chelation of 111 In on SRP was performed following the protocol developed by Morlieras et al 36 and modified for the purification process. Briefly, the nanoparticles were suspended in milliQ water at the concentration of 100 mg/ mL.…”

Section: Regional Aerosol Deposition Assessed By Gamma-camera Imagingmentioning

confidence: 99%

<p>Nebulised Gadolinium-Based Nanoparticles for a Multimodal Approach: Quantitative and Qualitative Lung Distribution Using Magnetic Resonance and Scintigraphy Imaging in Isolated Ventilated Porcine Lungs</p>

Montigaud¹,

Pourchez²,

Leclerc³

et al. 2020

IJN

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This study aims at determining lung distribution of gadolinium-based polysiloxane nanoparticles, AGuIX ® (small rigid platform-SRP), as a potential theranostic approach by the pulmonary route. Methods: First, the aerodynamic size distribution and the aerosol output rate were thoroughly characterized. Then, a multimodal approach using magnetic resonance (MR) and gamma-camera (GC) imaging allows to assess the deposition of the aerosolised nanoparticles in the respiratory tract using isolated ventilated porcine lungs. Results: The SRP has proven to be radiolabelled by radioisotope with a good yield. Crude SRP or radiolabelled ones showed the same aerodynamic size distribution and output as a conventional molecular tracer, as sodium fluoride. With MR and GC imaging approaches, the nebulised dose represented about 50% of the initial dose of nanoparticles placed in the nebuliser. Results expressed as proportions of the deposited aerosol showed approximately a regional aerosol deposition of 50% of the deposited dose in the lungs and 50% in the upper airways. Each technique assessed a homogeneous pattern of deposited nanoparticles in Lungs. MR observed a strong signal enhancement with the SRP, similar to the one obtained with a commonly used MRI contrast agent, gadoterate meglumine. Conclusion: As a known theranostic approach by intravenous administration, SRP appeared to be easily aerosolised with a conventional nebuliser. The present work proves that pulmonary administration of SRP is feasible in a human-like model and allows multimodal imaging with MR and GC imaging. This work presents the proof of concept of SRP nebulisation and aims to generate preclinical data for the potential clinical transfer of SRP for pulmonary delivery.

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In vivo evidence of the targeting of cartilaginous tissue by pyridinium functionalized nanoparticles

Cited by 8 publications

References 14 publications

Combining ultrasmall gadolinium-based nanoparticles with photon irradiation overcomes radioresistance of head and neck squamous cell carcinoma

Combining ultrasmall gadolinium-based nanoparticles with photon irradiation overcomes radioresistance of head and neck squamous cell carcinoma

The emergence of mass spectrometry for characterizing nanomaterials. Atomically precise nanoclusters and beyond

<p>Nebulised Gadolinium-Based Nanoparticles for a Multimodal Approach: Quantitative and Qualitative Lung Distribution Using Magnetic Resonance and Scintigraphy Imaging in Isolated Ventilated Porcine Lungs</p>

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