In vivo evidence for decreased scyllo-inositol levels in the supplementary motor area of patients with Progressive Supranuclear Palsy: A proton MR spectroscopy study

Barbagallo, Gaetano; Morelli, Maurizio; Quattrone, Andrea; Chiriaco, Carmelina; Vaccaro, Maria Grazia; Gullà, Domenico; Rocca, Federico; Caracciolo, Manuela; Novellino, Fabiana; Sarica, Alessia; Arabia, Gennarina; Sabatini, Umberto; Quattrone, Aldo

doi:10.1016/j.parkreldis.2018.12.008

Cited by 21 publications

(24 citation statements)

References 27 publications

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“…The impact of treatment in MRS studies has been rarely investigated. While some studies reported patients' on or off status during examination and imaging (11, 22, 25, 41–47), for a large number of studies the medication status is unclear (9, 31, 32, 37, 48–56). A recent study found significant metabolic changes in PD subjects between medical on and off state (41).…”

Section: Discussionmentioning

confidence: 99%

Altered Neurometabolic Profile in Early Parkinson's Disease: A Study With Short Echo-Time Whole Brain MR Spectroscopic Imaging

et al. 2019

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Objective: To estimate alterations in neurometabolic profile of patients with early stage Parkinson's disease (PD) by using a short echo-time whole brain magnetic resonance spectroscopic imaging (wbMRSI) as possible biomarker for early diagnosis and monitoring of PD. Methods: 20 PD patients in early stage (H&Y ≤ 2) without evidence of severe other diseases and 20 age and sex matched healthy controls underwent wbMRSI. In each subject brain regional concentrations of metabolites N-acetyl-aspartate (NAA), choline (Cho), total creatine (tCr), glutamine (Gln), glutamate (Glu), and myo-inositol (mIns) were obtained in atlas-defined lobar structures including subcortical basal ganglia structures (the left and right frontal lobes, temporal lobes, parietal lobes, occipital lobes, and the cerebellum) and compared between patients and matched healthy controls. Clinical characteristics of the PD patients were correlated with spectroscopic findings. Results: In comparison to controls the PD patients revealed altered lobar metabolite levels in all brain lobes contralateral to dominantly affected body side, i.e., decreases of temporal NAA, Cho, and tCr, parietal NAA and tCr, and frontal as well as occipital NAA. The frontal NAA correlated negatively with the MDS-UPDRS II ( R = 22120.585, p = 0.008), MDS-UPDRS IV ( R = −0.458, p = 0.048) and total MDS-UPDRS scores ( R = −0.679, p = 0.001). Conclusion: In early PD stages metabolic alterations are evident in all contralateral brain lobes demonstrating that the neurodegenerative process affects not only local areas by dopaminergic denervation, but also the functional network within different brain regions. The wbMRSI-detectable brain metabolic alterations reveal the potential to serve as biomarkers for early PD.

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Section: Discussionmentioning

confidence: 99%

Altered Neurometabolic Profile in Early Parkinson's Disease: A Study With Short Echo-Time Whole Brain MR Spectroscopic Imaging

et al. 2019

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“…PSP-RS patients had reduced cerebellar NAA/Cr and NAA/myo-inositol ratios vs. controls, and reduced cerebellar NAA/Cr ratio vs. PD patients ( 77 ). Compared to controls, PSP patients also showed a decrease in scyllo-inositol concentration (a stereoisomer of inositol) and scyllo-inositol/Cr ratio in the supplementary motor area, and both of these metabolic measures were directly related to attention and working memory functions ( 151 ). The pathological significance of scyllo-inositol reduction in PSP is currently uncertain ( 151 ).…”

Section: Structural Neuroimaging In Parkinsonian Disordersmentioning

confidence: 99%

Neuroimaging Advances in Parkinson's Disease and Atypical Parkinsonian Syndromes

2020

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“…The cohort consisted of 140 subjects, divided in 49 Parkinson's disease patients (PD, mean age ± std 66.7 ± 9.38, 22 females), 48 Progressive Supranuclear Palsy patients (PSP, mean age ± std 70.1 ± 8.32, 22 females), and 44 healthy control subjects (CTRL, mean age ± std 62.6 ± 11.5, 25 females). Clinical diagnosis for PSP patients was established according to the diagnostic criteria for PSP [31][32][33] and clinical diagnosis for PD patients was established according to international diagnostic criteria [34,35]. For each patient, a complete medical history with neurological examination and clinical assessment was performed by trained physicians with more than 10 years of experience in movement disorders.…”

Section: Participantsmentioning

confidence: 99%

A Novel Approach for Cognitive Clustering of Parkinsonisms through Affinity Propagation

et al. 2021

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Cluster analysis is widely applied in the neuropsychological field for exploring patterns in cognitive profiles, but traditional hierarchical and non-hierarchical approaches could be often poorly effective or even inapplicable on certain type of data. Moreover, these traditional approaches need the initial specification of the number of clusters, based on a priori knowledge not always owned. For this reason, we proposed a novel method for cognitive clustering through the affinity propagation (AP) algorithm. In particular, we applied the AP clustering on the regression residuals of the Mini Mental State Examination scores—a commonly used screening tool for cognitive impairment—of a cohort of 49 Parkinson’s disease, 48 Progressive Supranuclear Palsy and 44 healthy control participants. We found four clusters, where two clusters (68 and 30 participants) showed almost intact cognitive performance, one cluster had a moderate cognitive impairment (34 participants), and the last cluster had a more extensive cognitive deficit (8 participants). The findings showed, for the first time, an intra- and inter-diagnostic heterogeneity in the cognitive profile of Parkinsonisms patients. Our novel method of unsupervised learning could represent a reliable tool for supporting the neuropsychologists in understanding the natural structure of the cognitive performance in the neurodegenerative diseases.

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In vivo evidence for decreased scyllo-inositol levels in the supplementary motor area of patients with Progressive Supranuclear Palsy: A proton MR spectroscopy study

Cited by 21 publications

References 27 publications

Altered Neurometabolic Profile in Early Parkinson's Disease: A Study With Short Echo-Time Whole Brain MR Spectroscopic Imaging

Altered Neurometabolic Profile in Early Parkinson's Disease: A Study With Short Echo-Time Whole Brain MR Spectroscopic Imaging

Neuroimaging Advances in Parkinson's Disease and Atypical Parkinsonian Syndromes

A Novel Approach for Cognitive Clustering of Parkinsonisms through Affinity Propagation

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