In Vivo Evaluation of Sciatic Nerve Crush Injury Using Diffusion Tensor Imaging

Sun, Chongpeng; Hou, Zhongjun; Hong, Guobin; Wan, Qing; Li, Xinchun

doi:10.1097/rct.0000000000000118

Cited by 14 publications

(11 citation statements)

References 19 publications

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“…Alterations in DTI-derived metrics are believed to reflect changes in peripheral nerve microstructure and overall ‘nerve health’ [ 12 ]. Recent studies have demonstrated good correlation between DTI and functional and histologic parameters in assessing nerve regeneration in rodent models [ 8 , 13 ] and rabbit models [ 14 – 17 ].…”

Section: Introductionmentioning

confidence: 99%

Evaluation of two collagen conduits and autograft in rabbit sciatic nerve regeneration with quantitative magnetic resonance DTI, electrophysiology, and histology

et al. 2018

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BackgroundWe compared different surgical techniques for nerve regeneration in a rabbit sciatic nerve gap model using magnetic resonance diffusion tensor imaging (DTI), electrophysiology, limb function, and histology.MethodsA total of 24 male New Zealand white rabbits were randomized into three groups: autograft (n = 8), hollow conduit (n = 8), and collagen-filled conduit (n = 8). A 10-mm segment of the rabbit proximal sciatic nerve was cut, and autograft or collagen conduit was used to bridge the gap. DTI on a 3-T system was performed preoperatively and 13 weeks after surgery using the contralateral, nonoperated nerve as a control.ResultsOverall, autograft performed better compared with both conduit groups. Differences in axonal diameter were significant (autograft > hollow conduit > collagen-filled conduit) at 13 weeks (autograft vs. hollow conduit, p = 0.001, and hollow conduit vs. collagen-filled conduit, p < 0.001). Significant group differences were found for axial diffusivity but not for any of the other DTI metrics (autograft > hollow conduit > collagen-filled conduit) (autograft vs. hollow conduit, p = 0.001 and hollow conduit vs. collagen-filled conduit, p = 0.021). As compared with hollow conduit (autograft > collagen-filled conduit > hollow conduit), collagen-filled conduit animals demonstrated a nonsignificant increased maximum tetanic force.ConclusionsAutograft-treated rabbits demonstrated improved sciatic nerve regeneration compared with collagen-filled and hollow conduits as assessed by histologic, functional, and DTI parameters at 13 weeks.Electronic supplementary materialThe online version of this article (10.1186/s41747-018-0049-2) contains supplementary material, which is available to authorized users.

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Section: Introductionmentioning

confidence: 99%

Evaluation of two collagen conduits and autograft in rabbit sciatic nerve regeneration with quantitative magnetic resonance DTI, electrophysiology, and histology

et al. 2018

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“…Recent studies have demonstrated that this technique can also be used in the study of peripheral nerves (8) , although we found no studies with an emphasis on the specific evaluation of sciatic nerve abnormalities in humans. Recent experimental studies involving animal models of crush injury and sciatic nerve traction injury showed that DTI tractography, using routine clinical 1.5 T MRI scanners, is a promising tool in the assessment of sciatic lesions (9,10) . In those studies, DTI was able to differentiate between nerves with nerve damage and control group nerves.…”

Section: Introductionmentioning

confidence: 99%

Sciatic neuropathy: findings on magnetic resonance neurography

Agnollitto

Chu²,

Simão

et al. 2017

Radiol Bras

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Injuries of the sciatic nerve are common causes of pain and limitation in the lower limbs. Due to its particular anatomy and its long course, the sciatic nerve is often involved in diseases of the pelvis or leg. In recent years, magnetic resonance neurography has become established as an important tool for the study of peripheral nerves and can be widely applied to the study of the sciatic nerve. Therefore, detailed knowledge of its anatomy and of the most prevalent diseases affecting it is essential to maximizing the accuracy of diagnostic imaging.

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“…The pattern identified here is similar to recent DTI studies at lower field strength in patients with CTS 24 , 36 , 37 or other peripheral neuropathies. 31 , 38 , 39 Reduced FA and increased RD are also the predominant findings in experimental nerve injury models, where they correlate with histological markers of axon and myelin degeneration, 40 – 42 or the presence of inflammation-induced edema. 43 In humans, correlation of diffusion parameters with electrodiagnostic parameters thought to reflect axonal damage or demyelination reveal conflicting outcomes.…”

Section: Discussionmentioning

confidence: 95%