In vivo evaluation of retinal and callosal projections in early postnatal development and plasticity using manganese-enhanced MRI and diffusion tensor imaging

Chan, Kevin C.; Cheng, Joe S.; Fan, Shujuan; Zhou, Iris Y.; Yang, Jian; Wu, Ed X.

doi:10.1016/j.neuroimage.2011.09.055

Cited by 45 publications

(59 citation statements)

References 98 publications

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“…2) (Chan et al, 2012;Chen et al, 2008Chen et al, , 2011Duong, 2014;Wang et al, 2011). This 23.4 mm resolution is important because it allows for the collection of MRI data that can distinguish inner retina structure/ function from that in the outer retina aided by the 200 mm thick retina having a well-defined laminar structure (Berkowitz et al, 2009a(Berkowitz et al, , 2012a(Berkowitz et al, , 2007dBissig and Berkowitz, 2011).…”

Section: Breakthroughmentioning

confidence: 99%

MRI of rod cell compartment-specific function in disease and treatment in vivo

Berkowitz

Bissig

Roberts

2016

Progress in Retinal and Eye Research

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Rod cell oxidative stress is a major pathogenic factor in retinal disease, such as diabetic retinopathy (DR) and retinitis pigmentosa (RP). Personalized, non-destructive, and targeted treatment for these diseases remains elusive since current imaging methods cannot analytically measure treatment efficacy against rod cell compartment-specific oxidative stress in vivo. Over the last decade, novel MRI-based approaches that address this technology gap have been developed. This review summarizes progress in the development of MRI since 2006 that enables earlier evaluation of the impact of disease on rod cell compartment-specific function and the efficacy of anti-oxidant treatment than is currently possible with other methods. Most of the new assays of rod cell compartment-specific function are based on endogenous contrast mechanisms, and this is expected to facilitate their translation into patients with DR and RP, and other oxidative stress-based retinal diseases.

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Section: Breakthroughmentioning

confidence: 99%

MRI of rod cell compartment-specific function in disease and treatment in vivo

Berkowitz

Bissig

Roberts

2016

Progress in Retinal and Eye Research

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“…A practical example in this context can be found in a study by Chan et al (2012), who assessed the effects of early visual impairment i.e. monocular enucleation and monocular deprivation -a popular model for critical period ocular dominance plasticityin rodents by combining DTI and Manganese Enhanced MRI (MEMRI; Table 1).…”

Section: The Impact Of Age On Neuroplasticitymentioning

confidence: 99%

“…Interestingly, the non-deprived eye was characterized by a higher FA compared to control rats (Chan, A C C E P T E D M A N U S C R I P T Cheng et al 2012). Besides its use in probing structural connectivity, DTI is sensitive to microstructural rearrangements and changing myelin content as well, both factors known to be implicated in limiting neuroplasticity.…”

Section: The Impact Of Age On Neuroplasticitymentioning

confidence: 99%

Neuroplasticity and MRI: A perfect match

2016

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Numerous studies have illustrated the benefits of physical workout and cognitive exercise on brain function and structure and, more importantly, on decelerating cognitive decline in old age and promoting functional rehabilitation following injury. Despite these behavioral observations, the exact mechanisms underlying these neuroplastic phenomena remain obscure. This gap illustrates the need for carefully designed in-depth studies using valid models and translational tools which allow to uncover the observed events up to the molecular level. We promote the use of in vivo magnetic resonance imaging (MRI) because it is a powerful translational imaging technique able to extract functional, structural, and biochemical information from the entire brain. Advanced processing techniques allow performing voxel-based analyses which are capable of detecting novel loci implicated in specific neuroplastic events beyond traditional regions-of-interest analyses. In addition, its non-invasive character sets it as currently the best global imaging tool for performing dynamic longitudinal studies on the same living subject, allowing thus exploring the effects of experience, training, treatment etc. in parallel to additional measures such as age, cognitive performance scores, hormone levels, and many others. The aim of this review is (i) to introduce how different animal models contributed to extend the knowledge on neuroplasticity in both health and disease, over different life stages and upon various experiences, and (ii) to illustrate how specific MRI techniques can be applied successfully to inform on the fundamental mechanisms underlying experience-dependent or activity-induced neuroplasticity including cognitive processes.

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“…[2][3][4][5] Quantitative analyses of the physical properties of molecules in tissue, such as water diffusion, relaxation parameters T 1 , T 2 and T 2 * or magnetization transfer provide valuable information on tissue microstructure. 6,7 Beyond anatomy, functional MRI (fMRI) can measure physiological processes such as tissue perfusion, heart function and brain activity. [8][9][10][11] Importantly, the non-invasive nature of the technique enables the repetitive assessment of animals, which is attractive not only from an animal welfare perspective but also in view of the high value of genetically engineered mice.…”

Section: Mouse Models In Biomedical Researchmentioning

confidence: 99%