In Vivo Evaluation of Effect of Preoperative Ibuprofen on Proinflammatory Mediators in Irreversible Pulpitis Cases

Nguyen, Vicky T.; Chen, Yen‐Wei; Johnson, James D.

doi:10.1016/j.joen.2020.06.009

Cited by 13 publications

(7 citation statements)

References 37 publications

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“…It has been shown that after bacterial infiltration, this cytokine is synthesized and released by a multitude of cell types and there are well-known correlations between TNF-α levels in the infected pulp tissue and experienced pain by patients. [38][39][40][41] Moreover, this cytokine with bacterial LPS in infected pulp activates NF-κB signaling pathway. [42] It has been shown that the activation of this pathway could be caused by different patterns, which lead to the production of other proinflammatory cytokines such as IL-1β, -8, and -6.…”

Section: Discussionmentioning

confidence: 99%

Synthesis, characterization, and evaluation of curcumin‐loaded endodontic reparative material

Alipour

Fadakar

Aghazadeh

et al. 2021

J Biochem & Molecular Tox

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Curcumin (CUR) is an ancient therapeutic agent with remarkable antimicrobial and antiinflammatory properties. The purpose of the current study was to synthesize and evaluate a curcumin-based reparative endodontic material to reduce infection and inflammation besides the induction of mineralization during the healing of the dentin-pulp complex.Poly-ɛ-caprolactone (PCL)/gelatin (Gel)/CUR scaffold was synthesized and assessed by scanning electron microscopy, Fourier transform infrared spectroscopy, and thermogravimetric analysis (TGA). Agar diffusion test was performed against E. coli, A. baumannii, P. aeruginosa, S. aureus, E. faecalis, and S. mutans. Moreover, proliferative, antioxidative, anti-inflammatory, and calcification properties of these scaffolds on human dental pulp stem cells (hDPSCs) were evaluated. The results showed that PCL/Gel/CUR scaffold had antibacterial effects. Also, these CUR-based scaffolds had significant inhibitory effects on the expression of tumor necrosis factor α and DCF from inflamed hDPSCs (p < 0.05).Moreover, the induction of mineralization in hDPSCs significantly increased after seeding on CUR-based scaffolds (p < 0.05). Based on these findings, the investigated CUR-loaded material was fabricated successfully and provided an appropriate structure for the attachment and proliferation of hDPSCs. It was found that these scaffolds had antimicrobial, antioxidant, and anti-inflammatory characteristics and could induce mineralization in hDPSCs, which is essential for healing and repairing the injured dentin-pulp complex.

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Section: Discussionmentioning

confidence: 99%

Synthesis, characterization, and evaluation of curcumin‐loaded endodontic reparative material

Alipour

Fadakar

Aghazadeh

et al. 2021

J Biochem & Molecular Tox

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“…Currently, it is well known that ibuprofen treatment is capable of significantly inhibiting the synthesis of arachidonic acid metabolites during pulp inflammation (Hutchins et al, 1999; Lessard et al, 1986). Furthermore, a recent study showed that ibuprofen significantly decreased the levels of PGE 2 , TNF‐α, interleukin (IL)‐6, IL‐1β and interferon (IFN)‐γ in patients with irreversible pulpitis (Nguyen et al, 2020). These findings are consistent with the results of the present study, since it was observed that ibuprofen treatment significantly decreased the plasma levels of TNF‐α at 14 and 18 hours after pulp damage.…”

Section: Discussionmentioning

confidence: 99%

Effect of treatment with resiniferatoxin in an experimental model of pulpal inflammatory in mice

et al. 2021

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Aim To evaluate whether treatment with resiniferatoxin (RTX) is capable of lowering the plasma levels of PGE2 and TNF‐α, as well as histopathological parameters in inflammation of pulp tissue in a mouse experimental model. Methodology Ten groups of six BALB/c mice were formed as follows: healthy group (HC), healthy group treated with RTX (HRTX), two groups with pulp inflammation at 14 and 18 hours (PI14/PI18), six groups with pulpal inflammation plus treatment with Ibuprofen (IBU14/IBU18), dexamethasone (DEX14/DEX18) and resiniferatoxin (RTX14/RTX18) at 14 and 18 hours, respectively. Pulpal inflammation was induced through occlusal exposure of the pulp of the maxillary first molar. The plasma levels of PGE2 and TNF‐α and the histological parameters of the pulp tissue of the HC and HRTX groups were evaluated at the time of acquiring the animals. In the other groups, the plasma levels of PGE2 and TNF‐α and the histopathological parameters were evaluated at 14 and 18 hours after pulp damage. Plasma levels of PGE2 and TNF‐α were quantified by ELISA, and the histopathological parameters were evaluated by H/E staining. Statistical significance was determined by one‐way analysis of variance (ANOVA) to test for overall differences between group means. Results A significant increase (*p < .05) in plasma levels of PGE2 and TNF‐α occurred 14 and 18 hours after pulp damage. In addition, treatment with RTX significantly decreased (*p < .05) the plasma levels of PGE2 and TNF‐α at 14 and 18 hours after pulp damage, as well as the infiltrate of inflammatory cells at 18 hours after pulp damage, similarly to treatment with ibuprofen and dexamethasone. Conclusion It was possible to detect systemic levels of PGE2 and TNF‐α at 14 and 18 hours after pulp damage. Likewise, treatment with RTX was associated with an anti‐inflammatory effect similar to treatment with ibuprofen and dexamethasone. These findings place resiniferatoxin as a therapeutic alternative in the treatment of inflammatory diseases in Dentistry.

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“…The outcome of SARS-CoV-2 not only infected patients, but also the immunopathology and pathogenesis of MERS, and SARS are strongly associated with the level of expression of inflammatory cytokines. This is because even by suppressing antiviral therapy using viral replication, the pro-inflammatory cytokines keeps driving the immunopathologic progression [25][26][27][28][29]. High serum levels of proinflammatory cytokines, including IL-1β, IL-6, IFN-γ and TNF-a have been reported in patients with severe cases of COVID-19.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Anti-Inflammatory Effects of Naproxen on Pro-Inflammatory Cytokines in COVID-19 Patients

Abolnezhadian¹,

Khosravi²,

Makvandi³

et al. 2021

austinjinfectdis

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The new Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection was declared by the World Health Organization as pandemic in the early 2020. The clinical spectrum of coronavirus disease 2019 (COVID-19) include asymptomatic and symptomatic cases, including dry cough, fatigue, fever, shortness of breath, and gastrointestinal symptoms. However, increased immune inflammatory responses to stimuli can result in the overproduction of pro-inflammatory cytokines, immunopathological complications and death in patients infected with COVID-19. Given the anti-inflammatory effects of Naproxen, this study evaluated the effect of naproxen on IL-1β, TNF-a, IL-6, IFN-γ and TGF-β in COVID-19 patients. According to the results, the serum levels of IFN-γ and TGF-β cytokines significantly decreased in the patients after the treatment with naproxen. In addition, the naproxen treatment was found effective in reducing the serum level of IL-6 and IL-1β in patients with COVID-19, though it did not significantly change the serum level of TNF-a. Overall, the findings demonstrated the effectiveness of naproxen on pro-inflammatory cytokines by regulating their serum levels in COVID-19 patients.

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In Vivo Evaluation of Effect of Preoperative Ibuprofen on Proinflammatory Mediators in Irreversible Pulpitis Cases

Cited by 13 publications

References 37 publications

Synthesis, characterization, and evaluation of curcumin‐loaded endodontic reparative material

Synthesis, characterization, and evaluation of curcumin‐loaded endodontic reparative material

Effect of treatment with resiniferatoxin in an experimental model of pulpal inflammatory in mice

Evaluation of Anti-Inflammatory Effects of Naproxen on Pro-Inflammatory Cytokines in COVID-19 Patients

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