In vivo Evaluation of Antidiabetic Properties of Seed Oil of Moringa oleifera Lam

Busari, Musa Bola; Muhammad, Hadiza Lami; Ogbadoyi, Emmanuel O.; Kabiru, Adamu Yusuf; Sani, S.; Yusuf, Ruqayyah S.

doi:10.9734/jalsi/2015/16048

Cited by 17 publications

(12 citation statements)

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“…2). The findings of the present study are at variance with the observations and report of organ (tissue) hyperplasia concomitant with toxicants [59]. Therefore, it is suggestive that S. glauca did not elicit significant aberration capable of architectural alteration of vital organs such as the liver, kidney and heart respectively (Plates I-XII).…”

Section: Discussioncontrasting

confidence: 81%

“…A large number of herbal preparations do not have drug regulatory approval to demonstrate their safety and efficacy [58]; therefore, it is obligatory to evaluate the safety of medicinal plants preparations and decoction via toxicological assessment studies on vital organs. Alterations, particularly increase in organ to body weight ratio may indicate toxicity-induced organ damage [59], tissue hyperplasia and enlargement of organs which are often signs of organ stress.…”

Section: Discussionmentioning

confidence: 99%

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Oral Acute & Sub-Chronic Toxicity Assessment of Ethanol Leaf Extract of Simarouba glauca

Osagie-Eweka

Orhue

Omogbai

et al. 2020

IJBcRR

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Traditional herbal medicine and their preparations have been widely used for thousands of years and are still in use in developing and developed countries owing to their medicinal values and their presumed relative safety. This belief that medicinal plants are not toxic or are with less side effect due to their natural origin is debatable; hence this study was conducted to evaluate the safety and (or) toxicity of Ethanol leaf extract of Simarouba glauca (EESG) on liver, kidney and heart functions of Wistar rats. The oral acute toxicity of EESG was evaluated in line with Lorke’s method. The sub-chronic toxicity of EESG was carried out according to the OECD guidelines with modification and using a total of twenty-four (24) male Wistar rats; divided into four groups of six rats each, following a two-week acclimatization. Test rats were orally administered EESG at doses of 500, 1000 and 2000 mg/kg body weight respectively daily for thirty (30) days, while the control was given only feed and water ad libitum. At the end of the experiment, the rats were fasted overnight and sacrificed under chloroform anesthesia; relevant biochemical and histopathology analyses were carried out. The data obtained from the oral acute test indicate that the LD50 was above 5000 mg/kg and there was no death recorded. There were significant increases (P ˂ 0.05) in percentage (%) body weight of rats administered respective doses of EESG. There were significant reductions (P˂0.05) in mean liver: body weight ratio of rats administered EESG 500 and 2000 mg/kg respectively, significant reductions (P˂0.05) in mean kidney: body weight ratios of rats given EESG 1000 and 2000 mg/kg respectively; significant reductions (P˂0.05) in mean heart: body weight ratios of test rats administered EESG 2000 mg/kg; whereas others were not significantly different (P˃0.05) relative to their respective control. Plasma ALT and GGT activities of rats administered respective dose of EESG were significantly reduced (P˂0.05); plasma ALP activities were significantly elevated (P˂0.05) relative to the control after 30 days. There were no significant differences (P˃0.05) in plasma total proteins and albumin levels. Plasma total and unconjugated bilirubin of rats administered respective dose of EESG were not significantly different (P˃0.05); whereas, rats given EESG recorded significant reduction in plasma conjugated bilirubin. Plasma urea was significantly elevated (P˂0.05) in rats administered EESG 1000 and 2000 mg/kg respectively. Test rats given EESG 500 and 1000 mg/kg respectively recorded significant elevations in plasma creatinine and rats given EESG 2000 mg/kg recorded significant decrease in plasma creatinine levels; others were not significantly different relative to the control. Plasma chloride and potassium ion levels of rats administered respective doses of EESG were not significantly different (P˃0.05); significant reduction (P˂0.05) in plasma sodium ions concentration in all group compared to the control. Plasma calcium ion levels in all group were not significantly different (P˃0.05); whereas there were significant reductions (P˂0.05) in plasma bicarbonate ion levels relative to their respective controls. Although plasma ALP activity were significantly elevated, there were no elevations in specific liver function enzymes and no visible hepatocellular damage. Furthermore, the conspicuous elevations observed in plasma urea and creatinine levels do not exclusively indicate EESG-induced organ injury. Therefore, it is suggestive that EESG was not significantly toxic to the to the liver, kidney and heart respectively and may be administered at lower doses in further studies.

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Section: Discussioncontrasting

confidence: 81%

Section: Discussionmentioning

confidence: 99%

Oral Acute & Sub-Chronic Toxicity Assessment of Ethanol Leaf Extract of Simarouba glauca

Osagie-Eweka

Orhue

Omogbai

et al. 2020

IJBcRR

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“…The performance of an experiment in which rats are exposed to a toxic product results in damage, either by an increase or decrease in the relative weight of the organs of metabolism such as liver, kidneys, spleen, heart, and lung (Busari et al, 2015). In this study, there was virtually no significant difference in the relative weight of liver, kidneys, spleen, heart, and lung organs between the test groups and those of the control group.…”

Section: Discussionmentioning

confidence: 45%

Botanical from the medicinal spice, Piper capense is safe as demonstrated by oral acute and subchronic toxicity investigations

Wamba

Mbaveng

Tazoho

et al. 2020

Heliyon

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“…Alterations, particularly organ hyperplasia to body weight ratio, may indicate toxicity-induced organ damage [ 59 ]. Although, there was mild congestion in hepatic central vein and inflamed periportal cells of experimental rats administered AESG, this might be attributed to toxicity associated with the lengthy administration of extracts at rather very high doses.…”

Section: Discussionmentioning

confidence: 99%

Oral acute and sub-chronic toxicity assessment of aqueous leaf extract of Simarouba glauca DC (Paradise tree)

et al. 2021

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In vivo Evaluation of Antidiabetic Properties of Seed Oil of Moringa oleifera Lam

Cited by 17 publications

References 0 publications

Oral Acute & Sub-Chronic Toxicity Assessment of Ethanol Leaf Extract of Simarouba glauca

Oral Acute & Sub-Chronic Toxicity Assessment of Ethanol Leaf Extract of Simarouba glauca

Botanical from the medicinal spice, Piper capense is safe as demonstrated by oral acute and subchronic toxicity investigations

Oral acute and sub-chronic toxicity assessment of aqueous leaf extract of Simarouba glauca DC (Paradise tree)

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