In vivo Evaluation of Anti-Hyperglycemic, Anti-hyperlipidemic and Anti-Oxidant Status of Liver and Kidney of Thymol in STZ-Induced Diabetic Rats

Oskouei, Bijan; Abbaspour‐Ravasjani, Soheil; Musavinejad, Seyed Jamal; Salehzadeh, Seyed Ahmad; Abdolhosseinzadeh, Alireza; Hamishehkar, Hamed; Ghahremanzadeh, Kazem; Shokouhi, Behrooz

doi:10.1055/a-0646-3803

Cited by 17 publications

(15 citation statements)

References 29 publications

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“…Also, the results from this study showed that in the groups treated with thymol and thymol nano polymer, as with the diabetic group treated with glibenclamide, serum insulin levels significantly increased compared to the diabetic group. Previous studies, in confirmation of our study, have shown that increase blood glucose levels and decrease insulin levels in STZ diabetic rats, confirmed that hyperglycemia is a main cause for disruption of insulin in the optimal rate [16,41,42] Moreover, in one research treatment by thymol led to a significant reduces in the blood glucose level and increase in serum insulin level after 28 d in the STZinduced diabetic rats [48]. However, the anti-diabetic mechanism of thymol, which is responsible for increasing the rate of serum insulin secretion and decreasing of blood glucose, is still unclear [42].…”

supporting

confidence: 90%

“…ALT and AST are the important hepatic enzymes due to their levels in serum as the specific and reliable biomarker for liver damages [42,49,50]. In confirmation of our results, it was shown in a paper that thymol 40 mg/kg has been able to significantly reduce ALT and AST in diabetic rats by STZ and help animal health [48]. It has been documented that the Zataria multiflora essential oil has been able to protect the increase of ALP produced by STZ in diabetic rats [51].…”

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confidence: 82%

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Anti-Diabetic Effect of a Novel Nano Polymer of Thymol in Streptozotocin-Induced Diabetic Wistar Rats

et al. 2019

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Objective: The aim of this study was to evaluate the effect of thymol and thymol nano polymer on the blood biochemical parameters and anti-diabetic activity in Streptozotocin (STZ)-induced diabetic rats. Methods: The synthesized nano polymer (NP) was characterized by using different spectroscopy methods, such as IR, HNMR and CNMR. Loading and releasing of thymol were investigated by HPLC. Eleven groups of the Streptozotocin-induced diabetic and normal rats (overall 110 males) were tested through various biochemical factors such as: serum glucose, insulin, liver function-related enzymes including ALT, AST, ALP and bilirubin by ELISA kit methods. Results: It has shown that thymol nano polymer is desirable for transferring drug. The amount of thymol loaded on NP estimated at 43±2.5 %. Then, 65% of the loaded drug was released. LD50 for thymol and thymol nano polymer were 435 and 583 mg/kg, respectively. thymol nano polymer at doses of 30, 60 and 90 mg/kg, in a dose-dependent manner, reduced blood glucose, increased insulin levels, and controlled liver enzymes ALT, AST, ALP and bilirubin in the STZ-induced diabetic rats. Conclusion: The use of thymol nano polymer appears to be a new aspect concerning to protect diabetes-induced damage in the animal model.

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supporting

confidence: 90%

supporting

confidence: 82%

Anti-Diabetic Effect of a Novel Nano Polymer of Thymol in Streptozotocin-Induced Diabetic Wistar Rats

et al. 2019

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“…The difference test between groups was performed by one-way ANOVA, be continued using post hoc Tukey. The one-way analysis of variance (ANOVA) is used to evaluate if there are any statistically significant discrepancies between the means of two or more distinct (unrelated) groups [15,16].…”

Section: Discussionmentioning

confidence: 99%

Klutuk Banana (Musa Balbisiana Colla) Peel Fractions: Antioxidant and Antihyperglycemic Potential

et al. 2021

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Objective: The purposes of this research were the antihyperglycemic and antioxidant determination of klutuk banana peel fractions through the oral glucose tolerance test (OGTT) and DPPH (2,2-diphenyl-1-picrylhydrazyl) methods, respectively. Methods: Klutuk banana peel was extracted by reflux method and followed by fractionation using n-hexane and ethyl acetate solvents by liquid-liquid extraction method. The statistical analysis used by one-way ANOVA and post hoc Tukey. Results: The results of OGTT showed that ethyl acetate fraction of klutuk banana peel 14.5 mg/kg bw demonstrated higher activity to decrease blood glucose level compared to the other groups as much-32%,-49%,-47% and-40% at min 30, 60, 90 and 120, respectively. The IC50 of ethyl acetate fraction of klutuk banana peel was 0.3708 µg/ml, and its antioxidant activity index (AAI) 40.45. Conclusion: The ethyl acetate fraction of klutuk peel presented very strong antioxidant and antihyperglycemic activity.

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“…The SPSS package (version 16) was applied in statistical analysis. The comparison between groups was performed by one-way ANOVA, followed by post hoc Tukey [15,16].…”

Section: Discussionmentioning

confidence: 99%

Comparison of Antihyperglycemic Activity of Different Parts of Klutuk Banana (Musa Balbisiana Colla)

2021

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Objective: Banana is a plant that grows in Indonesia and is widely consumed by Indonesian people. One of banana type is klutuk banana (Musa balbisiana Colla). There were many types of researches about klutuk banana for antidiabetic activity; however, antidiabetic activity of its peel and pulp are still unknown. Methods: The objective of the study was to determine of antihyperglycemic activity of different parts of klutuk banana. Animals were divided into 15 groups, namely normal control, negative control, positive control (glibenclamide 0.65 mg/kg body weight (bw), and 12 sample groups. All animals were given 2 g/kg bw glucose monohydrate and blood glucose level was measured every 30 min for 120 min. Results: The results of the oral glucose tolerance test (OGTT) showed that KPE2 (klutuk peel extract 350 mg/kg bw) gave higher activity to decrease blood glucose level compared to the other groups at the minute of 30 (-24.83%; p. 0.00), 60 (-33.93%; p. 0.000), 90 (-46.29%; p. 0.000) and 120 (-35.44%; p. 0.000). Conclusion: The klutuk peel extract has very strong antioxidant activity and antihyperglycemic activity at a dose of 350 mg/kg bw.

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In vivo Evaluation of Anti-Hyperglycemic, Anti-hyperlipidemic and Anti-Oxidant Status of Liver and Kidney of Thymol in STZ-Induced Diabetic Rats

Abstract: The results of this research has brough a new aspect concerning the proteevtive and positive effects of thymol on the diabetic complications in the animal model.

Cited by 17 publications

References 29 publications

Anti-Diabetic Effect of a Novel Nano Polymer of Thymol in Streptozotocin-Induced Diabetic Wistar Rats

Anti-Diabetic Effect of a Novel Nano Polymer of Thymol in Streptozotocin-Induced Diabetic Wistar Rats

Klutuk Banana (Musa Balbisiana Colla) Peel Fractions: Antioxidant and Antihyperglycemic Potential

Comparison of Antihyperglycemic Activity of Different Parts of Klutuk Banana (Musa Balbisiana Colla)

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