In vivo evaluation of [123I]-3-(4-iodobenzyl)-1,2,3,4-tetrahydro-8-hydroxychromeno[3,4-c]pyridin-5-one: a presumed dopamine D4 receptor ligand for SPECT studies

Staelens, Ludovicus; Oltenfreiter, Ruth; Blanckaert, Peter; Kersemans, Veerle; Vandenbulcke, Katia; Wiele, Christophe Van de; Slegers, Guido

doi:10.1016/j.nucmedbio.2004.12.006

Cited by 5 publications

(3 citation statements)

References 16 publications

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“…190 However, progress has been made in identifying brain regions involved in facets of Novelty Seeking. For example Passamonti et al 191 have identified brain areas involved in impulsivity and the role of a specific polymorphism in their activation.…”

Section: Beyond Self-report Temperament Measuresmentioning

confidence: 99%

The molecular genetic architecture of human personality: beyond self-report questionnaires

2006

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Molecular genetic studies of personality began with two high impact papers in 1996 that showed provisional associations between the dopamine DRD4 exon III repeat region and Novelty Seeking/Extraversion. These first two reports were shortly followed by an investigation linking Neuroticism/Harm Avoidance with the serotonin transporter (SLC6A4) promoter region polymorphism (5-HTTLPR). In the ensuing decade, thousands of subjects have been studied for association between these genes and personality, assessed by using self-report questionnaires, with erratic success in replication of the first findings for Novelty Seeking (DRD4) and Harm Avoidance (5-HTTLPR). Small effect sizes characteristic of non-Mendelian traits, polygenic patterns of inheritance and true heterogeneity between studies confound attempts to reach a consensus regarding the role of common polymorphisms in contributing to personality domains. Nevertheless, the current state of personality genetics is far from being bleak. Several new paradigms especially functional neuroimaging or 'imaging genomics' have strengthened the connection between 5-HTTLPR and anxiety-related personality traits. The demonstrations that early environmental information can considerably strengthen and even uncover associations between genes and behavior (Caspi's seminal studies and more recently the demonstration that early environment impacts on DRD4 and Novelty Seeking) are notable and herald a new era of personality genetics. Finally, consideration of the broader phenotypic expression of common polymorphisms (e.g. the 'social brain', altruism, etc.) and the use of new experimental paradigms including neurophysiological, neuropsychological and computer games that go beyond the narrow self-report questionnaire design will enable a deeper understanding of how common genetic polymorphisms modulate human behavior. Human personality, defined by Webster as the quality or state of being a person or the complex of characteristics that distinguishes an individual, surely requires a more encompassing view towards understanding its complex molecular genetic architecture.

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Section: Beyond Self-report Temperament Measuresmentioning

confidence: 99%

The molecular genetic architecture of human personality: beyond self-report questionnaires

2006

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“…The Fe 3 O 4 nanoparticles had a high saturation magnetization (71 emu/g) and were of a small coercivity (17 Oe) according to our previous work (Sun et al 2005). In particle size of 12± 3 nm which is far less than the critical value of 25 nm for superparamagnetism (Staelens et al 2005;Huang et al 2003), the Fe 3 O 4 nanoparticles were superparamagnetic. Crystal structures of the Fe 3 O 4 nanoparticles and MPEGmodified magnetic nanogels were characterized by XRD (Fig.…”

Section: Magnetic Property Of the Mpeg-modified Magnetic Nanogelsmentioning

confidence: 70%

“…2.4. The animal experiment was conducted in compliance with the Chinese animal protection laws and with the ethical principles and guidelines for scientific animal trials (Staelens et al 2005). Five experimental rabbits were divided randomly into two groups, i.e.…”

Section: Radiolabeling Of Mpeg-modified Magnetic Nanogels With 188 Rementioning

confidence: 99%

188Re-labeled MPEG-modified superparamagnetic nanogels: preparation and targeting application in rabbits

Sun

Zhang

et al. 2007

Biomed Microdevices

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Polyacrylamide-coated magnetic nanogels were synthesized via photochemical method in surfactants and initiators free aqueous system at room temperature. After Hoffmann elimination of carbonyl and further modification with methoxy poly(ethylene glycol) (MPEG), the MPEG-modified superparamagnetic nanogels (MSN) with better hydrophilicity and biocompatibility were obtained. The MSN were characterized by FTIR, XRD, SEM and PCS. Covalently linked with 188Re complex, the 188Re-labeled MSN were prepared and intravenously injected into the left ears of the anesthetized rabbits in control group (without external magnetic field) or in targeting group (in presence of external magnetic field). The average radioactivity distribution of organs in control group was detected and the magnetic targeting feature was investigated in targeting group.

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6‐[¹²³I]Iodo‐2‐[[4‐(2‐methoxyphenyl) piperazin‐1‐yl]methyl]imidazo[1,2‐a]pyridine as potential SPECT agent for imaging dopamine D₄ receptor: synthesis and in vivo evaluation in a nonhuman primate

Alagille

Koren

Kudej

et al. 2008

Labelled Comp Radiopharmac

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aThe dopamine D 4 receptor subtype has drawn considerable attention due to its potential implication in schizophrenia and erectile dysfunction. 6-]-1, a potent and selective new dopamine D 4 agonist, was synthesized by classical iododestannylation using sodium [123 I]iodide and chloramine-T. Radiolabeling yield varied from 34 to 38% with a radiochemical purity exceeding 99%. Despite a good in vitro profile, in vivo evaluation of this radioligand in baboon showed no brain uptake after i.v. injection.

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In vivo evaluation of [123I]-3-(4-iodobenzyl)-1,2,3,4-tetrahydro-8-hydroxychromeno[3,4-c]pyridin-5-one: a presumed dopamine D4 receptor ligand for SPECT studies

Cited by 5 publications

References 16 publications

The molecular genetic architecture of human personality: beyond self-report questionnaires

The molecular genetic architecture of human personality: beyond self-report questionnaires

188Re-labeled MPEG-modified superparamagnetic nanogels: preparation and targeting application in rabbits

6‐[¹²³I]Iodo‐2‐[[4‐(2‐methoxyphenyl) piperazin‐1‐yl]methyl]imidazo[1,2‐a]pyridine as potential SPECT agent for imaging dopamine D₄ receptor: synthesis and in vivo evaluation in a nonhuman primate

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In vivo evaluation of [123I]-3-(4-iodobenzyl)-1,2,3,4-tetrahydro-8-hydroxychromeno[3,4-c]pyridin-5-one: a presumed dopamine D4 receptor ligand for SPECT studies

Cited by 5 publications

References 16 publications

The molecular genetic architecture of human personality: beyond self-report questionnaires

The molecular genetic architecture of human personality: beyond self-report questionnaires

188Re-labeled MPEG-modified superparamagnetic nanogels: preparation and targeting application in rabbits

6‐[123I]Iodo‐2‐[[4‐(2‐methoxyphenyl) piperazin‐1‐yl]methyl]imidazo[1,2‐a]pyridine as potential SPECT agent for imaging dopamine D4 receptor: synthesis and in vivo evaluation in a nonhuman primate

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6‐[¹²³I]Iodo‐2‐[[4‐(2‐methoxyphenyl) piperazin‐1‐yl]methyl]imidazo[1,2‐a]pyridine as potential SPECT agent for imaging dopamine D₄ receptor: synthesis and in vivo evaluation in a nonhuman primate