188Re-labeled MPEG-modified superparamagnetic nanogels: preparation and targeting application in rabbits

Sun, Haijie; Zhang, Lianying; Zhang, Xiuling; Zhang, Cun-Lan; Wei, Zhenlin; Yao, Side

doi:10.1007/s10544-007-9134-7

Cited by 19 publications

(14 citation statements)

References 26 publications

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“…These, as well as other formulations, have significant potential for use in drug delivery in a manner similar to that utilized with photoresponsive/light sensitive nanogels. For instance, nanogel can first be directed to the intended therapeutic site by direct application of a permanent magnetic field 122 , and once accumulated in the target site the nanogels release their therapeutic cargo 122 . Magnetic poly(vinyl pyrrolidone) nanogels have been loaded with Bleomycin A5 Hydrochloride (BLM) and injected into rabbits having a squamous cell carcinoma 123 .…”

Section: Stimulus Responsive Nanogelsmentioning

confidence: 99%

Nanogel carrier design for targeted drug delivery

et al. 2014

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Polymer-based nanogel formulations offer features attractive for drug delivery, including ease of synthesis, controllable swelling and viscoelasticity as well as drug loading and release characteristics, passive and active targeting, and the ability to formulate nanogel carriers that can respond to biological stimuli. These unique features and low toxicity make the nanogels a favorable option for vascular drug targeting. In this review, we address key chemical and biological aspects of nanogel drug carrier design. In particular, we highlight published studies of nanogel design, descriptions of nanogel functional characteristics and their behavior in biological models. These studies form a compendium of information that supports the scientific and clinical rationale for development of this carrier for targeted therapeutic interventions.

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Section: Stimulus Responsive Nanogelsmentioning

confidence: 99%

Nanogel carrier design for targeted drug delivery

et al. 2014

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“…In addition, the shell could prevent the nanoparticle core from probable oxidation and aggregation [91]. In cases of using nanoparticles as the core, nanoparticles could possess high magnetization and superparamagnetic behavior along with low toxic properties due to encapsulating by the protective shell, which may make them of use in biomedical applications.…”

Section: Magnetic-field-sensitive Intelligent Nanocomposite Hydrogelsmentioning

confidence: 99%

Intelligent Nanocomposite Hydrogels

Sirousazar

Kokabi

2012

Intelligent Nanomaterials

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Development of functional engineered materials possessing intelligence has been one of the most challenging tasks in research over the past decade. The term "intelligent material" refers to materials that possess three main functions, including sensing, processing, and actuating by exerting external stimuli. In recent years, intelligent nanocomposite hydrogels (INCHs), the newly born multifunctional materials of the 21 s ' century, have gained the serious attention of the scientific community. INCHs are soft and reinforced nanocomposite hydrogels that respond to various stimuli. They exhibit dramatic changes in their properties, e.g., swelling, network structure, or mechanical strength, in response to small variations in external stimuli such as temperature, pH, magnetic or electric fields, light, and presence of molecules. The main goal of this chapter is to review the basic science and technology of INCHs and the recent advances in this area. Additionally, the fundamental concepts of hydrogels, intelligent hydrogels, and nanocomposite hydrogels will be introduced.

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“…[13]. 10 mg magnetic nanogel was dissolved in 20 mL distilled water and stored at 4℃, and the supernatant was sampled at different intervals to investigate the stability using UV-vis measurement.…”

Section: Characterization Of Poly(pegma) Magnetic Nanogelsmentioning

confidence: 99%

Poly(PEGMA) magnetic nanogels: preparation via photochemical method, characterization and application as drug carrier

Sun

Zhang

Zhu

et al. 2009

Sci. China Ser. B-Chem.

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One-pot synthesis of magnetic nanogels with excellent biocompatibility via the photochemical method is reported in this paper. Poly(PEGMA) modified superparamagnetic nanogels (poly(PEGMA) magnetic nanogels) were synthesized by in-situ polymerization using poly(ethylene glycol) methacrylate (PEGMA) as the monomer and N, N'-methylene-bis-(acrylamide) (MBA) as the cross-linking agent in magnetite aqueous suspension under UV irradiation. The surface functional groups and components of magnetic nanogels were analyzed by Fourier transform infrared spectroscopy (FTIR) and a thermogravimetric analyzer (TGA). The results indicated that the poly(PEGMA) magnetic nanogels were synthesized successfully by coating poly(PEGMA) on the Fe 3 O 4 nanoparticles under UV irradiation, and the Fe 3 O 4 nanoparticles content in this nanogels was above 50 wt%. The morphology, size, zeta-potential and magnetic property were also characterized. The magnetic nanogels had a nearly spherical shape and core-shell structure, the average size in aqueous system measured by photon correlation spectroscopy (PCS) was 68.4 nm, which was much bigger than that in the dry state, the nanogels behaved superparamagnetically with saturated magnetization of 58.6 emu/g, and the zeta-potential was −16.3-−17.3 mV at physiological pH (6.8-7.4) which could help to maintain stability in blood. The preliminary application as drug carrier was made and the doxorubicin-loaded magnetic nanogels had an excellent property in slow-release. The experiment indicated that the magnetic nanogel was an ideal candidate carrier in target drug delivery systems and other biomedical application. magnetic nanogels, photochemical polymerization, poly(ethylene glycol) methacrylate, drug carrier, doxorubicin

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188Re-labeled MPEG-modified superparamagnetic nanogels: preparation and targeting application in rabbits

Cited by 19 publications

References 26 publications

Nanogel carrier design for targeted drug delivery

Nanogel carrier design for targeted drug delivery

Intelligent Nanocomposite Hydrogels

Poly(PEGMA) magnetic nanogels: preparation via photochemical method, characterization and application as drug carrier

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