In vivo ethanol elimination in man, monkey and rat: A lack of relationship between the ethanol metabolism and the hepatic activities of alcohol and aldehyde dyhydrogenases

Chronic Heavy Ethanol Consumption Is Associated with Decreased Platelet Aggregation in Rats

“…Ethanol metabolism in rats was shown to be much faster than in human subjects. Hepatic ethanol-metabolizing activities and the in vivo ethanol elimination rate are quite different in rats and human subjects (Zorzano et al 1990). …”

Non-Human Primate Model for Performance Effects of Ethanol

“…Zorzano (50) found that macaques eliminate ethanol substantially faster than men, even though liver metabolic pathways do not appear dissimilar enough to account for the differences. Winneke (18,47) has pointed out the importance of knowing blood levels (or even better, target organ levels) of a toxicant, because, for example, the toxic effects of lead are quite consistent across several species (rat, monkey, and man) when compared by blood levels; they are very inconsistent when dosages (mg/kg/day) are the basis of comparison.…”

Alcoholism and mental illness: overlapping diseases requiring a renewed focus

“…In other models of alcoholism, animals do not willingly consume alcohol at all, but are rather injected intraperitoneally or subcutaneously, or receive ethanol via gavage or intubation (Girard, Xing, Ward, & Wainwright, 2000;Hartmann et al, 2013;Tran, Cronise, Marino, Jenkins, & Kelly, 2000). Moreover, due to species-specific differences in metabolism and scale, the quantity of alcohol consumed by laboratory animals does not easily translate to realistic quantities consumed by adult humans (Zorzano & Herrera, 1990). For example, in a model of binge drinking in rats, animals consumed doses of alcohol of 5 g/kg body weight just in the first of several doses, administered every 8 hours for four days (Maynard & Leasure, 2013).…”