Chronic Heavy Ethanol Consumption Is Associated with Decreased Platelet Aggregation in Rats

Baysan, Oben; Kaptan, Kürşat; Erınç, Kürşad; Öztaş, Yeşim; Coskun, Tayibe; Kayır, Hakan; Uzun, Mehmet; Uzbay, Tayfun; Beyan, Cenǵiz; Işık, Ersoy

doi:10.1620/tjem.206.85

Cited by 9 publications

(6 citation statements)

References 35 publications

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“…Patients with chronic alcohol misuse admitted to the hospital demonstrated decreased platelet counts compared with nonalcoholic patients, and after 1 week of abstinence, the platelet counts normalized. 9 In vitro studies showed significantly diminished platelet aggregation response 10,12,13,[29][30] and prolonged bleeding times after chronic alcohol ingestion. 13 In our study, chronic alcoholic patients with ethanol infusion did not exhibit preoperatively or postoperatively significant prolonged aPTT or decreased Quick values compared with controls.…”

Section: Discussionmentioning

confidence: 99%

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The Effect of Stress-Reducing, Low-Dose Ethanol Infusion on Frequency of Bleeding Complications in Long-Term Alcoholic Patients Undergoing Major Surgery

Schoenfeld

Heymann

Lau

et al. 2007

The American Surgeon™

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Perioperative low-dose ethanol infusion is a feasible option for stress reduction and prophylaxis of alcoholism-associated complications. Because alcohol has inhibitory effects on hemostasis, our study focused on the effect of perioperative low-dose ethanol infusion on bleeding complications, defined as transfused blood units and reoperations, in alcoholic patients undergoing major surgery. We included 44 long-term alcoholic patients scheduled for tumor resection of the aerodigestive and gastrointestinal tract. Patients were randomly assigned to the ethanol or control group. Ethanol infusion (0.5 g ethanol/kg body weight/24 hours) started before surgery and was continued until the postoperative Day 3. Regarding all patients, there was no statistically significant difference in the amount of transfused blood between the ethanol and control groups. However, the effect of ethanol infusion on bleeding complications depended on the site of surgery. Ethanol infusion resulted in an increased number of transfused blood units in gastrointestinal patients and a decreased number of transfused units in patients undergoing tumor resection of the aero-digestive tract. In conclusion, perioperative ethanol infusion in long-term alcoholic patients with tumor resections of the aerodigestive tract is an option for stress reduction without increased risk for blood transfusion. In contrast, ethanol infusion in patients with tumor resections in the gastrointestinal tract could increase the risk for bleeding complications.

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Section: Discussionmentioning

confidence: 99%

“…7,8 However, previous studies have shown an inhibiting effect of ethanol on hemostasis. Thrombocytopenia, 9 dysfunction in the generation of platelets 10 and plasmatic coagulation factors, 11 and platelet aggregation dysfunction 12,13 can be caused by ethanol or ethanol metabolites.…”

mentioning

confidence: 99%

The Effect of Stress-Reducing, Low-Dose Ethanol Infusion on Frequency of Bleeding Complications in Long-Term Alcoholic Patients Undergoing Major Surgery

Schoenfeld

Heymann

Lau

et al. 2007

The American Surgeon™

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“…Chronic alcohol consumption can affect coagulation by damaging the synthesising capacity of the hepatocytes, both directly and through metabolites [13][14][15][16]. The prolonged clotting times are attributed to a deficiency of vitamin K and a subsequent varying degrees of the production of coagulation factors [17].…”

Section: Discussionmentioning

confidence: 99%

Clotted blood as sign of alcohol intoxication: a retrospective study

et al. 2007

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A total of 138 autopsies performed at the Institute of Legal Medicine of the University of Münster between 1994 and 2006 were subdivided into two groups: (1) 69 asphyxial deaths with a blood alcohol level (BAL) > 1 per thousand and (2) 69 asphyxial deaths with a BAL of 0.00 per thousand. The coagulation state in the central vessels was registered in all cases as fluid, compactly clotted or loosely clotted, and the post-mortem interval was recorded. Histology investigations were performed on the liver to analyze the incidence of hepatic fibrosis/cirrhosis. Fisher's exact test was performed to check for statistical significance. The blood was found to be clotted in 49.3% of the cases of group (1) and in 5.8% of group (2) (p < 0.01). The post-mortem interval did not have any influence on the coagulation state as observed in both groups. Liver fibrosis/cirrhosis was a rare finding detected in three cases in group 1 and in two cases in the control group 2 and, therefore, not relative to our observations. A distinctly positive BAL is often associated with heavy stages of blood coagulation as observed during autopsy. Distinctly positive alcohol concentrations have an influence on the fibrinolytic process and, hence, on the coagulation status.

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“…En el ámbito de plaquetas, estudios desarrollados in vivo, utilizando como modelos ratas, conejos y perros, han demostrado que el consumo moderado de alcohol inhibe la activación plaquetaria y formación de trombos [11][12][13] . Estudios in vitro, utilizando concentraciones bajas de etanol (25 mM), la inhibición de la agregación y secreción plaquetaria involucraría la inhibición de la fosfolipasa A 14,15 .…”

Section: Vino Y Función Cardiovascularunclassified