In vivo estimation of calcium phosphate cements containing chondroitin sulfate in subcutis

Yoshikawa, Masahide; Hayami, S.; Toda, Tadao

doi:10.1016/s0928-4931(02)00023-1

Cited by 8 publications

(7 citation statements)

References 21 publications

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“…In vitro Bioactivity, Bio-Corrosion Resistance and Antibacterial Property of Laser Cladded HA Coatings with Different Content of ZnO on Ti-6Al-4V Substrate After a biomaterial being implanted into the biological system, the first and the foremost event is wetting. A material used in clinical practice must have appropriate wettability 30 . Wettability is perhaps one of the most important factors determining the quantity and quality of adsorbed proteins and the biocompatibility 31,32 .…”

Section: Wettability Investigationmentioning

confidence: 99%

In vitro Bioactivity, Bio-Corrosion Resistance and Antibacterial Property of Laser Cladded HA Coatings with Different Content of ZnO on Ti-6Al-4V Substrate

et al. 2019

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HA/ZnO coatings with varying content of ZnO were fabricated on Ti-6Al-4V substrate to enhance its bioactivity and antibacterial ability. The main phases are identified as CaTiO 3 , Ca 3 (PO 4 ) 2 , ZnTiO 3 and CaO. The coatings with higher ZnO content presented smaller grain size, resulting in a higher surface free energy and better wettability. Consequently, the mineralization of the ZnO/HA coatings, especially for the higher ZnO content samples were improved, indicating better enhanced in vitro bioactivity. The ZnO-HA coated Ti-6Al-4V presented better corrosion resistance than bare Ti-6Al-4V substrate. Furthermore, better corrosion resistance was obtained by increasing ZnO content in the precursor. The antimicrobial ratio of all coatings was approximately 100%, indicating the ZnO doped HA coatings presented excellent antibacterial ability.

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Section: Wettability Investigationmentioning

confidence: 99%

In vitro Bioactivity, Bio-Corrosion Resistance and Antibacterial Property of Laser Cladded HA Coatings with Different Content of ZnO on Ti-6Al-4V Substrate

et al. 2019

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“…A cement for use in clinical practice must have good handling, appropriate setting time, as well as suitable pH and wettability 28. It has been reported that pH during the hardening process will influence tissue reaction to the cement 29.…”

Section: Discussionmentioning

confidence: 99%

In vitro and in vivo evaluation on the bioactivity of ZnO containing nano‐hydroxyapatite/chitosan cement

Zuo

et al. 2009

J Biomedical Materials Res

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A ZnO containing nano-hydroxyapatite/chitosan (n-HA/CS) cement was developed and its bone formation ability was investigated in vitro and in vivo. The physico-chemical properties of the cement were determined in terms of pH variation during and after setting, injectability and wettability. The results indicated that, the pH varied from 7.04 to 7.12 throughout the soaking of the cement in distilled water. The injectability was excellent during the first 4 min, but the cement became less injectable or even not injectable at all after 7 min setting. The static contact angle of the cement against water was 53.5 +/- 2.7 degrees . The results of immersion tests in simulated body fluid (SBF) indicated that the cement exhibited excellent bone-like apatite forming ability. In vivo studies, involving the installation of the cement of tibial-bone defects in rabbit tibia revealed an inflammatory response around the cement at 3 days of implantation. After 4 weeks, the inflammation began to disappear and the cement had bound to the surrounding host bone. Radiological examination also confirmed that the ZnO containing n-HA/CS cement significantly induced new bone formation. These results suggest that the ZnO containing n-HA/CS cement may be beneficial to enhance bone regeneration in osseous defect sites.

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“…Chitosan fibres (Q/19ZSBD-01-95, BD Inc., People's Republic of China) consist of chitosan and bovine collagen and can be completely biodegraded in vivo with the action of enzymes after 70 days. The fibres have an apparent diameter of 200 mm and an apparent density d of 1.75 g/cm 3 . Fibres were incorporated into CPC materials to fabricate a specimen with a fibre volume content P fibre of 5 per cent, which was calculated by the formula…”

Section: Specimen Preparationmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

“…Self-hardened calcium phosphate cement (CPC) possesses great biocompatibility and excellent osteoconductivity and has found a variety of applications, such as dental and craniofacial repairs, in the orthopaedic area [1][2][3][4][5]. However, for the loadbearing region, CPC implants were susceptible to fracture owing to their relatively low mechanical strength, which always caused catastrophic failures in vivo [1][2][3][4][5][6][7]. The incorporation of fibres is commonly used to improve the strength and fracture resistance of materials and various fibres such as carbon fibres, titanium fibres, or resorbable fibres have been widely used to reinforce CPC implants [6][7][8][9][10][11].…”

Section: Introductionmentioning

confidence: 99%

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Mechanical properties and in-vivo performance of calcium phosphate cement—chitosan fibre composite

Lian

et al. 2008

Proc Inst Mech Eng H

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Self-hardened calcium phosphate cement (CPC) sets to form hydroxyapatite and possesses excellent osteoconductivity. However, lack of macroporosity and low strength constrain its application in bone tissue engineering. Recent studies have incorporated various fibres into CPC to improve its mechanical strength. The present approach focused on the reinforcement of CPC with chitosan fibres and then the effects of the fibre structure on the mechanical properties and macrochannels formation characteristics of CPC-fibre composite were investigated. Chitosan fibres of diameter 200 microm were used to fabricate two types of three-dimensional structure, which were then coated with collagen and incorporated into CPC to fabricate CPC-fibre implants with a fibre volume content of 5 per cent. The compressive strength of the CPC-fibre implant was 33 MPa when the strain was 2.4 per cent, which is fourfold higher than that of the CPC control. Nine cylindrical implants including six CPC-fibre implants were implanted in the bone defects of nine dogs and were then post-operatively observed. After 20 weeks in vivo, new callus from the healthy tissue of the defect entirely integrated with the CPC-fibre implant and new bone was formed as the implant degraded. Scanning electronic microscopy images indicated that macrochannels were formed in the CPC-fibre implants with the degradation of fibres, but only micropores with a scale of less than 50 microm could be observed in the CPC control. Briefly, the incorporation of a suitable chitosan-fibre structure into a CPC implant not only could improve its mechanical properties but also facilitated the bone repair process in vivo.

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In vivo estimation of calcium phosphate cements containing chondroitin sulfate in subcutis

Cited by 8 publications

References 21 publications

In vitro Bioactivity, Bio-Corrosion Resistance and Antibacterial Property of Laser Cladded HA Coatings with Different Content of ZnO on Ti-6Al-4V Substrate

In vitro Bioactivity, Bio-Corrosion Resistance and Antibacterial Property of Laser Cladded HA Coatings with Different Content of ZnO on Ti-6Al-4V Substrate

In vitro and in vivo evaluation on the bioactivity of ZnO containing nano‐hydroxyapatite/chitosan cement

Mechanical properties and in-vivo performance of calcium phosphate cement—chitosan fibre composite

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