In vivo Elimination of Clonidine by Continuous Venovenous Hemofiltration in Critically Ill Patients

Oever, Huub L. A. van den; Zeeman, Marieke; Nassikovker, Polina; Bles, Carmen M.A.; Steveninck, Fred A L van; Meijer, Arthur R. de; Kruisdijk-Gerritsen, Arriette; Arbouw, Maurits

doi:10.1159/000505610

Cited by 1 publication

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“…Hypertension means the pressure on the blood vessel wall caused by blood flowing in the blood vessel is higher than the standard value. It is one of the most common cardiovascular diseases and a significant risk factor for stroke, coronary heart disease, and heart failure. − Clonidine is an antihypertensive drug, , inhibiting the central nervous system and lowering the blood pressure. − When the receptors are activated by clonidine, the release of norepinephrine can be reduced, and negative feedback regulation is produced. Therefore, norepinephrine can be considered the biomarker of hypertension .…”

Section: Introductionmentioning

confidence: 99%

Chiral Luminescent Sensor Eu-BTB@d-Carnitine Applied in the Highly Effective Ratiometric Sensing of Curing Drugs and Biomarkers for Diabetes and Hypertension

et al. 2022

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Chiral drugs are of great significance in drug development and life science because one pair of enantiomers has a different combination mode with target biological active sites, leading to a vast difference in physical activity. Metal–organic framework (MOF)-based chiral hybrid materials with specific chiral sites have excellent applications in the highly effective sensing of drug enantiomers. Sitagliptin and clonidine are effective curing drugs for controlling diabetes and hypertension, while insulin and norepinephrine are the biomarkers of these two diseases. Excessive use of sitagliptin and clonidine can cause side effects such as stomach pain, nausea, and headaches. Herein, through post-synthetic strategy, MOF-based chiral hybrid material Eu-BTB@ d -carnitine (H3BTB = 1,3,5-benzenetrisbenzoic acid) was synthesized. Eu-BTB@ d -carnitine has dual emission peaks at 417 and 616 nm when excited at 330 nm. Eu-BTB@ d -carnitine can be applied in luminescent recognition toward sitagliptin and clonidine with high sensitivity and low detection limit (for sitagliptin detection, K sv is 7.43 × 106 [M–1]; for clonidine detection, K sv is 9.09 × 106 [M–1]; limit of detection (LOD) for sitagliptin is 10.21 nM, and LOD of clonidine is 8.34 nM). In addition, Eu-BTB@ d -carnitine can further realize highly sensitive detection of insulin in human fluids with a high K sv (2.08 × 106 [M–1]) and a low LOD (15.48 nM). On the other hand, norepinephrine also can be successfully discriminated by the hybrid luminescent platform of Eu-BTB@ d -carnitine and clonidine with a high K sv value of 4.79 × 106 [M–1] and a low LOD of 8.37 nM. As a result, the chiral hybrid material Eu-BTB@ d -carnitine can be successfully applied in the highly effective ratiometric sensing of curing drugs and biomarkers for diabetes and hypertension.

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