In Vivo Electrochemical Biosensors: Recent Advances in Molecular Design, Electrode Materials, and Electrochemical Devices

Wang, Shidi; Liu, Yuandong; Zhu, Anwei; Tian, Yang

doi:10.1021/acs.analchem.2c04541

Cited by 30 publications

(11 citation statements)

References 175 publications

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“…Incorporating the natural bioselectivity of the biological component, electrochemical biosensors combine the sensitivity of electroanalytical methods with the analytical precision of the chemical component. Once the analyte has been recognized by the biological component of the sensor, a catalytic or binding event will follow, resulting in an electrical signal that is measured by a transducer and will be proportionate to the analyte concentration [ 108 , 109 , 110 , 111 , 112 , 113 ]. Electrochemical biosensors have been widely used in numerous industries, including clinical diagnostics, environmental monitoring, food safety analysis, etc., because of their ease of use, low cost, exceptional stability, and sensitive response [ 6 , 114 ].…”

Section: Nanozyme-based Biosensorsmentioning

confidence: 99%

Nanozymes towards Personalized Diagnostics: A Recent Progress in Biosensing

Kurup

Ahmed

2023

Biosensors

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This review highlights the recent advancements in the field of nanozymes and their applications in the development of point-of-care biosensors. The use of nanozymes as enzyme-mimicking components in biosensing systems has led to improved performance and miniaturization of these sensors. The unique properties of nanozymes, such as high stability, robustness, and surface tunability, make them an attractive alternative to traditional enzymes in biosensing applications. Researchers have explored a wide range of nanomaterials, including metals, metal oxides, and metal–organic frameworks, for the development of nanozyme-based biosensors. Different sensing strategies, such as colorimetric, fluorescent, electrochemical and SERS, have been implemented using nanozymes as signal-producing components. Despite the numerous advantages, there are also challenges associated with nanozyme-based biosensors, including stability and specificity, which need to be addressed for their wider applications. The future of nanozyme-based biosensors looks promising, with the potential to bring a paradigm shift in biomolecular sensing. The development of highly specific, multi-enzyme mimicking nanozymes could lead to the creation of highly sensitive and low-biofouling biosensors. Integration of nanozymes into point-of-care diagnostics promises to revolutionize healthcare by improving patient outcomes and reducing costs while enhancing the accuracy and sensitivity of diagnostic tools.

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Section: Nanozyme-based Biosensorsmentioning

confidence: 99%

Nanozymes towards Personalized Diagnostics: A Recent Progress in Biosensing

Kurup

Ahmed

2023

Biosensors

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“…The design of supramolecular receptors is a way to develop selective sensor devices that respond to specific analytes [ 1 , 2 , 3 , 4 ]. The deposition of a supramolecular receptor on a suitable electrode surface offers the possibility of preparing a selective electrode–solution interface [ 5 ]. An electrochemical sensor detects the interaction between an analyte of interest and the modified electrode through changes in the generated electrochemical signal (e.g., capacitance, charge-transfer resistance, current).…”

Section: Introductionmentioning

confidence: 99%

Voltammetric Detection of Vanillylmandelic Acid and Homovanillic Acid Using Urea-Derivative-Modified Graphite Electrode

Shishkanova

Králík

Synytsya

2023

Sensors

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Vanillylmandelic acid (VMA) and homovanillic acid (HVA) are diagnostic markers of neuroblastoma. The purpose of this study was to understand the reason for the discrimination of structural analogues (VMA and HVA) onto a graphite electrode coated with an electrochemically oxidized urea derivative. Density functional theory calculations (DFT), FTIR spectroscopic measurements, and electrochemical impedance spectroscopic measurements were used in this work. Density functional theory calculations (DFT) were used to identify the most suitable binding sites of the urea derivative and to describe possible differences in its interaction with the studied analytes. The FTIR measurement indicated the enhancement and disappearance of NH vibrations on graphite and platinum surfaces, respectively, that could be connected to a different orientation and thus provide accessibility of the urea moiety for the discrimination of carboxylates. Additionally, the higher the basicity of the anion, the stronger the hydrogen-bonding interaction with –NH-groups of the urea moiety: VMA (pKb = 10.6, KAds = (5.18 ± 1.95) × 105) and HVA (pKb = 9.6, KAds = (4.78 ± 1.58) × 104). The differential pulse voltammetric method was applied to detect VMA and HVA as individual species and interferents. As individual analytes, both HVA and VMA can be detected at a concentration of 1.99 × 10−5 M (RSD ≤ 0.28, recovery 110–115%).

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“…However, most of these techniques are expensive and time-consuming, and require skilled manpower, tedious sample pretreatment, and huge instrumentation setup [ 17 , 18 , 19 , 20 , 21 , 22 , 23 ]. Among them, the electrochemical biosensor is the most preferred technology due to its robustness, simplicity, rapidity, portability, cost-effectiveness, ease of handling, high sensitivity, and selectivity toward target analytes, in addition to reliable and reproducible responses [ 24 , 25 , 26 , 27 , 28 ]. In general, electrochemical sensing was performed in a three-electrode cell system composed of a modified working electrode (WE), reference electrode (RE), and counter electrode (CE).…”

Section: Introductionmentioning

confidence: 99%

Recent Developments in the Design and Fabrication of Electrochemical Biosensors Using Functional Materials and Molecules

Theyagarajan

Kim

2023

Biosensors

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Electrochemical biosensors are superior technologies that are used to detect or sense biologically and environmentally significant analytes in a laboratory environment, or even in the form of portable handheld or wearable electronics. Recently, imprinted and implantable biosensors are emerging as point-of-care devices, which monitor the target analytes in a continuous environment and alert the intended users to anomalies. The stability and performance of the developed biosensor depend on the nature and properties of the electrode material or the platform on which the biosensor is constructed. Therefore, the biosensor platform plays an integral role in the effectiveness of the developed biosensor. Enormous effort has been dedicated to the rational design of the electrode material and to fabrication strategies for improving the performance of developed biosensors. Every year, in the search for multifarious electrode materials, thousands of new biosensor platforms are reported. Moreover, in order to construct an effectual biosensor, the researcher should familiarize themself with the sensible strategies behind electrode fabrication. Thus, we intend to shed light on various strategies and methodologies utilized in the design and fabrication of electrochemical biosensors that facilitate sensitive and selective detection of significant analytes. Furthermore, this review highlights the advantages of various electrode materials and the correlation between immobilized biomolecules and modified surfaces.

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In Vivo Electrochemical Biosensors: Recent Advances in Molecular Design, Electrode Materials, and Electrochemical Devices

Cited by 30 publications

References 175 publications

Nanozymes towards Personalized Diagnostics: A Recent Progress in Biosensing

Nanozymes towards Personalized Diagnostics: A Recent Progress in Biosensing

Voltammetric Detection of Vanillylmandelic Acid and Homovanillic Acid Using Urea-Derivative-Modified Graphite Electrode

Recent Developments in the Design and Fabrication of Electrochemical Biosensors Using Functional Materials and Molecules

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