In vivo efficacy of different extracts of Edelweiss (Leontopodium alpinum Cass.) in animal models

Speroni, Ester; Schwaiger, Stefan; Egger, Philipp; Berger, Anna-Theres; Cervellati, Rinaldo; Govoni, Paolo; Guerra, Maurizio; Stuppner, Hermann

doi:10.1016/j.jep.2005.11.019

Cited by 33 publications

(24 citation statements)

References 15 publications

(15 reference statements)

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“…Natural active principles, endowed with antiinflammatory activity, frequently exhibit antioxidant power; moreover many plant extracts play a therapeutic role interacting with several biosynthetic pathways of inflammation mediators (Speroni et al, 2006). For this reason it seemed of interest to check extracts of Cyclamen for antioxidant capacity, using two different in vitro chemical methods: the Briggs-Rauscher reaction method (Cervellati et al, 2001) and the TEAC assay (Re et al, 1999).…”

Section: Introductionmentioning

confidence: 99%

Analgesic and antiinflammatory activity of Cyclamen repandum S. et S.

Speroni

Cervellati

Costa

et al. 2007

Phytotherapy Research

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According to folk medicine some species belonging to the genus Cyclamen were used for their biological activities. Early investigation of the different species of the genus resulted in the isolation of triterpenic saponins. No phytochemical and biological data are available on C. repandum. As part of a series of phytochemical investigations for bioactive compounds from medicinal plants, Cyclamen repandum S. et S. was investigated. The present study sought to find the antiinflammatory and antinociceptive activities of C. repandum tubers in rats and mice. A preliminary screening was conducted with three different extracts in the tests used, particularly the paw edema and the writhing tests. Subsequently some saponins isolated from the ME extract, the more effective one, have been identified. This paper also describes the results of fractionation and bioassay guided chemical studies. Chemical investigation of the active extract afforded the isolation and characterization of six triterpenic saponins. The possible antiinflammatory and analgesic properties were investigated as the saponin content of the fractions allows to speculate on such aspect.

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Section: Introductionmentioning

confidence: 99%

Analgesic and antiinflammatory activity of Cyclamen repandum S. et S.

Speroni

Cervellati

Costa

et al. 2007

Phytotherapy Research

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“…This in vivo model has been proven to be a useful and reliable tool to study the anti-inflammatory effect of drugs administered per os (Winter et al, 1962;Di Rosa et al, 1971;Ismail et al, 1997). Moreover, our research group has successfully already used this animal model to explore the in vivo anti-inflammatory activity of several extracts from medicinal plants (Speroni et al, 2006(Speroni et al, , 2007a.…”

Section: Discussionmentioning

confidence: 99%

In vivo anti-inflammatory effect of Rosa canina L. extract

Lattanzio

Greco

Carretta

et al. 2011

Journal of Ethnopharmacology

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“…In addition to the outstanding antiinflammatory, antibacterial (Dobner et al 2004) -even with infections (Stuppner, 2000) -and analgesic effects (Speroni et al, 2006) the "Edelweiss" shows a superior property as a scavenger and antioxidant (Schwalger et al, 2005) and preserves so cells from damage (also by molds; (Costa et al, 2009). While Leoligin (Fig.…”

Section: Fig 4 Aloe Veramentioning

confidence: 99%

VITA Intense – Product with Negative Oxidation-reduction Potential (ORP) as Important Quality for Antioxidant and Inhibition Growth of Tumor Cells Effects. Anti Aging Effects

Ignatov¹,

Pesheva²

2018

European Journal of Medicine

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We studied the mathematical model of interaction with water VITA intense of LavaVitae company (Austria). In this report are submitted data about the interaction of VITA intense with water, obtained by non-equilibrium (NES) and differential-equilibrium energy spectrum (DNES) of water. The average energy (∆EH... O) of hydrogen Н…O-bonds among individual molecules H2O after treatment of VITA intense with water measured by NES-and DNES-methods is ∆E=-0.0136±0.0011 eV for VITA intense. This result suggests the restructuring of ∆EH... O values among H2O molecules with a statistically reliable increase of local extremums in DNES-spectra. The research is performed for VITA intense, with study of pH and oxidative reduction potential (ORP). There is review of the effects of the chemical composition of VITA intense -antiinflammatory, antioxidant etc. With methods NES we show the following effects -relaxing effect of nervous system, anti-inflammatory and inhibition of tumor cells. As results of these effects VITA intense has anti aging influence. The base of this influence is anti-inflammatory effect. This article deals with the review of the basic biophysical-biochemical and biological processes underlying the VITA intense. The author is studying their physical-chemical properties and biophysical and biological effects on human organism. Additionally, by using IR, NES, and DNES methods are investigated various samples of water from Bulgarian water springs: the melt water from Glacier Rosenlaui, Swiss Alps, as well as the human blood serum of people with excellent health and cancer patients between 50 and 70 years old. Other experiments were performed on a 1 % (v/v) solution of VITA intense in deionized water. As an estimation factor in NES and DNES was measured the values of the average energy of hydrogen bonds (∆EH...O) among H2O molecules in water samples, as well as a local extremums in the NES and DNES-spectra of various samples of water and the human blood serum at E = -0.1387 eV and λ = 8.95 μm. For a group of people in critical condition of life and patients with malignant tumors the greatest values of local extremums in IR-, DNESspectra were shifted to lower energies relative to the control healthy group. Further we applied this method for calculation of percent distribution of H2O molecules in all studied water samples according to energies of hydrogen bonds ranged from (-0.08 to -0.1387 eV). It was shown that mountain water is among the most important factors for human longevity and human health. The variety of ions (K + , Na + , Ca 2+ , Mg 2+ , Mn 2+ , Fe 2+ , Fe 3+ , Zn 2+ , SO4 2-, Cl -, HCO3 -, CO3 2-), the chemical-physical parameters (pH, electroconductivity) and the decreased content of deuterium in studied water samples renders beneficial effects of these types of water on human health. We are applying the conclusions for the effects of mountain water on human health and longevity as base * Corresponding author E-mail addresses: mbioph@abv.bg (I. Ignatov) European Journal of Medicine, 2018, 6(1) ...

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In vivo efficacy of different extracts of Edelweiss (Leontopodium alpinum Cass.) in animal models

Cited by 33 publications

References 15 publications

Analgesic and antiinflammatory activity of Cyclamen repandum S. et S.

Analgesic and antiinflammatory activity of Cyclamen repandum S. et S.

In vivo anti-inflammatory effect of Rosa canina L. extract

VITA Intense – Product with Negative Oxidation-reduction Potential (ORP) as Important Quality for Antioxidant and Inhibition Growth of Tumor Cells Effects. Anti Aging Effects

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