Analgesic and antiinflammatory activity of Cyclamen repandum S. et S.

Abstract

According to folk medicine some species belonging to the genus Cyclamen were used for their biological activities. Early investigation of the different species of the genus resulted in the isolation of triterpenic saponins. No phytochemical and biological data are available on C. repandum. As part of a series of phytochemical investigations for bioactive compounds from medicinal plants, Cyclamen repandum S. et S. was investigated. The present study sought to find the antiinflammatory and antinociceptive activities of C. repandum tubers in rats and mice. A preliminary screening was conducted with three different extracts in the tests used, particularly the paw edema and the writhing tests. Subsequently some saponins isolated from the ME extract, the more effective one, have been identified. This paper also describes the results of fractionation and bioassay guided chemical studies. Chemical investigation of the active extract afforded the isolation and characterization of six triterpenic saponins. The possible antiinflammatory and analgesic properties were investigated as the saponin content of the fractions allows to speculate on such aspect.

In vitrocytotoxic and anticlastogenic activities of saxifragifolin B and cyclamin isolated fromCyclamen persicumandCyclamen libanoticum

“…The genus Cyclamen L. (Primulaceae) is represented by around 20 wild and cultivated species (Speroni et al, 2007). Three of them, Cyclamen persicum Mill, Cyclamen coum Mill, and Cyclamen libanoticum Hildebr, can be found in Lebanese soils, but only C. libanoticum is endemic of the Lebanese flora.…”

“…Three of them, Cyclamen persicum Mill, Cyclamen coum Mill, and Cyclamen libanoticum Hildebr, can be found in Lebanese soils, but only C. libanoticum is endemic of the Lebanese flora. Cyclamen tubers have been used in the folk medicine for their sedative, purgative, antihelmintic, laxative, and abortive properties (Speroni et al, 2007). Different extracts of Cyclamen tubers were shown to possess cytotoxic, antimicrobial, spermicidal, analgesic, and anti-inflammatory activities (Ç aliş et al, 1997;Dall'Acqua et al, 2010;Kupchan et al, 1967;Mahasneh & El-Oqlah, 1999;Primorac et al, 1985).…”

Evaluation of Antinociceptive and Anti-Inflammatory Activities of a New Triterpene Saponin from Bauhinia variegata Leaves

“…The present study showed the effi cacy of compound 9 in different antinociceptive responses generated by a chemical noxious stimulus produced by acetic acid injections or by a thermal noxious stimulus in the hot plate tests. The anti-infl ammatory and antinociceptive activities of compound 9 may be attributed to the oleane-type triterpene (Speroni et al, 2007).…”

The Cytotoxic Effect of Nasodren Nasal Spray (Cyclamen Europaeum Extract) in L929 Fibroblastic Cell Culture

“…6,9 In vi vo si de ef fects are lo cal and tem po rary be ca u se the pro duct is not ab sor bed or enters the blo ods tre am. [10][11][12] In this study, in vit ro cyto to xic ef fect of a new com mer ci al plant ex tract (Cycla men eu ro pa e um) (Na sod ren na sal spray) was in ves ti ga ted in L929 fib rob last cul tu re. The in vit ro to xic ef fect of the drug se e med to be do se de pen dent and ir re ver sible.…”