Abstract:-The novel synthetic growth hormone-releasing heptapeptide GHRP-is reported to be more potent than growth hormone-releasing hormone (GHRH) in eliciting GH release in vivo in rats and man. However, in ovine pituitary cells in primary culture in a perifusion system, GHRP-1 was 10-fold less active than GHRH. The purpose of this work was to study the effect of GHRP-1 in sheep in vivo. Ovine GH release stimulated by either GHRP-1 or GHRH() -29)NH!, in eight pre-ruminant lambs, was determined. GHRP-was administered … Show more
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