In vivo effects of n-TiO2 on digestive gland and immune function of the marine bivalve Mytilus galloprovincialis

Barmo, Cristina; Ciacci, Caterina; Canonico, Barbara; Fabbri, Rita; Cortese, Katia; Balbi, Teresa; Marcomini, Antonio; Pojana, Giulio; Gallo, Gabriella; Canesi, Laura

doi:10.1016/j.aquatox.2013.01.014

Cited by 178 publications

(106 citation statements)

References 36 publications

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“…Barmo et al (Barmo et al, 2013) have investigated the in vivo effect of nTiO 2 on the M. galloprovincialis digestive gland and reported no morphological differences in the digestive tubules after the exposure to 0.1 mg L À 1 of nTiO 2 -P25 during 4 days, which is in agreement with results from this work. In fact, after 3 days of exposure, scarce or no morphological changes in tissues were observed (Fig.…”

Section: Effects Of CD and N-tio2 In The Digestive Glandsupporting

confidence: 95%

Bioavailability of cadmium and biochemical responses on the freshwater bivalve Corbicula fluminea – the role of TiO2 nanoparticles

Vale

Franco

Diniz

et al. 2014

Ecotoxicology and Environmental Safety

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Section: Effects Of CD and N-tio2 In The Digestive Glandsupporting

confidence: 95%

Bioavailability of cadmium and biochemical responses on the freshwater bivalve Corbicula fluminea – the role of TiO2 nanoparticles

Vale

Franco

Diniz

et al. 2014

Ecotoxicology and Environmental Safety

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“…In contrast, GPx activity was increased in both TiO2NP exposure groups, although induction was highest the low TiO2NP exposure. Similar variable dose-dependent responses in GPx and SOD activities with inductions at exposure to low concentrations of TiO2NP but not at higher exposure concentrations have previously been reported in M. galloprovencialis and abalone (Barmo et al, 2013;Zhu et al, 2011a;Zhu et al, 2011b).…”

Section: Discussionsupporting

confidence: 84%

“…As a consequence they are particularly susceptible to ENP exposure (Canesi et al, 2012). Previous in vivo and in vitro studies have reported adverse effects of TiO2NP on immune system and digestive gland function of M. galloprovincialis (Barmo et al, 2013;Canesi et al, 2010). In the present study we examined oxidative stress responses and genotoxic effects of TiO2NP and B(a)P, a carcinogenic PAH, in single and mixed exposures of these contaminants in the blue mussel M. edulis.…”

Section: Introductionmentioning

confidence: 94%

The impact of TiO2 nanoparticles on uptake and toxicity of benzo(a)pyrene in the blue mussel (Mytilus edulis)

Farkas

Bergum

Nilsen

et al. 2015

Science of The Total Environment

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Nanoparticles are emerging contaminants of concern. Knowledge on their environmental impacts is scarce, especially on their interactive effects with other contaminants. In this study we investigated effects of titanium dioxide nanoparticles (TiO2NP) on the blue mussel (Mytilus edulis) and determined their influence on the bioavailability and toxicity of benzo(a)pyrene (B(a)P), a carcinogenic polyaromatic hydrocarbon (PAH). Blue mussels were exposed to either TiO2NP (0.2 and 2.0 mg L -1 ) or B(a)P (20 µg L -1 ) and to the respective combinations of these two compounds. Aqueous contaminant concentrations, the uptake of Ti and B(a)P into mussel soft tissue, effects on oxidative stress and chromosomal damage were analyzed. The uncoated TiO2NP agglomerated rapidly in the seawater. The presence of TiO2NP significantly reduced the bioavailability of B(a)P, shown by lowered B(a)P concentrations in exposure tanks and in mussel tissue. The activities of antioxidant enzymes superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx) were impacted by the various exposures regimes, indicating oxidative stress in the contaminant exposure groups. While SOD activity was increased only in the 0.2TiO2NP exposure group, CAT activity was enhanced in both combined exposure groups.The GPx activity was increased only in the groups exposed to the two single compounds. In hemocytes, increased chromosomal damage was detected in mussels exposed to the single compounds, which was further increased after exposure to the combination of compounds. In this study we show that the presence of TiO2NP in the exposure system reduced B(a)P uptake in blue mussels. However, since most biomarker responses did not decrease despite lower B(a)P uptake in combined exposures, the results suggest that TiO2NP can act as additional stressor, or potentially alters B(a)P toxicity by activation.

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“…Similar results were found in this study for the mussels exposed to similar nano-TiO 2 concentrations (0-10 mg L −1 ). TiO 2 NPs caused inflammatory responses, oxidative stress, and histopathological alterations in different animal species and to some degree contributed to the functional disturbance of lysosome (Federici et al, 2007;Jemec et al, 2008;Canesi et al, 2012;Barmo et al, 2013). In the present study, lysosomal content was significantly reduced by low pH and high nano-TiO 2 during the exposure period, suggesting that immunity of mussels was impaired by NPs under acidification.…”

Section: Discussionmentioning

confidence: 51%

Hemocyte responses of the thick shell mussel Mytilus coruscus exposed to nano-TiO 2 and seawater acidification

et al. 2016

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In vivo effects of n-TiO2 on digestive gland and immune function of the marine bivalve Mytilus galloprovincialis

Cited by 178 publications

References 36 publications

Bioavailability of cadmium and biochemical responses on the freshwater bivalve Corbicula fluminea – the role of TiO2 nanoparticles

Bioavailability of cadmium and biochemical responses on the freshwater bivalve Corbicula fluminea – the role of TiO2 nanoparticles

The impact of TiO2 nanoparticles on uptake and toxicity of benzo(a)pyrene in the blue mussel (Mytilus edulis)

Hemocyte responses of the thick shell mussel Mytilus coruscus exposed to nano-TiO 2 and seawater acidification

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