Hemocyte responses of the thick shell mussel Mytilus coruscus exposed to nano-TiO 2 and seawater acidification

Huang, Xizhi; Lin, Daohui; Ning, Ke; Sui, Yanming; Hu, Menghong; Lu, Wei; Wang, Youji

doi:10.1016/j.aquatox.2016.09.008

Cited by 67 publications

(22 citation statements)

References 70 publications

(93 reference statements)

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“…Hence, in the present study, some physiological functions, such as clearance, respiration and absorption were all impaired when mussels were exposed to nano-TiO 2 , especially the combined treatment. The CO 2 -induced low pH in seawater could change the physiochemical properties of nano-TiO 2 and lead to a slightly greater aggregation of nano-TiO 2 66. In the present study, although the exposed nano-TiO 2 concentration under low pH was lower than under normal pH, no significant difference was found in each nano-TiO 2 concentration (Supplementary Table 1).…”

Section: Discussioncontrasting

confidence: 53%

“…M. edulis increased oxyradical production and antioxidant enzyme activities when they were exposed to nano-TiO 2 1115. In our previous study, the hemocyte functions of M. coruscus exposed to nano-TiO 2 and high pCO 2 were impaired associated with an increase of ROS production, indicating an oxidative stress and fitness impairment66. Hence, in the present study, some physiological functions, such as clearance, respiration and absorption were all impaired when mussels were exposed to nano-TiO 2 , especially the combined treatment.…”

Section: Discussionmentioning

confidence: 71%

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CO2-induced pH reduction increases physiological toxicity of nano-TiO2 in the mussel Mytilus coruscus

Lin

Shang

et al. 2017

Sci Rep

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The increasing usage of nanoparticles has caused their considerable release into the aquatic environment. Meanwhile, anthropogenic CO2 emissions have caused a reduction of seawater pH. However, their combined effects on marine species have not been experimentally evaluated. This study estimated the physiological toxicity of nano-TiO2 in the mussel Mytilus coruscus under high pCO2 (2500–2600 μatm). We found that respiration rate (RR), food absorption efficiency (AE), clearance rate (CR), scope for growth (SFG) and O:N ratio were significantly reduced by nano-TiO2, whereas faecal organic weight rate and ammonia excretion rate (ER) were increased under nano-TiO2 conditions. High pCO2 exerted lower effects on CR, RR, ER and O:N ratio than nano-TiO2. Despite this, significant interactions of CO2-induced pH change and nano-TiO2 were found in RR, ER and O:N ratio. PCA showed close relationships among most test parameters, i.e., RR, CR, AE, SFG and O:N ratio. The normal physiological responses were strongly correlated to a positive SFG with normal pH and no/low nano-TiO2 conditions. Our results indicate that physiological functions of M. coruscus are more severely impaired by the combination of nano-TiO2 and high pCO2.

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Section: Discussioncontrasting

confidence: 53%

Section: Discussionmentioning

confidence: 71%

CO2-induced pH reduction increases physiological toxicity of nano-TiO2 in the mussel Mytilus coruscus

Lin

Shang

et al. 2017

Sci Rep

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“…[86] DOM (such as humic acids) can attenuate the sunlight-induced generation of ROS via a ROS quenching mechanism and thus diminish the oxidative stress in the presence of photocatalytic nano-TiO 2 . [85,91] Hypoxia and low pH can enhance the toxic effects of nano-TiO 2 in aquatic organisms as was shown in bivalves, [92][93][94] whereas the interactions of nano-TiO 2 with dissolved metals are more variable. [94][95][96][97] Nano-TiO 2 can also serve as a carrier for other environmental pollutants including divalent metals such as Cu 2+ , Zn 2+ , Pb 2+ , and Cd 2+ and metalloids such as arsenic (As).…”

Section: The Sources and Fate Of Nano-tio 2 In The Aquatic Environmentmentioning

confidence: 96%

Rethinking Nano‐TiO₂ Safety: Overview of Toxic Effects in Humans and Aquatic Animals

Luo

Xie

et al. 2020

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Titanium dioxide nanoparticles (nano‐TiO2) are widely used in consumer products, raising environmental and health concerns. An overview of the toxic effects of nano‐TiO2 on human and environmental health is provided. A meta‐analysis is conducted to analyze the toxicity of nano‐TiO2 to the liver, circulatory system, and DNA in humans. To assess the environmental impacts of nano‐TiO2, aquatic environments that receive high nano‐TiO2 inputs are focused on, and the toxicity of nano‐TiO2 to aquatic organisms is discussed with regard to the present and predicted environmental concentrations. Genotoxicity, damage to membranes, inflammation and oxidative stress emerge as the main mechanisms of nano‐TiO2 toxicity. Furthermore, nano‐TiO2 can bind with free radicals and signal molecules, and interfere with the biochemical reactions on plasmalemma. At the higher organizational level, nano‐TiO2 toxicity is manifested as the negative effects on fitness‐related organismal traits including feeding, reproduction and immunity in aquatic organisms. Bibliometric analysis reveals two major research hot spots including the molecular mechanisms of toxicity of nano‐TiO2 and the combined effects of nano‐TiO2 and other environmental factors such as light and pH. The possible measures to reduce the harmful effects of nano‐TiO2 on humans and non‐target organisms has emerged as an underexplored topic requiring further investigation.

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“…A weakened hemocyte with a reduced phagocytic activity can have profound implications on the capacity of the mussels to fight infections, as hemocytes are among the most important mechanisms to prevent bacterial proliferation in the organism . Nano‐TiO 2 has been found to be immune compromising in Mytilus coruscus . Exposure to nano‐TiO 2 reduced phagocytosis, total hemocyte count, and increased hemocyte mortality and ROS production with some of these effects lasting even after a 7‐day recovery period .…”

Section: Discussionmentioning

confidence: 99%

“…Nano‐TiO 2 has been found to be immune compromising in Mytilus coruscus . Exposure to nano‐TiO 2 reduced phagocytosis, total hemocyte count, and increased hemocyte mortality and ROS production with some of these effects lasting even after a 7‐day recovery period . This implies that nanoparticles could have long lasting effects on Mytilus and other bivalve species.…”

Section: Discussionmentioning

confidence: 99%

Effects of soluble copper and copper oxide nanoparticle exposure on the immune system of mussels, Mytilus galloprovincialis

Torres‐Duarte

Hutton

Vines

et al. 2018

Environmental Toxicology

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Hemocyte responses of the thick shell mussel Mytilus coruscus exposed to nano-TiO 2 and seawater acidification

Cited by 67 publications

References 70 publications

CO2-induced pH reduction increases physiological toxicity of nano-TiO2 in the mussel Mytilus coruscus

CO2-induced pH reduction increases physiological toxicity of nano-TiO2 in the mussel Mytilus coruscus

Rethinking Nano‐TiO₂ Safety: Overview of Toxic Effects in Humans and Aquatic Animals

Effects of soluble copper and copper oxide nanoparticle exposure on the immune system of mussels, Mytilus galloprovincialis

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Hemocyte responses of the thick shell mussel Mytilus coruscus exposed to nano-TiO 2 and seawater acidification

Cited by 67 publications

References 70 publications

CO2-induced pH reduction increases physiological toxicity of nano-TiO2 in the mussel Mytilus coruscus

CO2-induced pH reduction increases physiological toxicity of nano-TiO2 in the mussel Mytilus coruscus

Rethinking Nano‐TiO2 Safety: Overview of Toxic Effects in Humans and Aquatic Animals

Effects of soluble copper and copper oxide nanoparticle exposure on the immune system of mussels, Mytilus galloprovincialis

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Rethinking Nano‐TiO₂ Safety: Overview of Toxic Effects in Humans and Aquatic Animals