In vivo effect of deoxynivalenol (DON) naturally contaminated feed on porcine reproductive and respiratory syndrome virus (PRRSV) infection

Savard, Christian; Pinilla, Vicente; Provost, Chantale; Gagnon, Carl A.; Chorfi, Younès

doi:10.1016/j.vetmic.2014.10.019

Cited by 20 publications

(28 citation statements)

References 35 publications

(4 reference statements)

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“…The present results show that diets contaminated with DON interact with PRRS attenuated vaccine and increases the loss of weight gain after vaccination. Similar effects have been previously observed after experimental infection with PRRSV in pigs fed DON naturally contaminated diet [14].…”

Section: Discussionsupporting

confidence: 87%

“…Indeed, contamination of feed with DON has been previously implicated in vaccine failure due to the effects of DON on the immune system [12,35,36]. Moreover, ingestion of DON naturally contaminated feed have been previously shown to decrease PRRSV-specific antibody titers after experimental PRRSV infection [14]. In the case of PRRS MLV, live PRRSV replication is required to provide immunological protection against PRRSV infection [37].…”

Section: Discussionmentioning

confidence: 99%

“…The experimental diets used in this study were formulated according to the energy and amino acid requirements for piglets as previously described [14]. Dietary contents of mycotoxins were analyzed in the final diet through ultra-performance liquid chromatography/electrospray ionization tandem mass spectrometry as previously described [14].…”

Section: Experimental Dietsmentioning

confidence: 99%

“…Nonetheless, other studies reported an increase of specific-IgA accompanied with a decrease of specific IgG and cytokines activation following immunization with ovalbumin in DON-fed piglets [12,13]. More recently, DON naturally contaminated diet has also been shown to decrease porcine reproductive and respiratory syndrome (PRRS) virus-specific antibody responses following experimental infection [14].…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Deoxynivalenol (DON) naturally contaminated feed impairs the immune response induced by porcine reproductive and respiratory syndrome virus (PRRSV) live attenuated vaccine

Savard

Gagnon

Chorfi

2015

Vaccine

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Section: Discussionsupporting

confidence: 87%

Section: Discussionmentioning

confidence: 99%

Section: Experimental Dietsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Deoxynivalenol (DON) naturally contaminated feed impairs the immune response induced by porcine reproductive and respiratory syndrome virus (PRRSV) live attenuated vaccine

Savard

Gagnon

Chorfi

2015

Vaccine

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“…In presence of porcine circovirus type 2 (PCV2) virus, DON increases the severity of the viral infection, and in presence of the porcine reproductive and respiratory syndrome virus (PRRSV) it also increases the infection with more tissue lesions induced ( Savard et al., 2014 , Savard et al., 2015b ). During a bacterial infection, DON enhances the inflammatory reaction with an increased production of pro-inflammatory cytokines ( Vandenbroucke et al., 2011 ).…”

Section: Consequence Of Mycotoxin Induced Immunomodulation For Pig Hementioning

confidence: 99%

Impact of mycotoxin on immune response and consequences for pig health

2016

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Mycotoxins are fungal secondary metabolites detected in many agricultural commodities, especially cereals. Due to their high consumption of cereals, pigs are exposed to these toxins. In the European Union, regulations and/or recommendations exist in pig feed for aflatoxins, ochratoxin A, fumonisins, zearalenone, and trichothecenes, deoxynivalenol and T-2 toxin. These mycotoxins have different toxic effects, but they all target the immune system. They have immunostimulatory or immunosuppressive effects depending on the toxin, the concentration and the parameter investigated. The immune system is primarily responsible for defense against invading organisms. The consequences of the ingestion of mycotoxin-contaminated feed are an increased susceptibility to infectious diseases, a reactivation of chronic infection and a decreased vaccine efficacy. In this review we summarized the data available on the effect of mycotoxins on the immune system and the consequences for pig health.

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Trichothecenes: immunomodulatory effects, mechanisms, and anti-cancer potential

Wang

Nepovimová

et al. 2017

Arch Toxicol

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Paradoxically, trichothecenes have both immunosuppressive and immunostimulatory effects. The underlying mechanisms have not been fully explored. Early studies show that dose, exposure timing, and the time at which immune function is assessed influence whether trichothecenes act in an immunosuppressive or immunostimulatory fashion. Recent studies suggest that the immunomodulatory function of trichothecenes is also actively shaped by competing cell-survival and death-signaling pathways. Autophagy may also promote trichothecene immunosuppression, although the mechanism may be complicated. Moreover, trichothecenes may generate an "immune evasion" milieu that allows pathogens to escape host and vaccine immune defenses. Some trichothecenes, especially macrocyclic trichothecenes, also potently kill cancer cells. T-2 toxin conjugated with anti-cancer monoclonal antibodies significantly suppresses the growth of thymoma EL-4 cells and colon cancer cells. The type B trichothecene diacetoxyscirpenol specifically inhibits the tumor-promoting factor HIF-1 in cancer cells under hypoxic conditions. Trichothecin markedly inhibits the growth of multiple cancer cells with constitutively activated NF-κB. The type D macrocyclic toxin Verrucarin A is also a promising therapeutic candidate for leukemia, breast cancer, prostate cancer, and pancreatic cancer. The anti-cancer activities of trichothecenes have not been comprehensively summarized. Here, we first summarize the data on the immunomodulatory effects of trichothecenes and discuss recent studies that shed light on the underlying cellular and molecular mechanisms. These mechanisms include autophagy and major signaling pathways and their crosstalk. Second, the anti-cancer potential of trichothecenes and the underlying mechanisms will be discussed. We hope that this review will show how trichothecene bioactivities can be exploited to generate therapies against pathogens and cancer.

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In vivo effect of deoxynivalenol (DON) naturally contaminated feed on porcine reproductive and respiratory syndrome virus (PRRSV) infection

Cited by 20 publications

References 35 publications

Deoxynivalenol (DON) naturally contaminated feed impairs the immune response induced by porcine reproductive and respiratory syndrome virus (PRRSV) live attenuated vaccine

Deoxynivalenol (DON) naturally contaminated feed impairs the immune response induced by porcine reproductive and respiratory syndrome virus (PRRSV) live attenuated vaccine

Impact of mycotoxin on immune response and consequences for pig health

Trichothecenes: immunomodulatory effects, mechanisms, and anti-cancer potential

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