In vivo Effect of Cassava Flakes Mixed with Euphorbia heterophylla against Salmonella typhi

Omoya, F. O.; Momoh, A. O.; Olaifa, O

doi:10.9734/ejmp/2015/8979

Cited by 2 publications

(2 citation statements)

References 5 publications

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“…The basis for selection of doses involved using a starting dose that was 1/40 th of the dose (2000 mg/kg) associated with liver toxicity in a previous acute toxicity study (Wellington et al, 2020) and using subsequent doses (100, 200 and 400 mg/kg/day). The doses used in this study also covered the range of doses (100-300 mg/kg) reported to have biological activities from previous efficacy studies (Falodun et al, 2006;Annapurna and Hatware, 2014;Omoya et al, 2015). This creates more awareness on the side effects of the extract particularly in pregnant women using it for other therapeutic purposes.…”

Section: Discussionmentioning

confidence: 99%

Uterine Contractile Activity and Abortifacient Effect of the Aqueous Extract of Euphorbia heterophylla L. Leaves in Albino Rats

Elemo¹,

Akinyede²,

Oreagba³

et al. 2022

Pharmacol Toxicol Nat Med

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Background and Purpose: Euphorbia heterophylla Linn. (Euphorbiaceae) is a promising medicinal plant used as an oxytocic in folkloric medicine. The study investigated the uterotonic and abortifacient effects of the aqueous leaf extract of Euphorbia heterophylla (AEEH). Methods: GC-MS analysis of AEEH was done. In vitro experiment on the contractile activity of AEEH was conducted on the uterus of nulliparous female Sprague Dawley rats using an isolated organ bath. The abortifacient activity of the extract was determined in pregnant rats orally administered 50, 100, 200, and 400 mg/kg AEEH for five consecutive days. Results: GC-MS analysis of AEEH revealed high amounts of 1-butanol 3-methyl acetate, benzofuran,2,3-dihydro-, 2-methoxy-4-vinyl phenol, and sucrose. Some of the classes of compounds identified in the extract such as phenols, terpenoids, fatty acids, aldehydes, steroid, and glucoside have been associated with uterotonic and abortifacient properties. The extract (0.125-4 mg/mL) was able to enhance the contractile activity of uterine smooth muscles (EC50 = 3.39 × 10-1 mg/mL) similar to oxytocin (EC50 = 3.99 × 10-4 mg/mL) and acetylcholine (EC50=2.68 × 10-4 mg/mL). Pre-treatment with salbutamol, indomethacin, and stimulation in a calcium-deprived medium significantly (P<0.0001) reduced uterine contractions induced by cumulative concentrations of the aqueous extract. However, there was no significant change in uterine contraction in tissues pre-treated with atropine. The aqueous extract induced abortion in 50%, and 83.33% of the animals at 200, and 400 mg/kg respectively when orally administered to pregnant rats for five days. Conclusions: This study demonstrates the uterotonic and abortifacient effects of AEEH and supports the ethnomedicinal use of the plant as an oxytocic.

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Section: Discussionmentioning

confidence: 99%

Uterine Contractile Activity and Abortifacient Effect of the Aqueous Extract of Euphorbia heterophylla L. Leaves in Albino Rats

Elemo¹,

Akinyede²,

Oreagba³

et al. 2022

Pharmacol Toxicol Nat Med

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“…In the US, a number of medicinal plants have been documented as important source of bioactive compounds (Balunas and Kinghorn, 2005). As reported by Ogunnusi and Oso (2017) and Omoya et al (2015), Euphorbia heterophylla erect and 20-200 cm in height (depending on growing conditions). It belongs to the family of Euphorbiaceae and has been identified as plants widely used in traditional medicine in various parts of Africa and are used in the treatment of skin infections, wart, respiratory tract infection, tumors and diseases of viral origin.…”

Section: Introductionmentioning

confidence: 93%

Phytochemical screening and antibacterial susceptibility of whole plant of Euphorbia heterophylla crude extracts against selected bacteria pathogens

Oloninefa¹,

Abalaka²,

Daniyan³

et al. 2018

Bayero J. Pure App. Sci.

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In vivo Effect of Cassava Flakes Mixed with Euphorbia heterophylla against Salmonella typhi

Cited by 2 publications

References 5 publications

Uterine Contractile Activity and Abortifacient Effect of the Aqueous Extract of Euphorbia heterophylla L. Leaves in Albino Rats

Uterine Contractile Activity and Abortifacient Effect of the Aqueous Extract of Euphorbia heterophylla L. Leaves in Albino Rats

Phytochemical screening and antibacterial susceptibility of whole plant of Euphorbia heterophylla crude extracts against selected bacteria pathogens

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