In vivo differentiation of two vessel wall layers in lower extremity peripheral vein bypass grafts: Application of high‐resolution inner‐volume black blood 3D FSE

Mitsouras, Dimitris; Owens, Christopher D.; Conte, Michael S.; Ersoy, Hale; Creager, Mark A.; Rybicki, Frank J.; Mulkern, Robert V.

doi:10.1002/mrm.22037

Cited by 12 publications

(21 citation statements)

References 39 publications

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“…Regarding T1- versus T2-weighted lumen area differences, the lumen is on average 0.4 ± 0.9 mm 2 (95%CI: 0–0.9 mm 2 ) larger on T1-weighted images. This was not statistically significant, apparently contradicting earlier work [37] that studied a smaller population imaged at only 6 months after implantation. The earlier study found a statistically significant difference of 0.8 ± 0.6 mm 2 (95% CI 0.7–0.9 mm 2 ).…”

Section: Discussioncontrasting

confidence: 99%

“…Seven (47%) patients had coronary artery disease, 8 (53%) had diabetes mellitus, and 13 (87%) had hypertension. Four of the 7 patients imaged 6 months after implantation have been previously reported [37]. …”

Section: Methodsmentioning

confidence: 99%

“…The primary hypothesis is that there is no statistical difference between graft lumen area measured from T1-weighted images, fat suppressed T2-weighted images, or gray scale ultrasound. The 1.5T MR approach is a multi-contrast double inversion recovery (DIR) black-blood [5] three-dimensional high sampling efficiency [33] inner-volume [34] FSE protocol (3D IV-FSE) [10, 35–37]. The secondary hypothesis is that the wall area measured on T1-weighted images is greater than the area measured on T2-weighted images at three distinct time points between 1 and 12 months after implantation, and independent of cardiovascular imager performing the measurements.…”

Section: Introductionmentioning

confidence: 99%

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Multi-contrast high spatial resolution black blood inner volume three-dimensional fast spin echo MR imaging in peripheral vein bypass grafts

Rybicki

Mitsouras

Owens

et al. 2010

Int J Cardiovasc Imaging

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The purpose of this study is to primarily evaluate the lumen area and secondarily evaluate wall area measurements of in vivo lower extremity peripheral vein bypass grafts patients using high spatial resolution, limited field of view, cardiac gated, black blood inner volume three-dimensional fast spin echo MRI. Fifteen LE-PVBG patients prospectively underwent ultrasound followed by T1-weighted and T2-weighted magnetic resonance (MR) imaging. Lumen and vessel wall areas were measured by direct planimetry. For graft lumen areas, T1- and T2-weighted measurements were compared with ultrasound. For vessel wall areas, differences between T1-and T2-weighted measurements were evaluated. There was no significant difference between ultrasound and MR lumen measurements, reflecting minimal MR blood suppression artifact. Graft wall area measured from T1-weighted images was significantly larger than that measured from T2-weighted images (P < 0.001). The mean of the ratio of T1-versus T2-weighted vessel wall areas was 1.59 (95% CI: 1.48–1.69). The larger wall area measured on T1-weighted images was due to a significantly larger outer vessel wall boundary. Very high spatial resolution LE-PVBG vessel wall MR imaging can be performed in vivo, enabling accurate measurements of lumen and vessel wall areas and discerning differences in those measures between different tissue contrast weightings. Vessel wall area differences suggest that LE-PVBG vessel wall tissues produce distinct signal characteristics under T1 and T2 MR contrast weightings.

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Section: Discussioncontrasting

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Multi-contrast high spatial resolution black blood inner volume three-dimensional fast spin echo MR imaging in peripheral vein bypass grafts

Rybicki

Mitsouras

Owens

et al. 2010

Int J Cardiovasc Imaging

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“…4g; channel border marked with arrows). To better visualize the 3D structure of scaffolds and channels, adoption of magnetic resonance (MR) microscopy (Mitsouras et al, 2009), a type of magnetic resonance imaging (MRI), may provide a practical solution (imaging will take less than an hour) of the entire scaffold crosssection. Scanning electron microscopy (SEM) at low magnification may also be conducive to visualize the cross-section of the constructed channel structure.…”

Section: Measurement Of Gelatin Droplet Volume and Channel Widthmentioning

confidence: 99%

On‐demand three‐dimensional freeform fabrication of multi‐layered hydrogel scaffold with fluidic channels

Lee

Polio

et al. 2010

Biotech & Bioengineering

251

147

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One of the challenges in tissue engineering is to provide adequate supplies of oxygen and nutrients to cells within the engineered tissue construct. Soft-lithographic techniques have allowed the generation of hydrogel scaffolds containing a network of fluidic channels, but at the cost of complicated and often time-consuming manufacturing steps. We report a three-dimensional (3D) direct printing technique to construct hydrogel scaffolds containing fluidic channels. Cells can also be printed on to and embedded in the scaffold with this technique. Collagen hydrogel precursor was printed and subsequently crosslinked via nebulized sodium bicarbonate solution. A heated gelatin solution, which served as a sacrificial element for the fluidic channels, was printed between the collagen layers. The process was repeated layer-by-layer to form a 3D hydrogel block. The printed hydrogel block was heated to 378C, which allowed the gelatin to be selectively liquefied and drained, generating a hollow channel within the collagen scaffold. The dermal fibroblasts grown in a scaffold containing fluidic channels showed significantly elevated cell viability compared to the ones without any channels. The on-demand capability to print fluidic channel structures and cells in a 3D hydrogel scaffold offers flexibility in generating perfusable 3D artificial tissue composites.

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“…For suspected complications, specialized imaging such as diffusion-weighted sequences for allograft function 53 and high-resolution vessel wall sequences 54,55 for rejection can be performed. These can be complementary to 3D high-spatial-resolution MR angiography and time-resolved sequences for arterial and venous separation.…”

Section: Future Directionsmentioning

confidence: 99%

CT Angiography for Surgical Planning in Face Transplantation Candidates

Soga

Pomahac

Wake

et al. 2012

AJNR Am J Neuroradiol

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SUMMARY:Facial allotransplantation replaces missing facial structures with anatomically identical tissues, providing desired functional, esthetic, and psychosocial benefits far superior to those of conventional methods. On the basis of very encouraging initial results, it is likely that more procedures will be performed in the near future. Typical candidates have extremely complex vascular anatomy due to severe injury and/or multiple prior reconstructive attempts; thus, each procedure is uniquely determined by the defects and vascular anatomy of the candidate. We detail CT angiography vascular mapping, noting the clinical relevance of the imaging, the angiosome concept and noninvasive delineation of the key vessels, and current controversies related to the vascular anastomoses.

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In vivo differentiation of two vessel wall layers in lower extremity peripheral vein bypass grafts: Application of high‐resolution inner‐volume black blood 3D FSE

Cited by 12 publications

References 39 publications

Multi-contrast high spatial resolution black blood inner volume three-dimensional fast spin echo MR imaging in peripheral vein bypass grafts

Multi-contrast high spatial resolution black blood inner volume three-dimensional fast spin echo MR imaging in peripheral vein bypass grafts

On‐demand three‐dimensional freeform fabrication of multi‐layered hydrogel scaffold with fluidic channels

CT Angiography for Surgical Planning in Face Transplantation Candidates

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