In Vivo Determination of Tetrahydrobiop- terin and Monoamine Neurotransmitters in Rat Brain by Liquid Chromatography with a Nano Crystalline Mn-Doped Lead Dioxide Film Modified Electrode

Zhang, Wen; Wan, Fangli; Gu, Jianhong; Ai, Shiyun; Ye, Jun; Yamamoto, Katsunobu; Jin, Litong

doi:10.1365/s10337-004-0313-x

Cited by 5 publications

(2 citation statements)

References 31 publications

(39 reference statements)

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“…[96, 97] A similar approach was used to develop methods for monitoring the response of catecholamines to treatment with GABA[98] or tetrahydrobiopterin, a catecholamine synthesis cofactor. [99]…”

Section: Monoaminesmentioning

confidence: 99%

Review of recent advances in analytical techniques for the determination of neurotransmitters

Perry

Kennedy

2009

Analytica Chimica Acta

329

221

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Methods and advances for monitoring neurotransmitters in vivo or for tissue analysis of neurotransmitters over the last five years are reviewed. The review is organized primarily by neurotransmitter type. Transmitter and related compounds may be monitored by either in vivo sampling coupled to analytical methods or implanted sensors. Sampling is primarily performed using microdialysis, but low-flow push-pull perfusion may offer advantages of spatial resolution while minimizing the tissue disruption associated with higher flow rates. Analytical techniques coupled to these sampling methods include liquid chromatography, capillary electrophoresis, enzyme assays, sensors, and mass spectrometry. Methods for the detection of amino acid, monoamine, neuropeptide, acetylcholine, nucleoside, and soluable gas neurotransmitters have been developed and improved upon. Advances in the speed and sensitivity of these methods have enabled improvements in temporal resolution and increased the number of compounds detectable. Similar advances have enabled improved detection at tissue samples, with a substantial emphasis on single cell and other small samples. Sensors provide excellent temporal and spatial resolution for in vivo monitoring. Advances in application to catecholamines, indoleamines, and amino acids have been prominent. Improvements in stability, sensitivity, and selectivity of the sensors have been of paramount interest.

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Section: Monoaminesmentioning

confidence: 99%

Review of recent advances in analytical techniques for the determination of neurotransmitters

Perry

Kennedy

2009

Analytica Chimica Acta

329

221

View full text Add to dashboard Cite

show abstract

“…The determination of monoamine neurotransmitters have been carried out by using spectrophotometer [40], fluorescence [41], chemical luminescence [42], pseudopolarography [43], voltammetry [44], capillary electrophoresis [45]. High performance liquid chromatography (HPLC) with electrochemical detection is most often used for the analysis of catecholamines and their metabolites [46][47][48]35]. The detection of neurotransmitters and their metabolites by electrochemical methods have attracted great interests because of their simplicity, rapidness and high sensitivity, the ability of sensing neurotransmitters in living organisms and in vivo real time analysis [49].…”

Section: Introductionmentioning

confidence: 99%