In vivo detection of high-risk coronary plaques by radiofrequency intravascular ultrasound and cardiovascular outcome: results of the ATHEROREMO-IVUS study

Cheng, Jin M.; García‐García, Héctor M.; Boer, Sanneke P.M. de; Kardys, Isabella; Heo, Jung Ho; Akkerhuis, K. Martijn; Oemrawsingh, Rohit M.; Domburg, Ron T. van; Ligthart, Jürgen; Witberg, Karen; Regar, Evelyn; Serruys, Patrick W.; Geuns, Robert‐Jan van; Boersma, Eric

doi:10.1093/eurheartj/eht484

Cited by 324 publications

(214 citation statements)

References 24 publications

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“…Previous studies using invasive techniques [34][35][36][37] have identified high-risk features such as thin-cap, low residual lumen area, and spotty calcification as the hallmark of high-risk plaques. These high-risk plaques identified by either IVUS or OCT were also associated with adverse clinical outcomes.…”

Section: Discussionmentioning

confidence: 99%

Rationale and design of the Progression of AtheRosclerotic PlAque DetermIned by Computed TomoGraphic Angiography IMaging (PARADIGM) registry: A comprehensive exploration of plaque progression and its impact on clinical outcomes from a multicenter serial coronary computed tomographic angiography study

Lee

Chang

Rizvi

et al. 2016

American Heart Journal

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Section: Discussionmentioning

confidence: 99%

Rationale and design of the Progression of AtheRosclerotic PlAque DetermIned by Computed TomoGraphic Angiography IMaging (PARADIGM) registry: A comprehensive exploration of plaque progression and its impact on clinical outcomes from a multicenter serial coronary computed tomographic angiography study

Lee

Chang

Rizvi

et al. 2016

American Heart Journal

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“…Angioscopic, IVUS, and NIRS-based studies have shown that plaque imaging can provide useful prognostic information [142][143][144][145]. However, the above studies included a small number of patients and therefore, the number of events reported was too small to allow us to examine the additive predictive value of intravascular imaging over clinical or angiographic variables.…”

Section: Expert Commentarymentioning

confidence: 99%

Invasive or non-invasive imaging for detecting high-risk coronary lesions?

Patel

Tarkin

Serruys

et al. 2017

Expert Review of Cardiovascular Therapy

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Introduction: Advances in our understanding about atherosclerotic evolution have enabled us to identify specific plaque characteristics that are associated with coronary plaque vulnerability and cardiovascular events. With constant improvements in signal and image processing an arsenal of invasive and non-invasive imaging modalities have been developed that are capable of identifying these features allowing in vivo assessment of plaque vulnerability. Areas covered: This review article presents the available and emerging imaging modalities introduced to assess plaque morphology and biology, describes the evidence from the first large scale studies that evaluated the efficacy of invasive and non-invasive imaging in detecting lesions that are likely to progress and cause cardiovascular events and discusses the potential implications of the in vivo assessment of coronary artery pathology in the clinical setting. Expert commentary: Invasive imaging, with its high resolution, and in particular hybrid intravascular imaging appears as the ideal approach to study the mechanisms regulating atherosclerotic disease progression; whereas non-invasive imaging is expected to enable complete assessment of coronary tree pathology, detection of high-risk lesions, more accurate risk stratification and thus to allow a personalized treatment of vulnerable patients. ARTICLE HISTORY

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“…At first, GNP are administered by intravenous injection, and then are specifically phagocytized by tissue macrophages or by circulating monocytes/ macrophages that infiltrate tissues. Due to their physical properties, phagocytized GNP induce changes in the optical characteristics of infiltrated tissues that [52,53] OCT (Optical coherence tomography) [54] Non-invasive MRI (magnetic resonance imaging) [55,56] CT (computed X-ray tomography) [57] Ultrasound…”

Section: Novel Approach For In Vivo Imaging Of As Plaquesmentioning

confidence: 99%

Nanoparticle uptake by macrophages in vulnerable plaques for atherosclerosis diagnosis

Melzer

Ankri

Fixler

et al. 2015

Journal of Biophotonics

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The composition of atherosclerotic (AS) plaques is crucial concerning rupture, thrombosis and clinical events. Two plaque types are distinguished: stable and vulnerable plaques. Vulnerable plaques are rich in inflammatory cells, mostly only M1 macrophages, and are highly susceptible to rupture. These plaques represent a high risk particularly with the standard invasive diagnosis by coronary angiography. So far there are no non‐invasive low‐risk clinical approaches available to detect and distinguish AS plaque types in vivo. The perspective review introduces a whole work‐flow for a novel approach for non‐invasive detection and classification of AS plaques using the diffusion reflection method with gold nanoparticle loaded macrophages in combination with flow and image cytometric analysis for quality assurance. Classical biophotonic methods for AS diagnosis are summarized. Phenotyping of monocytes and macrophages are discussed for specific subset labelling by nanomaterials, as well as existing studies and first experimental proofs of concept for the novel approach are shown.

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In vivo detection of high-risk coronary plaques by radiofrequency intravascular ultrasound and cardiovascular outcome: results of the ATHEROREMO-IVUS study

Cited by 324 publications

References 24 publications

Invasive or non-invasive imaging for detecting high-risk coronary lesions?

Nanoparticle uptake by macrophages in vulnerable plaques for atherosclerosis diagnosis

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