2016
DOI: 10.1016/j.ahj.2016.09.003
|View full text |Cite
|
Sign up to set email alerts
|

Rationale and design of the Progression of AtheRosclerotic PlAque DetermIned by Computed TomoGraphic Angiography IMaging (PARADIGM) registry: A comprehensive exploration of plaque progression and its impact on clinical outcomes from a multicenter serial coronary computed tomographic angiography study

Abstract: BACKGROUND:The natural history of coronary artery disease (CAD) in patients with

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1
1
1

Citation Types

0
42
0

Year Published

2018
2018
2024
2024

Publication Types

Select...
8
1

Relationship

8
1

Authors

Journals

citations
Cited by 77 publications
(42 citation statements)
references
References 57 publications
(62 reference statements)
0
42
0
Order By: Relevance
“…The Progression of AtheRosclerotic PlAque DetermIned by Computed TomoGraphic Angiography Imaging (PARADIGM) study is a dynamic multinational observational registry that prospectively collected clinical, procedural, and follow-up data on patients who underwent clinically indicated serial CCTAs at an inter-scan interval of > _2 years between 2003 and 2015. 14 Clinical and laboratory results were collected within 1 month from both baseline and follow-up CCTA scans and clinical outcomes were followed. Hyperlipidaemia was defined using clinical guidelines at the time of enrolment of each patient.…”
Section: Study Design and Populationmentioning
confidence: 99%
“…The Progression of AtheRosclerotic PlAque DetermIned by Computed TomoGraphic Angiography Imaging (PARADIGM) study is a dynamic multinational observational registry that prospectively collected clinical, procedural, and follow-up data on patients who underwent clinically indicated serial CCTAs at an inter-scan interval of > _2 years between 2003 and 2015. 14 Clinical and laboratory results were collected within 1 month from both baseline and follow-up CCTA scans and clinical outcomes were followed. Hyperlipidaemia was defined using clinical guidelines at the time of enrolment of each patient.…”
Section: Study Design and Populationmentioning
confidence: 99%
“…The overall study design of the Progression of AtheRosclerotic PlAque DetermIned by Computed TomoGraphic Angiography IMaging (PARADIGM) registry has been previously described. 8 Briefly, the PARADIGM is a prospective, open-label, international, multicentre dynamic observational registry designed to evaluate associations between changes in serial CCTA imaging findings and clinical presentation. Between 2003 and 2015, a total of 2252 consecutive subjects underwent CCTA at 13 centres in seven countries (Supplementary data online, Table S1).…”
Section: Design Overview Setting and Participantsmentioning
confidence: 99%
“…Although currently it is not possible to recommend serial scans to monitor the therapeutic efficacy of a medical interventions, the plaque modulation, as a part of risk modification, is a feasible strategy. Direct visualization of the natural course of atherosclerosis, as well as identification of the clinical determinants of plaque progression or regression, holds the potential to shift the paradigm of CAD monitoring among low- to moderate-risk patients with suspected CAD, with aims of offering earlier therapeutic strategies [ 127 ]. It is reasonable to accept that a substantial reduction in plaque vulnerability by therapeutic intervention should contribute into plaque stability and in turn decrease cardiovascular event rates.…”
Section: Therapeutic Perspectivesmentioning
confidence: 99%