In vivo corrosion of four magnesium alloys and the associated bone response

Witte, Frank; Kaese, V.; Haferkamp, H.; Switzer, Elinor; Meyer‐Lindenberg, Andrea; Wirth, Carl Joachim; Windhagen, Henning

doi:10.1016/j.biomaterials.2004.09.049

Cited by 2,202 publications

(1,598 citation statements)

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“…Furthermore, degradation and biomineralization of bioactive materials on the surface on the magnesium scaffolds promote osteoblastic activity and ingrowth of the new tissue [35,45].…”

Section: Accepted M Manuscriptmentioning

confidence: 99%

“…The main challenge for employing Mg and its alloys as an implant is its high corrosion rate resulting in the rapid release of degradation products in the body [35,36]. The low corrosion resistance in physiological environments can have an adverse effect on the mechanical stability of the implant prior to bone healing [37].…”

mentioning

confidence: 99%

“…In contrast to inert materials such as PLA, the increase in bone formation and decrease in healing time observed with magnesium implants indicates the potential osteoconductivity and bioactivity of magnesium [29,35]. The Osteoconductivity of magnesium is induced by the precipitation of calcium phosphate on the surface of the implants in an in vitro environment due to corrosion [86,87].…”

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confidence: 99%

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Porous magnesium-based scaffolds for tissue engineering

Yazdimamaghani

Razavi

Vashaee

et al. 2017

Materials Science and Engineering: C

234

115

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“…Furthermore, degradation and biomineralization of bioactive materials on the surface on the magnesium scaffolds promote osteoblastic activity and ingrowth of the new tissue [35,45].…”

Section: Accepted M Manuscriptmentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

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Porous magnesium-based scaffolds for tissue engineering

Yazdimamaghani

Razavi

Vashaee

et al. 2017

Materials Science and Engineering: C

234

115

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“…As a consequence of its degradability, the second surgery for implant removal can be avoided. Furthermore, Mg has similar density and mechanical properties compared to cortical bone, and has non-toxic and biocompatible properties as well (Kirkland et al, 2010;Staiger et al, 2006;Witte et al, 2005). Complete bioresorption of Mg implants in vivo has been proven depending on the Mg-based material, keeping sufficient mechanical integrity during osteogenesis (Kraus et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

In vivo and in vitro degradation comparison of pure Mg, Mg-10Gd and Mg-2Ag: a short term study

Marco

Myrissa²,

Martinelli³

et al. 2017

eCM

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The purpose of this study was to compare short term in vitro and in vivo biodegradation studies with low purity Mg (> 99.94 %), Mg-10Gd and Mg-2Ag designed for biodegradable implant applications. Three in vitro testing conditions were applied, using (i) phosphate buffered saline (PBS), (ii) Hank's balanced salt solution (HBSS) and (iii) Dulbecco's modified eagle medium (DMEM) in 5 % CO 2 under sterile conditions. Gas evolution and mass loss (ML) were assessed, as well as the degradation layer, by elemental mapping and scanning electron microscopy (SEM). In vivo, implantations were performed on male Sprague-Dawley rats evaluating both, gas cavity volume and implant volume reduction by micro-computed tomography (µCT), 7 d after implantation. Samples were produced by casting, solution heat treatment and extrusion in disc and pin shape for the in vitro and in vivo experiments, respectively. Results showed that when the processing of the Mg sample varied, differences were found not only in the alloy impurity content and the grain size, but also in the corrosion behaviour. An increase of Fe and Ni or a large grain size seemed to play a major role in the degradation process, while the influence of alloying elements, such as Gd and Ag, played a secondary role. Results also indicated that cell culture conditions induced degradation rates and degradation layer elemental composition comparable to in vivo conditions. These in vitro and in vivo degradation layers consisted of Mg hydroxide, Mg-Ca carbonate and Ca phosphate.

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“…[56,67,[70][71] They have shown that RE can be detected in the corrosion layers and that percentage increased with the implantation time. Krause et al, [56] found 58% M a n u s c r i p t increase of the RE content in the outer layer of the implant surfaces between the 3 rd and 6 th month after implantation.…”

Section: Discussionmentioning

confidence: 99%