Porous magnesium-based scaffolds for tissue engineering

Yazdimamaghani, Mostafa; Razavi, Mehdi; Vashaee, Daryoosh; Moharamzadeh, Keyvan; Boccaccını, Aldo R.; Tayebi, Lobat

doi:10.1016/j.msec.2016.11.027

Cited by 234 publications

(135 citation statements)

References 114 publications

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“…Highly porous materials corrode very rapidly, as a larger area of the material surface is exposed to the corrosion environment. Corrosion resistance of either pure magnesium or magnesium alloys is seldom suitable for technical applications or even biomedical applications [3,9,[16][17][18][19][20]. Magnesium corrosion resistance can be improved by alloying the metal with aluminum, zinc or rare earth metal elements; however, for significantly better corrosion resistance, another way of reducing the degradation rate must be considered.…”

Section: Introductionmentioning

confidence: 99%

Characterization of Powder Metallurgy Processed Pure Magnesium Materials for Biomedical Applications

Zapletal

Březina

Krystýnová

et al. 2017

Metals

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Magnesium with its mechanical properties and nontoxicity is predetermined as a material for biomedical applications; however, its high reactivity is a limiting factor for its usage. Powder metallurgy is one of the promising methods for the enhancement of material mechanical properties and, due to the introduced plastic deformation, can also have a positive influence on corrosion resistance. Pure magnesium samples were prepared via powder metallurgy. Compacting pressures from 100 MPa to 500 MPa were used for samples' preparation at room temperature and elevated temperatures. The microstructure of the obtained compacts was analyzed in terms of microscopy. The three-point bending test and microhardness testing were adopted to define the compacts' mechanical properties, discussing the results with respect to fractographic analysis. Electrochemical corrosion properties analyzed with electrochemical impedance spectroscopy carried out in HBSS (Hank's Balanced Salt Solution) and enriched HBSS were correlated with the metallographic analysis of the corrosion process. Cold compacted materials were very brittle with low strength (up to 50 MPa) and microhardness (up to 50 HV (load: 0.025 kg)) and degraded rapidly in both solutions. Hot pressed materials yielded much higher strength (up to 250 MPa) and microhardness (up to 65 HV (load: 0.025 kg)), and the electrochemical characteristics were significantly better when compared to the cold compacted samples. Temperatures of 300 • C and 400 • C and high compacting pressures from 300 MPa to 500 MPa had a positive influence on material bonding, mechanical and electrochemical properties. A compacting temperature of 500 • C had a detrimental effect on material compaction when using pressure above 200 MPa.

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Section: Introductionmentioning

confidence: 99%

Characterization of Powder Metallurgy Processed Pure Magnesium Materials for Biomedical Applications

Zapletal

Březina

Krystýnová

et al. 2017

Metals

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“…It was shown that striking a balance between mechanical strength and porosity is one of the main problems in designing porous magnesium materials. [68] For biomedical applications, it seems that a good way is to somehow design the architecture of a porosity, for example, by the mapping of the titanium wire space holder. However, the pore walls obtained are rather smooth and this does not guarantee cell adhesion.…”

Section: Discussionmentioning

confidence: 99%

“…To simulate only the degradation, a simplified sample could be used, for example, a block with drilled holes [66] or laser perforated. [67] The mechanism of magnesium corrosion as proposed in recent studies is based on redox reactions (11)(12)(13) [68,69] …”

Section: Corrosionmentioning

confidence: 99%

“…Such a coating would inhibit further corrosion and increases in pH value, it could also promote osteoblast growth. [68] Another coating that is osteoconductive and inhibits the progress of corrosion is made of hydroxyapatite (HA), [52] a natural component of bone. There were concerns about altering the mechanical properties of the material, but studies have shown that hydroxyapatite-coated porous magnesium has similar properties to uncoated porous magnesium.…”

Section: Corrosionmentioning

confidence: 99%

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Current Status and Recent Developments in Porous Magnesium Fabrication

et al. 2017

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A significant number of studies have been dedicated to the fabrication and properties of metallic foams. The most recent research is focused on metals with low weight and good mechanical properties, such as titanium, aluminum, and magnesium. Whereas the first two are already fairly well studied and already find application in industry, magnesium currently remains at the research stage. The present review covers the studies conducted on fabrication techniques, surface modifications, and properties of porous structures made of magnesium and its alloys.

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“…One of the most guaranteed ways to ensure that the design of the scaffold will fit the needs and anatomical design of the affected area is to use clinical imaging data that will define the shape of the anatomical structure in combination with a global and local image database that consists of many different templates for the scaffold design [62,63]. Within the database is different structures for each porous scaffold design, varying from the nanometer to the centimeter scale [64,65]. The patient-specific images are taken from either a CT or MR image of the individual and the local image design is then determined.…”

Section: Scaffoldsmentioning

confidence: 99%

Cartilage and facial muscle tissue engineering and regeneration: a mini review

et al. 2018

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Cartilage and facial muscle tissue provide basic yet vital functions for homeostasis throughout the body, making human survival and function highly dependent upon these somatic components. When cartilage and facial muscle tissues are harmed or completely destroyed due to disease, trauma, or any other degenerative process, homeostasis and basic body functions consequently become negatively affected. Although most cartilage and cells can regenerate themselves after any form of the aforementioned degenerative disease or trauma, the highly specific characteristics of facial muscles and the specific structures of the cells and tissues required for the proper function cannot be exactly replicated by the body itself. Thus, some form of cartilage and bone tissue engineering is necessary for proper regeneration and function. The use of progenitor cells for this purpose would be very beneficial due to their highly adaptable capabilities, as well as their ability to utilize a high diffusion rate, making them ideal for the specific nature and functions of cartilage and facial muscle tissue. Going along with this, once the progenitor cells are obtained, applying them to a scaffold within the oral cavity in the affected location allows them to adapt to the environment and create cartilage or facial muscle tissue that is specific to the form and function of the area. The principal function of the cartilage and tissue is vascularization, which requires a specific form that allows them to aid the proper flow of bodily functions related to the oral cavity such as oxygen flow and removal of waste. Facial muscle is also very thin, making its reproduction much more possible. Taking all these into consideration, this review aims to highlight and expand upon the primary benefits of the cartilage and facial muscle tissue engineering and regeneration, focusing on how these processes are performed outside of and within the body.

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Porous magnesium-based scaffolds for tissue engineering

Cited by 234 publications

References 114 publications

Characterization of Powder Metallurgy Processed Pure Magnesium Materials for Biomedical Applications

Characterization of Powder Metallurgy Processed Pure Magnesium Materials for Biomedical Applications

Current Status and Recent Developments in Porous Magnesium Fabrication

Cartilage and facial muscle tissue engineering and regeneration: a mini review

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