In�vivo confocal laser scanning microscopy imaging of skin inflammation: Clinical applications and research directions (Review)

Ilie, Mihaela; Căruntu, Constantin; Lixandru, Daniela; Tampa, Mircea; Georgescu, Simona Roxana; Constantin, Maria‐Magdalena; Constantin, Carolina; Neagu, Monica; Zurac, Sabina; Boda, Daniel

doi:10.3892/etm.2018.6981

Cited by 45 publications

(41 citation statements)

References 51 publications

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“…Skin ageing can be due to natural processes occurred, intensified or accumulated in time (chronological, intrinsic or natural ageing) or upon solar radiation exposure (extrinsic, photo-ageing). Changes in the dermal layer of the skin, alteration and modifications of the extracellular matrix, as well as increased inflammatory markers and decreased blood flow lead to aging skin (18)(19)(20).…”

Section: Skin Ageing -Natural Occurrence and External Triggersmentioning

confidence: 99%

Beneficial effects of food supplements based on hydrolyzed collagen for skin care (Review)

Lupu¹,

Pîrcălăbioru²,

Chifiriuc

et al. 2019

Exp Ther Med

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Ageing is a complex, multi-step process which involves, among others loss of collagen and elastin. Collagen is found in large amounts in the body, especially in the dermis layer. These fibers provide the skin's normal strength, hydration and mechanical properties. Collagen is largely available, as it can be extracted from many animal sources, it can be easily absorbed upon topical administration, hence it is largely used in the cosmetic and pharmaceutical industry for the treatment of premature aging. Bioactive peptides, such as collagen hydrolyzate, are among the most used ingredients for the development of nutraceuticals-food or food ingredients that have defined physiological effects. Numerous studies have demonstrated that peptides resulted from ingestion of hydrolysate collagen and detected in the blood stream have chemotactic properties for skin fibroblasts, helping the skin restoration process. The purpose of this minireview is to present an update on the use of hydrolyzed collagen for skin care. Contents 1. Introduction 2. Skin ageing-natural occurrence and external triggers33. 3. Sources of collagen peptides 4. Clinical evidence for the beneficial roles of collagen based products for skin care 5. Conclusions

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Section: Skin Ageing -Natural Occurrence and External Triggersmentioning

confidence: 99%

Beneficial effects of food supplements based on hydrolyzed collagen for skin care (Review)

Lupu¹,

Pîrcălăbioru²,

Chifiriuc

et al. 2019

Exp Ther Med

View full text Add to dashboard Cite

show abstract

“…It has been observed that microvascular endothelial dysfunction has as substrate the appearance of anti-endothelial antibodies and, mainly, the presence of anti-intercellular adhesion molecule (ICAM)-1 antibodies (6). Activated endothelial cells release proinflammatory cytokines and connective tissue growth factors, interleukin (IL)-1, IL-4, tumor necrosis factor (TNF)-α, IL-6 and IL-8 transforming growth factor (TGF)-β, which induce aberrant hyperactivated fibroblasts (7)(8)(9)(10)(11). Early endothelial cell involvement in SSc, leads to the destruction of blood capillaries with reduction in microvasculature through vascular repair and defective neoangiogenesis simultaneously with impaired lymphatic circulation followed by exudative accumulation and edema formation.…”

Section: Introductionmentioning

confidence: 99%

Dynamics of digital ulcers in systemic sclerosis

et al. 2020

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Systemic sclerosis (SSc) is a collagenosis with insufficiently known etiopathogenesis, characterized by microvasculopathy and excessive fibrosis in the context of an autoimmune disorder. The incompletely elucidated pathogenesis and limited therapeutic options, disabling aspects, skin lesions and pain determine important functional and psychological deficiencies which affect the quality of life. It is imperative to observe and correlate individual clinical and paraclinical data to optimize disease management. A group of 22 patients diagnosed with SSc, hospitalized in a university clinic in Bucharest was included in an observational study. The evolution of digital ulcers was evaluated as an indicator of vasculopathy and their status and dynamics were correlated with clinical elements reflecting the fibrotic aspect of the disease. The present study shows that the Raynaud phenomenon is almost always present during the course of the disease, but its presence is not always associated with digital ulcers. The existing data in the literature show that fibrosis is subsequent to vasculopathy, but this study did not reveal causality between these two aspects of pathogenesis. The presence of microstomia and digital contracture was identified in the presence of digital ulcers, but also in their absence. The etiopathogenic mechanisms with multiple unknown involved factors open the opportunity to investigate many aspects of SSc for optimal aiming of therapeutic interventions.

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“…Imaging techniques are also used to assess non-invasive skin changes in psoriasis or high performance liquid chromatography or cell membrane fluidity; however, this study aimed to evaluate only the inflammatory activity (24)(25)(26)(27).…”

Section: Discussionmentioning

confidence: 99%

Inflammatory marker alteration in response to systemic therapies in psoriasis

et al. 2020

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Substantial research has focused on the presence of biomarkers involved in both the pathogenesis of psoriasis and its comorbidities. The identification of these biomarkers has a crucial role in establishing the diagnosis and prognosis, in understanding the physiopathological mechanism and in determining the therapeutic response. The aim of this study was to emphasize the alteration in inflammatory markers in response to systemic therapies in psoriasis. Evolution of inflammatory marker alteration was studied in 194 patients with psoriasis, aged between 7 and 87 years. Two groups were set up: the first comprised of patients treated with methotrexate (n=51), while the second comprised patients treated with biological therapy (n=143). Each group was evaluated for blood values of C-reactive protein (CRP), erythrocyte sedimentation rate (ESR) and fibrinogen before and after treatment, the fluctuation of these values according to the treatment, the interrelation between inflammatory markers and inflammatory activity of the disease and the evolution of the disease after treatment. In group I, 46 out of 51 patients had elevated levels of acute phase reactants before treatment. After treatment with methotrexate 7.5 mg/week, 12 out of 46 patients had elevated blood levels of ESR and 18 out of 46 patients of CRP and fibrinogen. Before treatment with biological therapy, 138 patients out of 143 presented abnormal high range for acute phase reactants. After treatment with biological therapy, 18 patients out of 138 had elevated blood levels of ESR and 37 patients out of 138 had elevated CRP and fibrinogen. A favorable evolution was noted in 98 patients out of 138. It was concluded that the systemic treatment with both methotrexate and biological therapy showed a marked decline in the patients with abnormal values of CRP, ESR and fibrinogen, indirectly showing a decline in the inflammatory activity of psoriasis.

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In�vivo confocal laser scanning microscopy imaging of skin inflammation: Clinical applications and research directions (Review)

Cited by 45 publications

References 51 publications

Beneficial effects of food supplements based on hydrolyzed collagen for skin care (Review)

Beneficial effects of food supplements based on hydrolyzed collagen for skin care (Review)

Dynamics of digital ulcers in systemic sclerosis

Inflammatory marker alteration in response to systemic therapies in psoriasis

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