In Vivo Confirmation of the Role of Statins in Reducing Nitric Oxide and C-Reactive Protein Levels in Peripheral Arterial Disease

Aguilar, Esther Martínez; Haro, Joaquín De; González, A. Flórez; Casariego, C. Varela; Moreno, Silvia Bleda; García, Francisco Acín

doi:10.1016/j.ejvs.2008.12.009

Cited by 13 publications

(7 citation statements)

References 34 publications

(30 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Additionally, nearly all of the patients with dyslipidemia were being treated with statin medication, which may have improved their ambulation, inflammation, and oxidative stress measures. 27–29 Finally, there are limitations associated with the design of the study. The correlations calculated between the clinical measures and the vascular biomarkers from this cross-sectional design do not allow causality to be established.…”

Section: Discussionmentioning

confidence: 99%

Monitored Daily Ambulatory Activity, Inflammation, and Oxidative Stress in Patients With Claudication

et al. 2013

View full text Add to dashboard Cite

We determined the association between daily ambulatory activity and markers of inflammation and oxidative stress in patients with peripheral artery disease (PAD) and claudication. Patients with PAD (n=134) limited by claudication were studied. Patients took 3275±1743 daily strides during 273±112 min each day, and their average daily cadence was 11.7±2.7 strides/min. High-sensitivity C-reactive protein was significantly and negatively associated with the total number of daily strides (p<0.001), total daily ambulatory time (p<0.01), peak activity index (p<0.01), daily average cadence (p<0.05), and the maximum cadences for 60 min (p<0.05), 30 min (p<0.05), 20 min (p<0.05) and 5 min (p<0.01). Oxidized low density lipoprotein and soluble vascular cell adhesion molecule-1 were not significantly associated with any of the ambulatory measures (p>0.05). We conclude that higher levels of community-based, daily ambulatory activity are associated with lower levels of inflammation, but are not associated with markers of oxidative stress.

show abstract

Section: Discussionmentioning

confidence: 99%

Monitored Daily Ambulatory Activity, Inflammation, and Oxidative Stress in Patients With Claudication

et al. 2013

View full text Add to dashboard Cite

show abstract

“…Recent data show that statins may reduce oxidative stress [ 47 ] by decreasing the generation of ROS, thereby synergizing with the biological effects of antioxidants [ 48 ]. The results of our study show that ceruloplasmin activity was influenced by both simvastatin therapy and surgical treatment, but only 7–10 days postoperatively.…”

Section: Discussionmentioning

confidence: 99%

Effect of Surgical Treatment on Lipid Peroxidation Parameters and Antioxidant Status in the Serum of Patients with Peripheral Arterial Disease

et al. 2013

View full text Add to dashboard Cite

The various risk factors for peripheral arterial disease (PAD) are almost identical to those for atherosclerosis and include abnormal levels of lipids or lipoproteins. Lipid peroxidation parameters and total antioxidant capacity in the serum of male patients with PAD before surgery as well as 3–5 days and 7–10 days after surgery were measured. We also compared these parameters with those in a group of patients receiving simvastatin therapy. Concentrations of lipid hydroperoxides (LOOHs) and malondialdehyde, the total antioxidant capacity (assessed by ferric reducing antioxidant power assay), concentration of thiol (-SH) groups, and ceruloplasmin activity were determined spectrophotometrically in PAD patients treated surgically (Group I) or pharmacologically (Group II). The patients before surgical treatment had significantly higher concentrations of malondialdehyde but lower ceruloplasmin activity than those observed in Group II, treated with simvastatin. No significant differences before surgery in ferric reducing antioxidant power or thiol concentrations were found between the two groups. However, in Group I, both ferric reducing antioxidant power and thiol group concentrations decreased 3–5 days postoperatively, and ceruloplasmin activity increased 7–10 days after surgical treatment. The presented results demonstrate diverse oxidative stress responses to surgical treatment and confirm the beneficial effects of statin therapy in PAD.

show abstract

“…Additionally, statins prevent the oxidation of BH4 to BH3. The result of these processes is reduced oxidative stress in endothelial cells and improved eNOS function [43].…”

Section: Signaling Pathways and Molecules Mediating The Effect Of Stamentioning

confidence: 99%

“…A study which included 30 patients with peripheral arterial diseases showed that one-month of treatment with atorvastatin significantly reduced plasma ONOO− levels and reduced oxidative stress, resulting in reduced eNOS uncoupling and increased NO production [43]. Rasmusen et al also showed that atorvastatin combined with a NO precursor, arginine, exert anti-atherosclerotic actions via eNOS activation and NO production [82].…”

Section: Atherosclerosismentioning

confidence: 99%

Statin-Induced Nitric Oxide Signaling: Mechanisms and Therapeutic Implications

Gorabi

Kiaie

Hajighasemi

et al. 2019

JCM

View full text Add to dashboard Cite

In addition to their cholesterol-lowering effects, statins are associated with pleiotropic effects including improvements in heart failure (HF), reduced blood pressure, prevention of the rupture of atherosclerotic plaques and improved angiogenesis. In addition to these cardiovascular benefits, statins have been implicated in the treatment of neurological injuries, cancer, sepsis, and cirrhosis. These cholesterol-independent beneficial effects of statins are predominantly mediated through signaling pathways leading to increased production and bioavailability of nitric oxide (NO). In this review, the mechanistic pathways and therapeutic effects of statin-mediated elevations of NO are described and discussed.

show abstract

In Vivo Confirmation of the Role of Statins in Reducing Nitric Oxide and C-Reactive Protein Levels in Peripheral Arterial Disease

Cited by 13 publications

References 34 publications

Monitored Daily Ambulatory Activity, Inflammation, and Oxidative Stress in Patients With Claudication

Monitored Daily Ambulatory Activity, Inflammation, and Oxidative Stress in Patients With Claudication

Effect of Surgical Treatment on Lipid Peroxidation Parameters and Antioxidant Status in the Serum of Patients with Peripheral Arterial Disease

Statin-Induced Nitric Oxide Signaling: Mechanisms and Therapeutic Implications

Contact Info

Product

Resources

About