2014
DOI: 10.1007/s00586-014-3705-0
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In vivo compatibility of Dynesys® spinal implants: a case series of five retrieved periprosthetic tissue samples and corresponding implants

Abstract: This is the first study to evaluate wear accumulation and local tissue responses for explanted Dynesys(®) devices. Polymer wear debris and an associated foreign-body macrophage response were observed in three of five cases.

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Cited by 9 publications
(15 citation statements)
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“…However, retrieved PCU spinal spacers (0.7 to 7 years) exhibited permanent deformation and surface damage (Ianuzzi et al, 2010). PCU wear debris and an associated macrophage response were also observed in some retrivals affected by major failures (Neukamp et al, 2015).…”
Section: Introductionmentioning
confidence: 99%
“…However, retrieved PCU spinal spacers (0.7 to 7 years) exhibited permanent deformation and surface damage (Ianuzzi et al, 2010). PCU wear debris and an associated macrophage response were also observed in some retrivals affected by major failures (Neukamp et al, 2015).…”
Section: Introductionmentioning
confidence: 99%
“…Explanted orthopaedic implants, which contain PCU components, have demonstrated new absorbance peaks at 1650 cm −1 and/or 1174 cm −1 to demonstrate biological oxidative degradation . However, another explant study did not find new absorbance peaks linked to biological oxidative degradation .…”
Section: Discussionmentioning
confidence: 97%
“…In particular, the polyurethane (PU) group, and more specifically polycarbonate urethanes (PCU), are used in vascular catheters [6,7] and orthopaedic [8][9][10][11] applications. Though PCU has been shown to be more biostable than polyether urethanes (PEU) [12,13], another polymer in the PU group used in cardiovascular applications [14], PCU components of explanted orthopaedic implants have been reported to degrade in the human body due to oxidation [9,15]. This oxidative degradation results in the cleavage of chemical bonds in a polymer [16] and has been shown to adversely affect the surface chemical structure of the PCU spacer of the Dynesys spinal stabilisation device (Zimmer, Warsaw, Indiana, USA) [15,[17][18][19].…”
Section: Introductionmentioning
confidence: 99%
“…Though PCU has been shown to be more biostable than polyether urethanes (PEU) [12,13], another polymer in the PU group used in cardiovascular applications [14], PCU components of explanted orthopaedic implants have been reported to degrade in the human body due to oxidation [9,15]. This oxidative degradation results in the cleavage of chemical bonds in a polymer [16] and has been shown to adversely affect the surface chemical structure of the PCU spacer of the Dynesys spinal stabilisation device (Zimmer, Warsaw, Indiana, USA) [15,[17][18][19]. To replicate and understand the effect of in vivo oxidation on chemical structure, an accelerated in vitro oxidation method to degrade PCU biomaterials has been reported [8,12,20].…”
Section: Introductionmentioning
confidence: 99%
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